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50264-69-2

50264-69-2 Structure

50264-69-2 Structure
IdentificationMore
[Name]

Lonidamine
[CAS]

50264-69-2
[Synonyms]

1-[2,4-DICHLOROBENZYL]-1H-INDAZOLE-3-CARBOXYLIC ACID
1-[(2,4-DICHLOROPHENYL)METHYL]-1H-INDAZOLE-3-CARBOXYLIC ACID
DICLONDAZOLIC ACID
LONIDAMINE
1-((2,4-dichlorophenyl)methyl)-1h-indazole-3-carboxylicaci
1-(2,4-dichlorbenzyl)-indazole-3-carboxylicacid
1-(2,4-dichlorobenzyl)-1h-indazole-3-carboxylicaci
af1890
dica
doridamina
1-(2,4-Dichlorobenzyl)indazole-3-carboxylic acid
Lonidnmine
1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid, DICA
1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid, Diclondazolic acid
1-[(2,4-Dichloropheny1) methyl]-1H-indazole-3-carboxylic acid
13iclondazolic Acid
AF-1890:DICA
lonidamin
[EINECS(EC#)]

256-510-0
[Molecular Formula]

C15H10Cl2N2O2
[MDL Number]

MFCD00866285
[Molecular Weight]

321.16
[MOL File]

50264-69-2.mol
Chemical PropertiesBack Directory
[mp ]

207-209°C
[CAS DataBase Reference]

50264-69-2(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

R60:May impair fertility.
R22:Harmful if swallowed.
R40:Limited evidence of a carcinogenic effect.
[Safety Statements ]

S53:Avoid exposure-obtain special instruction before use .
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[WGK Germany ]

3
[RTECS ]

NK7886000
[HS Code ]

29339900
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Sodium nitrite-->Potassium iodide-->Stannous chloride dihydrate-->Isatin-->Indazole-3-carboxylic acid-->2,4-Dichlorobenzoyl chloride
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

1-(2,4-Dichlorobenzyl)-1H-indazole-3-carboxylic acid(50264-69-2).msds
Questions And AnswerBack Directory
[Description]

Lonidamine is a derivative of indazole-3-carboxylic acid. It is a kind of orally administrated small molecule, which can inhibit the glycolysis process through inactivating the hexokinase (the first step in glycolysis). It has been shown that cancer cell primarily generates energy through glycolysis process. Therefore, Lonidamine has been used for the treatment of several kinds of cancers. One special property of Lonidamine is that it seems to enhance aerobic glycolysis in normal cells, but inhibit glycolysis only in cancer cells. In addition, there are also evidences that Lonidamine may increase the occurrence of apoptosis. It has also been shown that Lonidamine is effective in the treatment of benigh prostatic hyperplasia (BPH).
[References]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1477623/
https://en.wikipedia.org/wiki/Lonidamine
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

50264-69-2(sigmaaldrich)
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