| Identification | More | [Name]
Cyanogen bromide | [CAS]
506-68-3 | [Synonyms]
BROMINE CYANIDE
BROMOCYAN
BROMOCYANE
BROMOCYANIDE
CYANOGEN BROMIDE
(CN)Br
BrCN
Bromine cyanide(BrCN)
Bromine monocyanide
brominecyanide(brcn)
Bromocyanide(BrCN)
Bromocyanogen
Bromure de cyanogen
bromuredecyanogen
bromuredecyanogen(french)
bromuredecyanogene
Campilit
Cyanic bromide
Cyanobromide
Cyanogen bromide ((CN)Br) | [EINECS(EC#)]
208-051-2 | [Molecular Formula]
CBrN | [MDL Number]
MFCD00011597 | [Molecular Weight]
105.92 | [MOL File]
506-68-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Cyanogen bromide is a colorless or white,
volatile, crystalline solid with a penetrating odor.
| [Melting point ]
50-53 °C(lit.)
| [Boiling point ]
61-62 °C(lit.)
| [density ]
1.443 g/mL at 25 °C
| [vapor density ]
3.65 (vs air)
| [vapor pressure ]
100 mm Hg ( 22.6 °C)
| [refractive index ]
1.4670 (estimate) | [Fp ]
61.4°C | [storage temp. ]
0-6°C
| [solubility ]
Soluble in chloroform, dichloromethane, ethanol, diethyl ether, benzene and acetonitrile. | [form ]
Solution | [color ]
White | [Odor]
Penetrating odor | [Stability:]
Stable. Reacts violently with water and with mineral and organic acids. | [Water Solubility ]
decomposed slowly by cold H2O [HAW93] | [Sensitive ]
Moisture & Light Sensitive | [Merck ]
14,2693 | [BRN ]
1697296 | [Exposure limits]
No exposure limit is set. However, on the basis of the exposure limits of related compounds a ceiling limit of 0.5 ppm (2 mg/m3) is recommended. | [CAS DataBase Reference]
506-68-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Cyanogen bromide(506-68-3) | [EPA Substance Registry System]
506-68-3(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
Cyanogen bromide is a colorless or white,
volatile, crystalline solid with a penetrating odor.
| [Chemical Properties]
white crystalline solid | [Uses]
Reaction with C60Ph5Cl produces a novel phenylated isoquinolino[3′,4′:1,2][60]fullerene.1 | [Uses]
Reagent for the synthesis of cyanamides. | [General Description]
CYANOGEN BROMIDE(506-68-3) is a colorless to white crystalline solid with a penetrating odor. CYANOGEN BROMIDE(506-68-3) is slightly soluble in water. CYANOGEN BROMIDE(506-68-3) is gradually decomposed by water and very rapidly by acids to give off hydrogen bromide, a flammable and poisonous gas. Contamination with many materials can cause rapid decomposition of the material. CYANOGEN BROMIDE(506-68-3) is toxic by inhalation of its vapors or by the hydrogen cyanide from decomposition or by ingestion. Toxic oxides of nitrogen are produced in fire involving this material. CYANOGEN BROMIDE(506-68-3) is used in gold extraction, to make other chemicals, and as a fumigant. | [Reactivity Profile]
CYANOGEN BROMIDE is not combustible itself, but impure cyanogen bromide decomposes rapidly and tends to explode. A violent reaction may take place on contact with large quantities of acid. Avoid physical damage, contact with acids or water, and store away from a location where water may be needed for fire control. [EPA, 1998]. Benzene and cyanogen halides yield HCl as a byproduct (Hagedorn, F. H. Gelbke, and Federal Republic of Germany. 2002. Nitriles. In Ullman Encyclopedia of Industrial Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA.). | [Air & Water Reactions]
CYANOGEN BROMIDE is slightly soluble in water. CYANOGEN BROMIDE is gradually decomposed by water and very rapidly by acids to give off hydrogen bromide, a poison gas. | [Health Hazard]
Exposure to cyanogen bromide is dangerous. The chemical substance is poisonous and
causes fatal injury if swallowed, inhaled, or absorbed through the skin. It is corrosive and the vapors cause severe irritation to the eyes and respiratory tract, and cause burns to any
area of contact. On contact with acids, cyanogen bromide liberates poisonous gas, affecting
the blood, cardiovascular system, CNS, and thyroid. | [Health Hazard]
Super toxic; probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lb.) person. Vapors are highly irritant and very poisonous. Individuals with chronic diseases of the kidneys, respiratory tract, skin, or thyroid are at greater risk of developing toxic cyanide effects. | [Potential Exposure]
Used as an activating reagent for
insoluble supports for affinity absorption. In danger are
those manufacturing this compound or using it in organic
synthesis or as a fumigant; in textile treatment; in gold
cyaniding. It may have been used as a military poison
gas. | [Fire Hazard]
Cyanogen bromide is not combustible itself, but impure cyanogen bromide decomposes rapidly and tends to explode. A violent reaction may take place on contact with large quantities of acid. Vapors are highly irritating. When material is heated to decomposition, CYANOGEN BROMIDE emits very toxic fumes of cyanide and bromide. Avoid water, acids. Avoid physical damage, contact with acids or water, and store away from a location where water may be needed for fire control. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
Medical attention immediately. If this chemical contacts
the skin, remove contaminated clothing and wash immedi-
ately with soap and water. Seek medical attention immedi-
ately. Do not perform direct mouth to mouth resuscitation;
use bag/mask apparatus. If this chemical has been inhaled,
remove from exposure, begin rescue breathing (using uni-
versal precautions, including resuscitation mask) if breath-
ing has stopped and CPR if heart action has stopped.
Transfer promptly to a medical facility. When this chemical
has been swallowed, get medical attention. If victim is con-
scious, administer water or milk. Do not induce vomiting.
Medical observation is recommended for 24 to 48 hours
after breathing overexposure, as pulmonary edema may be
delayed. As first aid for pulmonary edema, a doctor or
authorized paramedic may consider administering a drug or
other inhalation therapy.br Use amyl nitrate capsules if symptoms of cyanide poison-
ing develop. All area employees should be trained regularly
in emergency measures for cyanide poisoning and in CPR.
A cyanide antidote kit should be kept in the immediate
work area and must be rapidly available. Kit ingredients
should be replaced every 1 2 years to ensure freshness.
Persons trained in the use of this kit; oxygen use, and CPR
must be quickly available. | [Shipping]
UN1889 Cyanogen bromide, Hazard class: 6.1;
Labels: 6.1-Poisonous materials, 8-Corrosive material. A
DOT regulated marine pollutant. | [Incompatibilities]
May be unstable unless dry and pure;
impure cyanogen bromide decomposes rapidly and tends to
explode. Cyanogen bromide decomposes violently on heat-
ing or on contact with water, acids, or acid vapors; produc-
ing highly toxic and flammable hydrogen cyanide and
corrosive hydrogen bromide. Avoid physical damage, con-
tact with acids or water, and store away from a location
where water may be needed for fire control
. Violent
reaction with ammonia, amines. | [Description]
Cyanogen Bromide is a colorless or white,volatile, crystalline solid with a penetrating odor. Molecularweight=105.93; Boiling point=61-62℃; Freezing/Melting point=52℃. Hazard Identification (based onNFPA-704 M Rating System): Health 3, Flammability 0,Reactivity 3 . Soluble in water; dangerous reaction. | [Waste Disposal]
May be added to strong alka-
line solution of calcium hypochlorite, let stand for 24 hours
and flush to sewer. May also be dissolved in flammable
solvent and sprayed into an incinerator equipped with after-
burner and scrubber. | [Production Methods]
Cyanogen bromide may be prepared by either the action of
bromine on potassium cyanide or the interaction of sodium
bromide, sodium cyanide, sodium chlorate, and sulfuric
acid. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 68, p. 2102, 1946 DOI: 10.1021/ja01214a501 | [Purification Methods]
All operations with this substance should be performed in a very efficient fume cupboard-it is very POISONOUS and should be handled in small amounts. Fresh commercial material is satisfactory for nearly all purposes and does not need to be purified. It is a white crystalline solid with a strong cyanide odour. If it is reddish in colour and partly liquid or paste-like, then it is too far gone to be purified, and fresh material should be sought. It can be purified by distillation using small amounts at a time, and using a short wide-bore condenser because it readily solidifies to a crystalline white solid which may clog the condenser. An appropriate gas mask should be used when transferring the molten solid from one container to another, and the operation should be done in an efficient fume cupboard. The melting point (m 49-51o) should be measured in a sealed tube. [Hartman & Dreger Org Synth Coll Vol II 150 1948.] | [Flammability and Explosibility]
Cyanogen bromide is noncombustible. Impure material decomposes rapidly and can be explosive. | [storage]
work with BrCN should be conducted in a fume hood to prevent exposure by inhalation, and splash goggles and impermeable gloves should be worn at all times to prevent eye and skin contact. Containers of cyanogen bromide should be kept tightly sealed and stored under nitrogen in a secondary container in a refrigerator. |
| Safety Data | Back Directory | [Hazard Codes ]
T+,N,F,C | [Risk Statements ]
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed .
R34:Causes burns.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R40:Limited evidence of a carcinogenic effect.
R11:Highly Flammable.
R36/37:Irritating to eyes and respiratory system . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S16:Keep away from sources of ignition-No smoking .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 3390 6.1/PG 1
| [WGK Germany ]
3
| [RTECS ]
GT2100000
| [F ]
8-17-19-21 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
I | [HS Code ]
28530090 | [Safety Profile]
A human and
experimental poison by inhalation.
Corrosive. When heated to decomposition it
emits very toxic fumes of CNand Br-.
Possibly unstable. See also other cyanogen
entries; CYANIDE; and BROMIDES. | [Hazardous Substances Data]
506-68-3(Hazardous Substances Data) | [Toxicity]
LCLO inhal (human) 92 ppm (398 mg/m3; 10 min)
LCLO inhal (mouse) 115 ppm (500 mg/m3; 10 min) |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Sodium bromide | [Preparation Products]
4-METHOXY-2-MORPHOLIN-4-YL-THIAZOLE-5-CARBALDEHYDE-->Fluoxetine-->Admire-->((1R,4S)-2-Azabicyclo[2.2.1]hept-5-en-3-one-->2-Bromofuran-->MORPHOLINE-4-CARBOTHIOAMIDE-->2-(4-difluoromethoxy)phenyl-3-methyl butyric acid-->Diethyl cyanophosphonate-->1,1,1,3,3,3-Hexafluoro-2-propanol-->3-bromo-2-chloroprop-1-ene-->DIETHYLCYANAMIDE-->1-Bromopentane-->2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline-->1-PIPERIDINECARBONITRILE-->2,4,6-trip-tolyl-1,3,5-triazine-->4-CHLORO-3-NITROBENZAMIDE-->Ethyl 5,6-dichloro-3,4-dihydro-2(1H)-iminoquinazoline-3-acetate hydrobromide |
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