| Identification | More | [Name]
4'-PIPERAZINOACETOPHENONE | [CAS]
51639-48-6 | [Synonyms]
1-(4-ACETYLPHENYL)PIPERAZINE
1-(4-PIPERAZIN-1-YL-PHENYL)ETHANONE
4'-(PIPERAZIN-4-YL)ACETOPHENONE
4-PIPERAZINEACETOPHENONE
4'-PIPERAZINOACETOPHENONE
4-PIPERAZINOACETOPHENONE
BUTTPARK 62\14-24
LABOTEST-BB LT00138218
piperazin-4-ylacetophenone
4’-(1-Piperazino)acetophenone
4'-(1-piperazino)acetophenone, tech.
1-(4-Acetylphenyl)piperazine 96%
4-PIPERAZINEOACETOPHENONE
p-(1-Piperazinyl)acetophenone
p-Piperazinoacetophenone | [EINECS(EC#)]
257-332-6 | [Molecular Formula]
C12H16N2O | [MDL Number]
MFCD00005962 | [Molecular Weight]
204.27 | [MOL File]
51639-48-6.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow powder or chunks | [Melting point ]
107-110 °C(lit.) | [Boiling point ]
342.77°C (rough estimate) | [density ]
1.0565 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
2-8°C | [solubility ]
Benzene (Slightly, Heated), Chloroform (Slightly), DMSO (Slightly, Heated) | [form ]
Powder or Chunks | [pka]
8.80±0.10(Predicted) | [color ]
Yellow | [CAS DataBase Reference]
51639-48-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
3259 | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
8 | [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow powder or chunks | [Uses]
1-[4-(1-Piperazinyl)phenyl]ethanone is a useful building block for organic synthesis. | [Synthesis]
1. Potassium carbonate (2.99 g, 21.6 mmol) was placed in a round-bottomed flask and dried under vacuum with a hot air gun.
2. Tetrabutylammonium bromide (0.045 g, 0.14 mmol) and piperazine (1.54 g, 17.9 mmol) dissolved in anhydrous dimethyl sulfoxide (5 mL) were added sequentially.
3. The reaction mixture was stirred at 80 °C, followed by the addition of 4-fluoroacetophenone (2 g, 14.4 mmol) and the reaction was refluxed for 15 h at the same temperature.
4. After completion of the reaction, the mixture was cooled to room temperature, diluted with water and the solid was collected by filtration.
5. The filtrate was acidified with dilute hydrochloric acid and subsequently extracted with ethyl acetate.
6. The aqueous layer was alkalized with sodium hydroxide and extracted with chloroform.
7. The chloroform layers were combined, dried over anhydrous sodium sulfate and concentrated to give the light yellow solid product 4'-piperazineacetophenone (2.23 g, 75.25% yield, melting point 109°C). 8. The product was analyzed by 1H NMR.
8. The product was characterized by 1H NMR (200 MHz, CDCl3): δ 1.91 (s, 1H), 2.52 (s, 3H), 2.98-3.05 (m, 4H), 3.28-3.35 (m, 4H), 6.87 (d, J = 8.8 Hz, 2H), 7.87 (d, J = 8.8 Hz, 2H). | [References]
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5507 - 5520
[2] Patent: WO2014/132267, 2014, A1. Location in patent: Page/Page column 33
[3] Patent: WO2005/7637, 2005, A1. Location in patent: Page 7-8 |
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