| Identification | More | [Name]
2-Oxo-(2H)-furo(2,3-h)-1-benzopyran | [CAS]
523-50-2 | [Synonyms]
2-OXO-[2H]-FURO[2,3-H]-1-BENZOPYRAN
ANGELICIN
ANGELICINE
ISOBERGAPTEN
ISOPSORALEN
ISOPSORALENE
2h-furo(2,3-h)(1)benzopyran-2-one
2h-furo(2,3-h)-1-benzopyran-2-one
3-(4-hydroxy-5-benzofuranyl)-2-propenoicacidelta-lactone
3-(4-hydroxy-5-benzofuranyl)-2-propenoicacidgamma-lactone
4-hydroxy-5-benzofuranacrylicacidgamma-lactone
angecin
angelicin(coumarinderiv)
furo(2,3-h)coumarin
furo(5’,4’,7,8)coumarin
furo(5’,4’:7,8)coumarin
isopsoralin
Isopsoralen （Angelicin）
FURO(2,3-H)BENZOPYRAN-2-ONE
ANGELICINE hplc | [EINECS(EC#)]
637-055-0 | [Molecular Formula]
C11H6O3 | [MDL Number]
MFCD00064930 | [Molecular Weight]
186.16 | [MOL File]
523-50-2.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
132-134°C | [Boiling point ]
104°C/4mmHg(lit.) | [density ]
1.2477 (rough estimate) | [refractive index ]
1.6310 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
neat | [color ]
White | [Usage]
Antifungal | [λmax]
302nm(EtOH)(lit.) | [BRN ]
153970 | [InChI]
InChI=1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H | [InChIKey]
XDROKJSWHURZGO-UHFFFAOYSA-N | [SMILES]
C1(=O)OC2C3C=COC=3C=CC=2C=C1 | [LogP]
2.080 | [CAS DataBase Reference]
523-50-2(CAS DataBase Reference) | [IARC]
3 (Vol. 40, Sup 7) 1987 | [NIST Chemistry Reference]
2H-furo[2,3-h]-1-benzopyran-2-one(523-50-2) |
| Questions And Answer | Back Directory | [Synthesis]
Iodination of commercially available umbelliferone (7-hydroxycoumarin) yields 7-hydroxy-8-iodocoumarin. Acetoxy group can be introduced into hydroxyl of 7-hydroxy-8-iodocoumarin, which is used to create vaginol or vaginidiol with an isopropyl Grignard reagent and commercially available epoxy aldehydes. Subsequent acid-catalysed fragmentation of vaginol with dichloromethane in trifluoroacetic acid yields angelicin. | [Toxicity]
The LD50 of angelicin is 322 mg/kg which shows acute toxicity if orally administered to rats. The possible consequences are alteration in circadian rhythm and righting reflex, ataxia and analgesia. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P301+P312+P330-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
LV0940000
| [HS Code ]
29322090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | [Hazardous Substances Data]
523-50-2(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Description]
Angelicin is a furanocoumarin typically isolated from the seeds of P. corylifolia. Like other furanocoumarins, angelicin has antibacterial activities against a number of Gram (+) and Gram (?) bacteria.1 It has also been shown to prevent tacrine-induced cytotoxicity in human liver-derived HepG2 cells (EC50 = 47 μg/ml) and vascular relaxation in phenylephrine-precontracted rat aorta.2,3 Angelicin also weakly inhibits topoisomerase II (IC50 = 404 μM).4 | [Chemical Properties]
White Solid | [Uses]
Antifungal | [Definition]
ChEBI: Angelicin is a furanocoumarin. | [Synthesis Reference(s)]
Tetrahedron, 51, p. 3087, 1995 DOI: 10.1016/0040-4020(95)00070-O | [Clinical Use]
Angelicin derivatives are used to treat psoriasis and cancer. One way of treating these diseases is by photochemotherapy (PUVA) which combines UV irradiation with photosensitizing chemical. Also, it was shown that it is actively inhibits the synthesis of nucleic acids in tumor cells thereby decreasing their growth.
| [References]
[1] NAZNIN A. KHATUNE . Antibacterial compounds from the seeds of Psoralea corylifolia[J]. Fitoterapia, 2004, 75 2: Pages 228-230. DOI: 10.1016/j.fitote.2003.12.018
[2] HYUN CHO1. Bakuchiol: A Hepatoprotective Compound of Psoralea corylifolia on Tacrine-Induced Cytotoxicity in Hep G2 Cells[J]. Planta medica, 2001, 67 1: 750-751. DOI: 10.1055/s-2001-18347
[3] XIANG LI. Bakuchicin induces vascular relaxation via endothelium-dependent NO-cGMP signaling.[J]. Phytotherapy Research, 2011, 25 10: 1574-1578. DOI: 10.1002/ptr.3478
[4] NAN JUN SUN. DNA Polymerase and Topoisomerase II Inhibitors from Psoralea corylifolia[J]. Journal of Natural Products , 2003, 66 5: 734. DOI: 10.1021/np030135t |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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