| Identification | More | [Name]
(R)-(-)-2-Chloromandelic acid | [CAS]
52950-18-2 | [Synonyms]
2-CHLORO-D-MANDELIC ACID
2-CHLORO-MANDELIC ACID (R)
(R)-2-CHLORO-ALPHA-HYDROXYPHENYLACETIC ACID
(R)-(-)-2-CHLOROMANDELIC ACID
(R)-2-CHLOROMANDELIC ACID
(R)-(2-CHLORO-PHENYL)-HYDROXY-ACETIC ACID
(R)-ORTHO-CHLOROMANDELIC ACID
(R-chloromandelicacid)
(R)-(−
)-2-Chloromandelic acid
R-Chloromadelic acid
L-2-Chloromandelic
(r)-2-chloro-à-hydroxyphenylacetic acid
(R)-(-)-2-CHLOROMANDELIC ACID: CHIPROS 99%, EE 99%
(R)-(-)-2-CHLOROMANDELIC ACID 99%
(R )-(-)-2-chloromandellic acid
(R)-(-)-2-Chloromandelic acid, ChiPros 99+%, ee 99+%
(-)-o-Chloro-D-mandelic acid
(2R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid
(R)-2-(2-Chlorophenyl)-2-hydroxyacetic acid
(R)-2-Hydroxy-2-(2-chlorophenyl)acetic acid | [EINECS(EC#)]
-0 | [Molecular Formula]
C8H7ClO3 | [MDL Number]
MFCD00798429 | [Molecular Weight]
186.59 | [MOL File]
52950-18-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
119-121 °C(lit.) | [alpha ]
-125 º (c=3, H2O) | [Boiling point ]
266.91°C (rough estimate) | [density ]
1.48 | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
-124.5 ° (C=3, H2O) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Methanol | [form ]
Solid | [pka]
3.30±0.10(Predicted) | [color ]
Off-White | [Optical Rotation]
[α]23/D 126°, c = 3 in H2O | [BRN ]
2693370 | [InChI]
1S/C8H7ClO3/c9-6-4-2-1-3-5(6)7(10)8(11)12/h1-4,7,10H,(H,11,12)/t7-/m1/s1 | [InChIKey]
RWOLDZZTBNYTMS-SSDOTTSWSA-N | [SMILES]
O[C@@H](C(O)=O)c1ccccc1Cl | [LogP]
1.51 at 23℃ | [Surface tension]
48.7mN/m at 1g/L and 20℃ | [CAS DataBase Reference]
52950-18-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H317-H318 | [Precautionary statements ]
P280-P302+P352-P305+P351+P338+P310 | [Hazard Codes ]
Xi,C | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [REACH Registrations]
Active | [HS Code ]
29181990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Dam. 1
Skin Sens. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
Clopidogrel intermediate. | [Synthesis]
First, 150 mL of toluene was added to a flask equipped with a stirrer and an internal thermometer. Under constant stirring, 0.09 g (0.08 x 10^-3 mol) of the (R,R)-VO salen complex of Example 1 and 21.1 g (0.15 mol) of freshly prepared 2-chlorobenzaldehyde were added sequentially. Subsequently, 10.1 g (0.375 mol) of hydrocyanic acid was added all at once. The resulting dark green homogeneous solution was stirred for 24 h at room temperature in a closed apparatus. The conversion was analyzed by gas chromatography (GC) to be 98% and the enantiomeric excess (ee) value of (S)-2-chloromandelate cyanohydrin was 73%. | [References]
[1] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[2] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[3] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[4] Patent: US2004/236129, 2004, A1. Location in patent: Page 4
[5] Patent: US2004/236129, 2004, A1. Location in patent: Page 4 |
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Alfa Aesar
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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