| Identification | Back Directory | [Name]
3-FORMYL-6-METHYL-PYRIDINE | [CAS]
53014-84-9 | [Synonyms]
5-FORMYL-2-PICOLINE
6-Methylnicotinaldehyde
5-Formyl-2-methylpyridine
3-FORMYL-6-METHYL-PYRIDINE
3-Formyl-6-methyl-pyridine ,97%
6-Methylpyridine-3-carboxaldehyde
6-METHYL-3-PYRIDINECARBOXALDEHYDE
3-Pyridinecarboxaldehyde, 6-methyl-
6-Methylpyridine-3-carboxaldehyde 97%
5-ForMyl-2-picoline/6-Methylnicotinaldehyde
2-Phenyl-[1,2,4]triazolo[1,5-a]pyridin-6-amine
6-Methylpyridine-3-carboxaldehyde, 5-Formyl-2-methylpyridine | [Molecular Formula]
C7H7NO | [MDL Number]
MFCD08272279 | [MOL File]
53014-84-9.mol | [Molecular Weight]
121.14 |
| Chemical Properties | Back Directory | [Boiling point ]
95℃/20mm | [density ]
1.084 | [refractive index ]
1.546 | [Fp ]
88℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
Liquid | [pka]
4.15±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid | [Sensitive ]
Moisture Sensitive | [InChI]
InChI=1S/C7H7NO/c1-6-2-3-7(5-9)4-8-6/h2-5H,1H3 | [InChIKey]
IMWMEIWYPWVABQ-UHFFFAOYSA-N | [SMILES]
C1=NC(C)=CC=C1C=O | [CAS DataBase Reference]
53014-84-9 |
| Questions And Answer | Back Directory | [Application]
3-Aldehyde-6-methylpyridine is a pyridine heterocyclic compound mainly used in laboratory research and development of organic synthesis processes. |
| Hazard Information | Back Directory | [Synthesis]
To a solution of 5-bromo-2-methylpyridine (151; 10 g, 58.1 mmol) in THF (150 mL) was added n-BuLi (2.5 M, 25.6 mL) at -78 ℃. The reaction mixture was stirred at this temperature for Ih. DMF (1.30 mL) was added,, and the resulting reaction mixture was stirred for 1 h at -78 °C. The addition of aq quenched the reaction. NH4Cl. Upon warming to room temperature, the mixture was extracted with EtOAc. The combined organic layers were dried (Na2SO4) and concentrated under reduced pressure. The resulting residue was purified by chromatography to afford 6-methylnicotinaldehyde 152 (5.0 g, 72percent). | [References]
[1] Patent: US2006/287341, 2006, A1. Location in patent: Page/Page column 46
[2] Patent: US2007/4772, 2007, A1. Location in patent: Page/Page column 82
[3] Journal of Medicinal Chemistry, 1989, vol. 32, # 3, p. 583 - 593
[4] Journal of Organic Chemistry, 1988, vol. 53, # 15, p. 3513 - 3521
[5] Patent: US4778796, 1988, A |
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