ChemicalBook--->CAS DataBase List--->53936-56-4

53936-56-4

53936-56-4 Structure

53936-56-4 Structure
IdentificationBack Directory
[Name]

Deoxyarbutin
[CAS]

53936-56-4
[Synonyms]

Deoxyarbutin
Tetrahydropyranyloxyphenol
4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol
Phenol,4-[(tetrahydro-2H-pyran-2-yl)oxy]-
Deoxyarbutin 4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol
[EINECS(EC#)]

1308068-626-2
[Molecular Formula]

C11H14O3
[MDL Number]

MFCD09970981
[MOL File]

53936-56-4.mol
[Molecular Weight]

194.23
Chemical PropertiesBack Directory
[Melting point ]

88-89 °C(Solv: ligroine (8032-32-4))
[Boiling point ]

349.8±32.0 °C(Predicted)
[density ]

1.174
[storage temp. ]

Inert atmosphere,2-8°C
[solubility ]

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
[form ]

Solid
[pka]

10.10±0.15(Predicted)
[color ]

White to Off-White
[Stability:]

Hygroscopic
Safety DataBack Directory
[HS Code ]

2932990090
Hazard InformationBack Directory
[Description]

Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase). It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM. Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM). It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.
[Uses]

Deoxyarbutin acts as a skin whitening agent through the inhibition of tyrosinase. A safer alternative to the use of hydroquinone and arbutin.
[Preparation]

Deoxyarbutin is a derivative of ?-arbutin, obtained by removal of hydroxyl groups from the glucose side-chain of ?-arbutin.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

Deoxyarbutin(53936-56-4)1HNMR
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