| Identification | More | [Name]
Butyramide | [CAS]
541-35-5 | [Synonyms]
AMIDE C4
BUTANAMIDE
BUTYRAMIDE
N-BUTYRAMIDE
butanimidicacid
butanoicacid,amide
Butyricamide
Butyrylamide
n-Butylamide
n-Butyrylamide
n-C3H7C(O)NH2
N-BUTYRAMIDE 99%
Butyramide,98%
n-Butyramide,98% | [EINECS(EC#)]
208-776-4 | [Molecular Formula]
C4H9NO | [MDL Number]
MFCD00041894 | [Molecular Weight]
87.12 | [MOL File]
541-35-5.mol |
| Chemical Properties | Back Directory | [Appearance]
COLORLESS TO WHITE CRYSTALLINE POWDER OR FLAKES | [Melting point ]
114-116 °C | [Boiling point ]
216 °C
| [density ]
1.03
| [FEMA ]
4252 | [refractive index ]
1.4560 | [Fp ]
216°C | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
alcohol: soluble(lit.) | [form ]
powder to crystal | [pka]
16.67±0.40(Predicted) | [color ]
White to Almost white | [Odor]
at 100.00?%. nutty | [Water Solubility ]
soluble | [JECFA Number]
1593 | [Merck ]
14,1592 | [BRN ]
1361528 | [LogP]
-0.210 | [CAS DataBase Reference]
541-35-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Butanamide(541-35-5) | [EPA Substance Registry System]
541-35-5(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
COLORLESS TO WHITE CRYSTALLINE POWDER OR FLAKES | [Chemical Properties]
Yellowish solid; nutty aroma. | [Uses]
Butyramide was used in the synthesis of hydroxamic acids, electrorheological fluids and β-amodoorganotin compounds. It was used as substrate of (+)-γ-lactamase to develop a microreactor to study enzyme stability, activity, kinetics and substrate specificity. | [Definition]
ChEBI: A monocarboxylic acid amide obtained by formal condensation of butanoic acid and ammonia. | [Preparation]
Butyramide is prepared by amination of n-butyric acid. n-Butyric acid is heated with ammonia gas bubbled through it, and the reaction mixture reaches 200–215°C after approximately 40 hours. Heating and ammonia flow are then stopped, and the mixture is cooled below 20°C before filtration to yield butyramide.
An alternative method involves reacting n-butyric acid with urea: First, heat a mixture of 8 kg of n-butyric acid and 3 kg of urea under reflux for 10 hours. Allow the mixture to cool to 70–80°C, then add a suitable amount of hot ethanol. Decolorize the hot solution, filter it while hot, and cool. The crude product obtained by filtration is recrystallised from ethanol to yield the final product. | [Aroma threshold values]
Nutty type odor. |
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