| Identification | More | [Name]
Methoxyphenamine hydrochloride | [CAS]
5588-10-3 | [Synonyms]
2-methoxyphenamine hydrochloride
alpha-(2-methoxyphenyl)-beta-methylaminopropane hydrochloride
LABOTEST-BB LT00772092
METHOXYPHENAMINE HCL
METHOXYPHENAMINE HYDROCHLORIDE
beta-(o-methoxyphenyl)isopropylmethylaminehydrochloride
methoxiphenadrinhydrochloride
methoxyphenaminiumchloride
n,alpha-dimethyl-o-methoxy-phenethylaminehydrochloride
n,alpha-dimethyl-o-methoxy-phenethylaminhydrochloride
o-methoxy-n,alpha-dimethylphenethylaminehydrochloride
o-methoxy-n,alpha-dimethyl-phenethylaminhydrochloride
orthoxinehydrochloride
ortodrinexhydrochloride
2-METHOXY-ALPHA,N-DIMETHYLPHENETHYLAMINE HYDROCHLORIDE
o-Methoxy-N,α-dimethylphenethylamine hydrochloride
2-Methoxymethamphetamine hydrochloride
Benzeneethanamine, 2-methoxy-N,a-dimethyl-, hydrochloride (9CI)
dl-o-Methoxy-N,a-dimethylphenethylamine hydrochloride
dl-Orthoxine hydrochloride | [EINECS(EC#)]
226-993-2 | [Molecular Formula]
C11H18ClNO | [MDL Number]
MFCD00034832 | [Molecular Weight]
215.72 | [MOL File]
5588-10-3.mol |
| Questions And Answer | Back Directory | [Preparation]
o-Methoxyphenyl oxime is synthesized from o-methoxyphenylacetone and monomethylamine in an organic solvent. The o-methoxyphenyl oxime is then reduced with sodium borohydride or potassium borohydride to obtain methoxyphenamine hydrochloride free base. The solution of methoxyphenamine hydrochloride free base is adjusted to pH 2-3 with hydrochloric acid/ethanol solution, and then purified to obtain methoxyphenamine hydrochloride. This invention uses sodium borohydride or potassium borohydride, significantly reducing reaction costs; the reaction conditions are mild, avoiding the possibility of explosion during hydrogenation and the need for precious metal catalysts such as palladium on carbon or platinum required for the hydrogenation process, thus enabling industrial-scale production. |
| Chemical Properties | Back Directory | [Melting point ]
129-131° | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 34 mg/mL (157.61 mM) | [form ]
A crystalline solid | [color ]
Bitter crystals | [InChI]
InChI=1S/C11H17NO.ClH/c1-9(12-2)8-10-6-4-5-7-11(10)13-3;/h4-7,9,12H,8H2,1-3H3;1H | [InChIKey]
FGSJNNQVSUVTPW-UHFFFAOYSA-N | [SMILES]
C1(CC(C)NC)=CC=CC=C1OC.Cl | [CAS DataBase Reference]
5588-10-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
SH8050000
| [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral | [Toxicity]
LD50 orl-rat: 630 mg/kg NIIRDN 6,837,82 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Methoxyphenamine hydrochloride, is the salt version of methoxyphenamine (OMMA), a β-adrenergic receptor agonist, that regulates norephinephrine and ephinephrinein concentrations. | [Definition]
ChEBI: Methoxyphenamine hydrochloride is the hydrochloride salt of methoxyphenamine, a beta-adrenergic receptor agonist that regulates norephinephrine and ephinephrinein concentrations. It is a member of amphetamines and a hydrochloride. It contains a methoxyphenamine. | [Safety Profile]
Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. An FDA over-the-counter drug used as a bronchodilator.When heated to decomposition it emits very toxic fumes of HCl and NOx. |
|
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|