| Identification | Back Directory | [Name]
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate | [CAS]
58168-20-0 | [Synonyms]
strontium ranelate intermediate
StrontiuM ranelate interMediate I
5-amino-4-cyano-3-(2-ethoxy-2-oxoethyL
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)
5-aMino-4-cyano-2-(ethoxycarbonyl)-ethyl ester
Ethyl 5-aMino-4-cyano-3-(2-ethoxy-2-oxoethyl)thioph
5-aMino-4-cy ano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate
Ethyl5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carb...
5-aMino-4-cyano-3-(2-B-cyano-2-carboxyMethyl)-2-thiophene Ethyl
Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxy
ETHYL 5-AMINO-4-CYANO-3-(2-ETHOXY-2-OXOETHYL)THIOPHENE-2-CARBOXYLATE
5-Amino-4-cyano-2-(ethoxycarbonyl)-3-thiopheneacetic acid ethyl ester
3-Thiopheneacetic acid,5-aMino-4-cyano-2-(ethoxycarbonyl)-, ethyl ester
Ethyl 5-AMino-4-cyano-3-(2-ethoxycarbonylMethyl)thiophene-2-carboxylate
Ethyl5-Amino-4-cyano-3-(2-ethoxycarbonylmethyl)thiophene-2-carboxylate>
5-Amino-4-cyano-3-ethoxycarbonylmethyl-thiophene-2-carboxylic acid ethyl ester
5-Amino-4-cyano-3-(2-ethoxycarbonylmethyl)thiophene-2-carboxylic Acid Ethyl Ester | [EINECS(EC#)]
692-648-1 | [Molecular Formula]
C12H14N2O4S | [MDL Number]
MFCD00832845 | [MOL File]
58168-20-0.mol | [Molecular Weight]
282.32 |
| Chemical Properties | Back Directory | [Melting point ]
134-139 °C | [Boiling point ]
469.6±45.0 °C(Predicted) | [density ]
1.31 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
powder to crystal | [pka]
-2.61±0.10(Predicted) | [color ]
Light yellow to Yellow |
| Hazard Information | Back Directory | [Synthesis]
Example 1: Preparation of ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)-2-thiophenecarboxylate (compound of formula II)
1. triethylamine (25 g) was added to a solution of ethanol (75 ml) containing malononitrile (16.33 g) at ambient temperature.
2. Diethyl 3-oxoglutarate (50 g) was added to the above solution, keeping the reaction mixture stirred at 40-45 °C for 1 hour.
3. Sulfur (7.9 g) was added to the reaction mixture and subsequently heated to reflux until the reaction was complete.
4. After completion of the reaction, the reaction material was cooled to ambient temperature and water (400 ml) was slowly added.
5. After stirring the reaction mixture for 1 hour, the product was collected by filtration, washed with water (200 ml) and dried at 40-50 °C.
Yield: 82%. | [References]
[1] Heteroatom Chemistry, 2007, vol. 18, # 3, p. 236 - 238
[2] Patent: WO2013/113319, 2013, A1. Location in patent: Page/Page column 6 |
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