| Identification | More | [Name]
4-Methylphenylacetic acid | [CAS]
622-47-9 | [Synonyms]
4-METHYLPHENYLACETIC ACID
4-TOLYLACETIC ACID
ASISCHEM D13361
P-METHYLPHENYL ACETIC ACID
P-TOLYLACETIC ACID
RARECHEM AL BO 0137
(p-tolyl)-aceticaci
4-Methylbenzeneacetic acid
4-methyl-benzeneaceticaci
4-methylbenzeneaceticacid
Acetic acid, (p-tolyl)-
Benzeneacetic acid, 4-methyl-
p-Tolyacetic acid
4-Methylphylacetic Acid
p-Tolylaceticacid,99%
p-Tolylacetic
4-Methylphenylacetic acid 98%
4-METHYLPHENYLETHANOICACID
P-METHYLPHENYLACETIC ACID/P-TOLYLACETIC ACID
49) PARA METHYL PHENYL ACETIC ACID | [EINECS(EC#)]
210-738-7 | [Molecular Formula]
C9H10O2 | [MDL Number]
MFCD00004353 | [Molecular Weight]
150.17 | [MOL File]
622-47-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white fine crystalline powder | [Melting point ]
88-92 °C (lit.) | [Boiling point ]
265-267 °C (lit.) | [density ]
1.0858 (rough estimate) | [refractive index ]
1.5002 (estimate) | [Fp ]
265-267°C | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
Fine Crystalline Powder | [pka]
pK1:4.370 (25°C) | [color ]
White | [BRN ]
2043528 | [InChI]
InChI=1S/C9H10O2/c1-7-2-4-8(5-3-7)6-9(10)11/h2-5H,6H2,1H3,(H,10,11) | [InChIKey]
GXXXUZIRGXYDFP-UHFFFAOYSA-N | [SMILES]
C1(CC(O)=O)=CC=C(C)C=C1 | [CAS DataBase Reference]
622-47-9(CAS DataBase Reference) | [NIST Chemistry Reference]
p-Tolylacetic acid(622-47-9) |
| Hazard Information | Back Directory | [Chemical Properties]
white fine crystalline powder | [Uses]
p-Tolylacetic acid is a reagent used in the preparation of quaternary amines and epithelial sodium channel inhibition in bronchial epithelium. | [Application]
4-Methylphenylacetic acid is mainly used as a key starting material or reagent for the synthesis of various complex compounds, such as for the preparation of quaternary ammonium salts, and as a precursor for the synthesis of pesticides and pharmaceutical intermediates (such as 4-bromomethylphenylacetic acid and 4-hydroxymethylphenylacetic acid). It is also used in the research of bronchial epithelial sodium channel inhibitors. | [Preparation]
The main method for preparing 4-methylphenylacetic acid is through the hydrolysis of 4-methylphenylacetonitrile (p-tolueneacetonitrile). This method involves hydrolyzing 4-methylphenylacetonitrile under acidic or alkaline conditions to generate the corresponding carboxylic acid. This method is relatively simple to operate and easy to scale up for industrial production. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 48, p. 1919, 1983 DOI: 10.1021/jo00159a031
Tetrahedron Letters, 28, p. 2633, 1987 DOI: 10.1016/S0040-4039(00)96167-7 | [Purification Methods]
Crystallise the acid from heptane or water. [Beilstein 9 IV 1795.] |
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