| Identification | Back Directory | [Name]
Ethyl diazoacetate | [CAS]
623-73-4 | [Synonyms]
Daae
Ethyl diazoate
diazoaceticester
diazoacetate soL
Diazoacetic ester
ETHYL DIAZOACETATE
Ethyl 2-diazoacetate
Ethyl diazoethanoate
Ethylene Diazo Acetate
Diazoacetic acid ethyl
Ethyl Diazoacetate (>
2-Diazoacetic acid ethyl
diazo-aceticaciethylester
Ethyl Diazoacetate (>90%)
diazoaceticacid,ethylester
Ethoxycarbonyldiazomethane
Diazoacetic acid ethyl ester
Diazoessigsaeure-aethylester
Acetic acid, diazo-, ethyl ester
Ethyl diazoacetate solution, 95%
(e)-2-diazonio-1-ethoxyethenolate
Acetic acid, 2-diazo-,ethyl ester
Ethyl diazoacetate ISO 9001：2015 REACH
2-Diazoacetic acid ethyl ester solution
ETHYL DIAZOACETATE ETHYL DIAZOETHANOATE
Ethyl diazoacetate, 95%, contains 5% CH2Cl2
Ethyl diazoacetate solution,90% wt in dichloromethane
Ethyl diazoacetate contains >=13 wt. % dichloroMethane
Ethyl 2-diazoacetate (diluted with ~10% dichloromethane, wt/wt) | [EINECS(EC#)]
210-810-8 | [Molecular Formula]
C4H6N2O2 | [MDL Number]
MFCD00001989 | [MOL File]
623-73-4.mol | [Molecular Weight]
114.1 |
| Chemical Properties | Back Directory | [Appearance]
Liquid. | [Melting point ]
−22 °C(lit.)
| [Boiling point ]
140-141 °C720 mm Hg(lit.)
| [density ]
1.085 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.46(lit.)
| [Fp ]
115 °F
| [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Slightly), DMSO (Soluble), Hexane (Slightly), Methanol (Slightly) | [form ]
Oil | [color ]
Light Yellow to Orange | [Merck ]
13,3021 | [BRN ]
107654 | [NIST Chemistry Reference]
Ethyl diazoacetate(623-73-4) |
| Hazard Information | Back Directory | [Chemical Properties]
Liquid. | [Uses]
Reagent for ruthenium-catalyzed asymmetric cyclopropanation of alkenes.1 | [Hazard]
Flammable liquid that explodes when
heated. | [Purification Methods]
It is a very volatile yellow oil with a strong pungent odour. EXPLOSIVE [distillation even under reduced pressure is dangerous and may result in an explosion — TAKE ALL THE NECESSARY PRECAUTIONS IF DISTILLATION IS TO BE CARRIED OUT]. It explodes in contact with conc H2SO4-trace acid causes rapid decomposition. It is slightly soluble in H2O, but is miscible with EtOH, *C6H6, pet ether and Et2O. To purify, dissolve it in Et2O [using CH2Cl2 instead of Et2O, protects the ester from acid], wash it with 10% aqueous Na2CO3, dry (MgSO4), filter and repeat as many times as possible until the Et2O layer loses its yellow colour, then remove the solvent below 20o (vacuum). Note that prolonged heating may lead to rapid decomposition and low yields. It can also be purified by steam distillation under reduced pressure but with considerable loss in yield. Place the residual oil in a brown bottle, keep below 10o, and use as soon as possible without distilling. For preparing esters usually the ethereal solution is used directly without purification. [Womack & Nelson Org Synth Coll Vol III 392 1955, UV: Miller & White J Am Chem Soc 79 5974 1957, Fieser 1 367 1967, Beilstein 3 IV 1495.] |
| Questions And Answer | Back Directory | [Synthesis]
Glycine ethyl ester hydrochloride can be dissolved in a buffer solution composed of acetic acid and sodium acetate, and then dichloroethane is added as a solvent, and sodium nitrite solution is added dropwise at 10 to 15 ° C. After the dropwise addition, continue stirring for 15min. The separated organic layer is a dichloroethane solution of ethyl diazoacetate.
NH2CH2COOC2H5·HCl+NaNO2+HCl→N2CHCOOC2H5+NaCl+H2O |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,F | [Risk Statements ]
5-10-22-40-67-65-48/20-38-11-63 | [Safety Statements ]
36/37-62-16 | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [RTECS ]
AG5775000
| [HazardClass ]
3.2 | [PackingGroup ]
III | [HS Code ]
29270000 | [Safety Profile]
Poison by ingestion and
intravenous routes. Questionable carcinogen
with experimental carcinogenic and
tumorigenic data. Can explode. Explodes on
contact with tris(dimethy1amino) antimony.
When heated to decomposition it emits
toxic fumes of NOx. See also ESTERS. |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Ethyl acetate-->Glycine ethyl ester hydrochloride-->Permethric acid-->Buffer solution, pH 1.00 (±0.01 at 25°C), No Color, Specpure, NIST Traceable | [Preparation Products]
Ethyl chrysanthemumate-->2,2-Dimethyl-3-(2-methylpropyl)cyclopropanecarboxylic acid p-(methoxymethyl)benzyl ester-->ethyl glycinate-->Ethyl glycolate-->Benzeneacetic acid, α-(hydroxymethylene)-, ethyl ester, (αZ)--->Heptanoic acid, 2-methyl-3-oxo-, ethyl ester-->2-Pentenedioic acid, diethyl ester, (Z)- (9CI)-->2-Oxiranecarboxylicacid, 3-(trichloromethyl)-, ethyl ester-->ETHYL 3-BUTYNOATE-->ETHYL 3-METHOXYPHENYLACETATE-->Ethyl 4-methoxycinnamate-->2-HYDROXYMETHYL-CYCLOPROPANECARBOXYLIC ACID ETHYL ESTER-->Diethyl iminodiacetate-->ethyl 5-(hydroxymethyl)-1H-pyrazole-3-carboxylate |
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