| Identification | Back Directory | [Name]
Dipivefrin hydrochloride | [CAS]
64019-93-8 | [Synonyms]
Progate
Diopine
Pivalephrine
Dipivefrine HCL
dipivefrinhydrochloride
hydrochloride,(+-)-este
dipivefrinehydrochloride
Dipivefrine hydrochloride CRS
dipivalylepinephrinehydrochloride
DIPIVEFRIN HYDROCHLORIDE (200 MG)
Dipivefrin hydrochloride USP/EP/BP
Dipivaloyl epinephrine hydrochloride
propanoicacid,2,2-dimethyl-,4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene
(±)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene dipivalate hydrochloride
4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene bis(2,2-dimethylpropanoate) hydrochloride
Propanoic acid, 2,2-dimethyl-, 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester, hydrochloride
Propanoic acid, 2,2-dimethyl-, 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-phenylene ester, hydrochloride, (+-)-
[2-(2,2-Dimethylpropanoyloxy)-4-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate hydrochloride
Propanoic acid,2,2-diMethyl-, 1,1'-[4-[1-hydroxy-2-(MethylaMino)ethyl]-1,2-phenylene] ester,hydrochloride (1:1) | [EINECS(EC#)]
264-609-5 | [Molecular Formula]
C19H30ClNO5 | [MDL Number]
MFCD01697462 | [MOL File]
64019-93-8.mol | [Molecular Weight]
387.898 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder. | [Melting point ]
158-159° | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Freely soluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent) and in methylene chloride. | [form ]
neat | [pka]
8.40(at 25℃) | [color ]
White to Off-White | [Major Application]
pharmaceutical (small molecule) | [InChI]
InChI=1S/C19H29NO5.ClH/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6;/h8-10,13,20-21H,11H2,1-7H3;1H | [InChIKey]
VKFAUCPBMAGVRG-UHFFFAOYSA-N | [SMILES]
C1(OC(=O)C(C)(C)C)=CC(=CC=C1OC(=O)C(C)(C)C)C(O)CNC.Cl |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder. | [Uses]
Adrenergic (ophthalmic) | [Definition]
ChEBI: The hydrochloride salt of dipivefrin. It is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension. | [Brand name]
Akpro (Akorn); Propine (Allergan). | [Description]
Dipivefrin hydrochloride is an antiglaucoma prothrombotic drug that is hydrolyzed to its active compound epinephrine by esterases in the cornea. | [in vivo]
Dipivefrin hydrochloride (0.3-10 μg/kg; i.p.;) induces enhancement of memory involves central beta- but not alpha-adrenergic mechanisms. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301 | [Precautionary statements ]
P264-P270-P301+P310+P330-P405-P501 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
WGK 3 | [HS Code ]
2922504500 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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AFINE CHEMICALS LIMITED
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www.afinechem.com/index.html |
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