| Identification | More | [Name]
o-Phenanthroline | [CAS]
66-71-7 | [Synonyms]
1,10-PHENANTHROLINE
AKOS 92891
O-PHENANTHROLINE
ORTHOPHENANTHROLINE
1,10-Fenanthrolin
1,10-o-Phenanthroline
4,5-Diazaphenanthrene
4,5-Phenanthroline
Activ-8 in hexylene glycol
beta-Phenanthroline
Solution forms containing 1,10-phenanthroline
1,10-Phenanthroline amhydrous | [EINECS(EC#)]
200-629-2 | [Molecular Formula]
C12H8N2 | [MDL Number]
MFCD00011678 | [Molecular Weight]
180.21 | [MOL File]
66-71-7.mol |
| Chemical Properties | Back Directory | [Appearance]
off-white powder | [Melting point ]
114-117 °C(lit.)
| [Boiling point ]
>330°C | [density ]
1.1836 (rough estimate) | [refractive index ]
1.5200 (estimate) | [Fp ]
>330°C | [storage temp. ]
Store below +30°C. | [solubility ]
2.69g/l | [form ]
Powder | [pka]
4.84(at 25℃) | [color ]
White to light yellow or light pink | [Stability:]
Stable. Hygroscopic. Store under nitrogen. Incompatible with strong acids, strong oxidizing agents. | [Water Solubility ]
slightly soluble | [Sensitive ]
Hygroscopic | [Detection Methods]
HPLC,NMR | [Merck ]
14,7214 | [BRN ]
126461 | [InChI]
1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H | [InChIKey]
DGEZNRSVGBDHLK-UHFFFAOYSA-N | [SMILES]
c1cnc2c(c1)ccc3cccnc23 | [CAS DataBase Reference]
66-71-7(CAS DataBase Reference) | [NIST Chemistry Reference]
o-Phenanthroline(66-71-7) | [EPA Substance Registry System]
66-71-7(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS06,GHS09 | [Signal word ]
Danger | [Hazard statements ]
H301-H410 | [Precautionary statements ]
P264-P270-P273-P301+P310-P391-P405 | [Hazard Codes ]
T,N | [Risk Statements ]
R25:Toxic if swallowed.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
SF8437000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29339990 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Acute 1
Aquatic Chronic 1 | [Safety Profile]
Poison by ingestion and intraperitoneal routes. An experimental teratogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. | [Toxicity]
dni-hmn:leu 5 mg/L ONCOBS 46,193,89 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
o-Phenylenediamine-->8-Aminoquinoline-->1,10-Phenanthroline, 1,2,3,4-tetrahydro--->Pyridine, 3,3'-(1Z)-1,2-ethenediylbis[2-bromo--->2-Amino-3-pyridinecarboxaldehyde-->5 6-EPOXY-5 6-DIHYDRO-(1 10)PHENANTHROL&-->Disodium succinate | [Preparation Products]
1 10-PHENANTHROLINE-5 6-DIONE 97-->2,9-dibromo-1,10-phenanthroline-5,6-dione-->SODIUM 2,4-PENTANEDIONATE-->1,10-Phenanthroline-5,6-dione,3,8-dibromo-->5,6-Dimethyl-1,10-phenanthroline-->2-Methoxybenzyl alcohol-->2,2'-Bicinchoninic Acid-->2,9-Dichloro-1,10-phenanthroline |
| Hazard Information | Back Directory | [Description]
o-Phenanthroline is a white crystalline powder and serves as an organic intermediate. It has multiple uses, acting as both a redox indicator and a reagent for the determination of various metals such as ferrous, palladium, vanadium, copper, and iron.
| [Chemical Properties]
Monohydrate is a white crystalline powder. The melting point is 93-94°C, the melting point of anhydrous is 117°C, soluble in 300 parts of water, 70 parts of benzene, soluble in alcohol and acetone.
| [Characteristics]
o-Phenanthroline can form complexes with a variety of transition metals. Since the complexes formed are chelates, they are relatively stable. The complexes and their derivatives formed with copper can be used as non-oxidative nucleic acid cleaving enzymes because they have certain cleavage activity on DNA, and further have certain anticancer activities. | [Uses]
As an analytical reagent for determination of metals in chemical and biological systems through complex formation. As an indicator ("Ferroin") in combination with ferrous ions for oxidation/reduction reactions. In organic syntheses as an activator. | [Definition]
ChEBI: 1,10-phenanthroline is a phenanthroline. It has a role as an EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor and an EC 2.7.1.1 (hexokinase) inhibitor. | [Preparation]
1,10-Phenanthroline is prepared by heating o-phenylenediamine, glycerin, nitrobenzene and concentrated sulfuric acid. | [in vitro]
proteolysis of lamins, which are the intermediate filament proteins providing support to the nuclear structural proteins and are targets of mmp-2, o-phenanthroline abolished the proteolysis of lamin a [2]. | [storage]
Desiccate at RT | [Purification Methods]
Purify it via the HgCl2 addition compound formed when phenanthridine (20g) in 1:1 HCl (100mL) is added to aqueous HgCl2 (60g in 3L), and the mixture is heated to boiling. The HgCl2 complex separates as yellow red crystals with m 195-198o [Arcus & Mesley J Chem Soc 1780 1953]. Conc HCl is then added until all of the solid has dissolved. The compound separates on cooling and is decomposed with aqueous NaOH (ca 5M). Phenanthridine is extracted into Et2O, evaporated, and the residue is crystallised from pet ether (b 80-100o) or EtOAc. [Cumper et al. J Chem Soc 45218 1962.] It is also purified by chromatography on activated alumina from *benzene solution, with diethyl ether as eluent. Evaporation of ether gives crystalline material which is freed from residual solvent under vacuum, then further purified by fractional crystallisation, under N2, from its melt. It was purified by zone melting and sublimes in a vacuum. The picrate has m 218.5-219.5o (from iso-PrOH) (also reported are m 244-245o and 247-248o, from EtOH or H2O). [Slough & Ubbelhode J Chem Soc 911 1957.] [Beilstein 20 H 466, 20 III/IV 4016, 20/8 V 223.] |
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