| Identification | More | [Name]
4-Hydroxy-3-methoxybenzylamine hydrochloride | [CAS]
7149-10-2 | [Synonyms]
4-AMINOMETHYL-2-METHOXYPHENOL HYDROCHLORIDE
4-HYDROXY-3-METHOXYBENZYLAMINE HCL
4-HYDROXY-3-METHOXYBENZYLAMINE HYDROCHLORIDE
N-VANILLYLAMINE HYDROCHLORIDE
TIMTEC-BB SBB003667
VANILLYLAMINE HCL
VANILLYLAMINE HYDROCHLORIDE
4-Aminomethyl-2-methoxy-phenol Hydrochloride；
Vanillyamine hydrochloride
Vanilylamine hydrochloride
4-(AMINOMETHYL)-2-METHOXYPHENOL HCl
3-Methoxy-4-hydroxybenzylamine Hydrochloride
α-Aminocreosol Hydrochloride
a-Aminocreosol Hydrochloride
4-Hydroxy-3-methoxybenzylamine hydrochloride ,98% | [EINECS(EC#)]
230-468-3 | [Molecular Formula]
C8H12ClNO2 | [MDL Number]
MFCD00012864 | [Molecular Weight]
189.64 | [MOL File]
7149-10-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
219-221 °C (dec.)(lit.)
| [storage temp. ]
Store below +30°C. | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly) | [form ]
Powder | [color ]
Off-white | [Sensitive ]
Moisture Sensitive | [Usage]
A metabolite of Capsaicin | [Detection Methods]
HPLC | [BRN ]
3915418 | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C8H11NO2.ClH/c1-11-8-4-6(5-9)2-3-7(8)10;/h2-4,10H,5,9H2,1H3;1H | [InChIKey]
PUDMGOSXPCMUJZ-UHFFFAOYSA-N | [SMILES]
C1(OC)=C(O)C=CC(CN)=C1.Cl | [LogP]
5.4 at 30℃ | [CAS DataBase Reference]
7149-10-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29214990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
A metabolite of Capsaicin | [Synthesis]
The preparation method of the present invention for the preparation of vanillin amine hydrochloride is described in detail in the following steps: A, 4-hydroxy-3-methoxybenzaldehyde oxime was used as raw material, and ethanol was used as solvent; firstly, 133.6 g (0.80 mol) of 4-hydroxy-3-methoxybenzaldehyde oxime was added into a 2L three-necked flask fitted with a stirrer and a thermometer, and then 1,400mL of ethanol and 13.0 g of an aluminum-zinc Nickel composite catalyst, under the condition of passing hydrogen for protection, heating to 40°C, the reaction for 8 hours; B, after the completion of the reaction filtration (the filtrate residue is the unreacted catalyst, can be recycled), in the filtrate add 70mL of hydrochloric acid with a mass concentration of 30%, adjusting the filtrate pH to 1, precipitated white crystals, filtration to isolate the white crystals, drying in vacuum, to obtain vanillin amine hydrochloride 136.8 g, yield 90.5%. | [References]
[1] Polymer, 2011, vol. 52, # 9, p. 1908 - 1916
[2] Journal of Organic Chemistry, 1988, vol. 53, # 5, p. 1064 - 1071
[3] Patent: CN106366004, 2017, A. Location in patent: Paragraph 0017-0028
[4] Patent: JP2005/527478, 2005, A. Location in patent: Page/Page column 4
[5] Russian Chemical Bulletin, 2018, vol. 67, # 8, p. 1394 - 1400 |
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