| Identification | More | [Name]
Tolperisone | [CAS]
728-88-1 | [Synonyms]
AKOS 91983
TOLPERISONE
1-piperidino-2-methyl-3-(p-tolyl)-3-propanone
2,4’-dimethyl-3-piperidino-propiophenon
2-methyl-3-piperidino-1-p-tolylpropan-1-one
mydeton
2'4-Dimethyl-3-PiperidylPropiophenone
1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-(9CI)
dl-Tolperisone
Mideton
Mydetone
NSC 107321
Propiophenone, 2,4'-dimethyl-3-piperidino-(7CI, 8CI)
Tolperisone (base and/or unspecified salts)
2,4'-Dimethyl-3-piperidinopropiophenone
2-Methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone
α,4'-Dimethyl-β-piperidinopropiophenone | [EINECS(EC#)]
211-976-4 | [Molecular Formula]
C16H23NO | [MDL Number]
MFCD00242995 | [Molecular Weight]
245.36 | [MOL File]
728-88-1.mol |
| Questions And Answer | Back Directory | [Application]
It dilates blood vessels and centrally relaxes muscles. It directly dilates vascular smooth muscle and inhibits polysynaptic reflexes, reduces skeletal muscle tone, relieves muscle rigidity and clonus caused by brain and spinal cord injuries, and increases peripheral blood flow. It is rapidly absorbed orally, reaching peak absorption in 1-2 hours. Clinically, it is used to treat occlusive vascular diseases such as atherosclerosis and endovascular inflammation; it is also used to treat post-stroke sequelae, cerebral palsy, and spinal cord and peripheral nerve diseases. It has a certain therapeutic effect on symptoms such as headache, dizziness, insomnia, limb numbness, memory loss, and tinnitus caused by cerebrovascular diseases. |
| Hazard Information | Back Directory | [Originator]
Tolperisone hydrochloride,Shanghai Abochem
Chemical Co. | [Definition]
ChEBI:2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone is an aromatic ketone. | [Manufacturing Process]
To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added
an excess of thionyl chloride and the reaction mixture refluxed until
completed. It was then taken to dryness under reduced pressure and the
residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate.
An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine
hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered
palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone
was purified by distilling the base (boiling point 106-107°C/1 mm) and
reconverting to the hydrochloride, melting point 216-217°C. | [Brand name]
Tolperisone Hydrochloride
is JAN. | [Therapeutic Function]
Muscle relaxant, Vasodilator | [Synthesis Reference(s)]
Chemical and Pharmaceutical Bulletin, 42, p. 1676, 1994 DOI: 10.1248/cpb.42.1676 |
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