| Identification | More | [Name]
(R)-(+)-2-Chloropropionic acid | [CAS]
7474-05-7 | [Synonyms]
D-2-CHLOROPROPIONIC ACID
D-(A)-CHLOROPROPIONIC ACID
D-ALPHA-CHLOROPROPIONIC ACID
(R)-(+)-2-CHLOROPROPANOIC ACID
(R)-(-)-2-CHLOROPROPIONIC ACID
(R)-(+)-2-CHLOROPROPIONIC ACID
R-2-CHLOROPROPIONIC ACID
(R)-(+)-2-CHLOROPROPIONOIC ACID
(2R)-2-Chloropropionic Acid
D-Chloropropionic Aci
Propanoic acid, 2-chloro-, (2R)-
D-Chloropropionic Acid | [EINECS(EC#)]
626-432-5 | [Molecular Formula]
C3H5ClO2 | [MDL Number]
MFCD00064204 | [Molecular Weight]
108.52 | [MOL File]
7474-05-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Colourless Oil | [Melting point ]
-12°C | [alpha ]
14 º (neat) | [Boiling point ]
185-188 °C (lit.) | [density ]
1.258 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.4345(lit.)
| [Fp ]
140 °F
| [storage temp. ]
−20°C
| [solubility ]
soluble in Chloroform, Methanol | [form ]
clear liquid | [pka]
2.96±0.10(Predicted) | [color ]
Colorless to Almost colorless | [Optical Rotation]
[α]20/D +14°, neat | [BRN ]
1720258 | [InChI]
1S/C3H5ClO2/c1-2(4)3(5)6/h2H,1H3,(H,5,6)/t2-/m1/s1 | [InChIKey]
GAWAYYRQGQZKCR-UWTATZPHSA-N | [SMILES]
C[C@@H](Cl)C(O)=O | [CAS DataBase Reference]
7474-05-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R22:Harmful if swallowed.
R35:Causes severe burns. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2511 8/PG 3
| [WGK Germany ]
3
| [REACH Registrations]
Active | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29159000 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Corr. 1A |
| Hazard Information | Back Directory | [Chemical Properties]
Colourless Oil | [Uses]
(R)-(+)-2-Chloropropionic acid can be used as a starting material in the synthesis of:???????
- Thiolactic acid, a key intermediate, which is used for the preparation of 2(R),5(S)-oxathiolanones by reacting with pivalaldehyde.???????
- (R)-2-chloropropionyl chloride, a key intermediate, which is utilized in the synthesis of (R)-4,5-dihydro-5-methylpyridazin-3(2H)-one derivative with pyrazolopyridine ring as a potential phosphodiesterase inhibitor.???????
- 2-Chloropropionamide derivatives as protein disulfide isomerase (PID) inhibitors.
| [Synthesis]
(1) Under the action of acyltransferase, DL-acetylalanine was used to obtain a-chloropropionic acid by Fischer's method, and L-chloropropionic acid and D-chloropropionic acid were obtained by distillation separation through Podbielniak Column. |
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