ChemicalBook--->CAS DataBase List--->598-78-7

598-78-7

598-78-7 Structure

598-78-7 Structure
IdentificationMore
[Name]

2-Chloropropionic acid
[CAS]

598-78-7
[Synonyms]

2-CHLOROPROPANOIC ACID
(+/-)-2-CHLOROPROPIONIC ACID
2-CHLOROPROPIONIC ACID
ALPHA-CHLOROPROPIONIC ACID
RARECHEM AL BO 1240
(R,S)-2-Chloro-propionicacid
2-chloro-propanoicaci
2-chloropropionic
2-chloro-propionicaci
2-chloroproprionic acid
alpha-chloro-propionicaci
alpha-Monochloropropionic acid
alpha-monochloropropionicacid
-Chloropropanoicacid
Propionic acid, 2-chloro-
Propionic acid, alpha-chloro-
(±)-2-Chloropropionicacid,97%
A-CHLOROPROPIONIC ACID
Propanoic acid, 2-chloro-
(n)-2-chloropropionic acid
[EINECS(EC#)]

209-952-3
[Molecular Formula]

C3H5ClO2
[MDL Number]

MFCD00004224
[Molecular Weight]

108.52
[MOL File]

598-78-7.mol
Chemical PropertiesBack Directory
[Appearance]

colourless liquid
[Melting point ]

-12--14 °C
[mp ]

-12--14 °C
[Boiling point ]

170-190 °C(lit.)
[bp ]

170-190 °C(lit.)
[density ]

1.182 g/mL at 25 °C(lit.)
[vapor pressure ]

4 mm Hg ( 20 °C)
[refractive index ]

n20/D 1.4345(lit.)
[Fp ]

215 °F
[storage temp. ]

Store below +30°C.
[solubility ]

H2O: soluble
[pka]

2.96±0.10(Predicted)
[PH]

<1 (200g/l, H2O, 20℃)
[Stability:]

Stable. Incompatible with strong oxidizing agents, strong bases.
[Water Solubility ]

freely soluble
[BRN ]

1720259
[Uses]

Intermediate for weed killers.
[CAS DataBase Reference]

598-78-7(CAS DataBase Reference)
[NIST Chemistry Reference]

Propanoic acid, 2-chloro-(598-78-7)
[EPA Substance Registry System]

598-78-7(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

C
[Risk Statements ]

R22:Harmful if swallowed.
R35:Causes severe burns.
R21/22:Harmful in contact with skin and if swallowed .
[Safety Statements ]

S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
[RIDADR ]

UN 2511 8/PG 3
[WGK Germany ]

1
[RTECS ]

UE8575000
[TSCA ]

Yes
[HazardClass ]

8
[PackingGroup ]

III
[HS Code ]

29159080
[Safety Profile]

Poison by skin contact. A corrosive. Combustible when exposed to heat or flame. To fight fire, use water, foam, alcohol foam. When heated to decomposition it emits toxic fumes of Cl-. See also 3-CHLOROPROPIONIC ACID.
[Hazardous Substances Data]

598-78-7(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Chlorine-->Propionic acid-->2-Chloro-1-propanol-->α-Chloroethyl Phenyl Sulfoxide-->2-Chloroacrylic acid-->CHLOROPROPANAL-->L(+)-Lactic acid
[Preparation Products]

L-Alanine-->DL-Alanine-->NAPROANILIDE-->Ibuprofen-->Napropamide-->Dichlorprop-->N,N-Diethyl-2-chloropropionamide-->2-CHLORO-N-(2-METHYLPHENYL)PROPANAMIDE
Hazard InformationBack Directory
[General Description]

A pale liquid with a slight odor. Sinks in and mixes with water. Only aluminum, stainless steel or steel covered with a protective lining or coating may contact the liquid or vapor.
[Reactivity Profile]

2-CHLOROPROPIONIC ACID(598-78-7) is neutralized in exothermic reactions by all bases. Reacts with aqueous solutions containing a chemical base and dissolves if neutralization generates a soluble salt. May react with active metals to form gaseous hydrogen and a metal salt. May corrode or dissolve iron, steel, and aluminum parts and containers. Reacts with cyanide salts to generate gaseous hydrogen cyanide. Reacts with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides to generate flammable and/or toxic gases and heat. Reacts with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reacts with carbonates and bicarbonates to generate a harmless gas (carbon dioxide) but some heat. Can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. May initiate polymerization reactions or catalyze other chemical reactions. Fire produces highly toxic chloride fumes [USCG, 1999].
[Air & Water Reactions]

Water soluble.
[Hazard]

Combustible. Toxic by skin contact. Male reproductive damage.
[Health Hazard]

Harmful if inhaled. Irritating to throat. May cause severe skin and eye burns. Harmful if absorbed through skin.
[Chemical Properties]

colourless liquid
[Biochem/physiol Actions]

2-Chloropropionic acid on oral administration induces necrosis of granule cell layer of rat cerebellum.
[Purification Methods]

Dry it with P2O5 and fractionally distil it under vacuum. [Beilstein 2 IV 745.]
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

2-Chloropropionic acid(598-78-7).msds
Questions And AnswerBack Directory
[Description]

2-Chloropropionic acid is a colorless to white crystalline solid or liquid that is denser than water; therefore, can sink and mix with water. It has a slight odor and is the simplest chiral chlorocarboxylic aid.
[Preparation]

2-Chloropropionic acid is prepared from diazotization of L-alanine in hydrochloric acid.
[Application]

2-Chloropropionic acid is employed in the production of propargyl 2-chloropropionate (PCP), which is an atom transfer radical polymerization (ATRP) initiator, by the esterification of propargyl alcohol.

The chemical is also used in the synthesis of benzimidazole derivatives when treated with o-phenylenediamine phosphate.

It can also be used in the preparation of biologically active chitin derivative (1-carboxyethyl) chitosan.

It is used as a building block for the preparation of herbicides, dyestuffs, pesticides, as well as forestand agro-chemicals.
[Biochemical Action]

2-Chloropropionic acid induces necrosis of granule cell layer of rat cerebellum when administered orally.
[Safety]

2-Chloropropionic acid is a neurotoxin, as such it should be handled with utmost care. When inhaled, the chemical can irritate the nose, throat, and lungs, causing wheezing and coughing.

The chemical is a corrosive substance, which may occur by ingestion. Contact of the chemical with the eyes and skin may cause pain, irritation, redness, and severe burns.
Spectrum DetailBack Directory
[Spectrum Detail]

2-Chloropropionic acid(598-78-7)MS
2-Chloropropionic acid(598-78-7)1HNMR
2-Chloropropionic acid(598-78-7)13CNMR
2-Chloropropionic acid(598-78-7)IR1
2-Chloropropionic acid(598-78-7)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

2-Chloropropionic acid, 95%(598-78-7)
[Alfa Aesar]

(+/-)-2-Chloropropionic acid, 97%(598-78-7)
[Sigma Aldrich]

598-78-7(sigmaaldrich)
[TCI AMERICA]

2-Chloropropionic Acid,>98.0%(GC)(T)(598-78-7)
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