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75438-57-2

75438-57-2 Structure

75438-57-2 Structure
IdentificationMore
[Name]

Moxonidine
[CAS]

75438-57-2
[Synonyms]

4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL
4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-3h-pyrimidin-2-amine hydrochloride
4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE
BDF-5895 HCL
MOXONIDINE
MOXONIDINE HCL
MOXONIDINE HYDROCHLORIDE
4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamin
bdf5895
be5895
Moxonidin
4-Chloro-5-(2-imidazolin-2-ylamino)-6-methoxy-2-methylpyrimidine
MOXONIDINE/4-CHLORO-N-(4,5-DIHYDRO-1H-2-IMIDAZOLYL)-6-METHOXY-2-METHYL-5-PYRAMINE
4-Chloro-N-(4,5-dihydro-1H-imidaml-2-y1)-6-methoxy-2-methyl-5-pyrimidinamine
Cynt
Physioterls
4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine
4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine
Norcynt
[Molecular Formula]

C9H13Cl2N5O
[MDL Number]

MFCD06795643
[Molecular Weight]

278.14
[MOL File]

75438-57-2.mol
Chemical PropertiesBack Directory
[CAS DataBase Reference]

75438-57-2(CAS DataBase Reference)
Safety DataBack Directory
[WGK Germany ]

3
[RTECS ]

UV6260290
Raw materials And Preparation ProductsBack Directory
【Raw materials】

Ethylenediamine-->Ammonium thiocyanate-->4,5-dihydro-1H-imidazole-->4,6-Dichloro-2-methylpyrimidine
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Moxonidine(75438-57-2).msds
Questions And AnswerBack Directory
[Description]

Moxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.
Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.
It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity.
It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.
[Physical and Chemical Properties]

ensity: 1.52g/cm3, boiling point:  364.7 °C at 760 mmHg, flash point: 174.3 °C, crystallization, melting point: 217-219 degrees Celsius.
[Application]

  • By stimulating the central presynaptic alpha 2-receptor and onset, and its antihypertensive effect of ACE inhibitors, calcium antagonists nifedipine and captopril similar. Treatment of essential hypertension.
  • The intervention of renal interstitial fibrosis can protect the kidney.
[Preparation]

5-amino-4,6-dichloro-2-methyl pyrimidine and 1-acetyl-2-imidazolin-2-one. The product, reacting with sodium methanol can produce moxonidine.
[Precautions]

  • There may be dry mouth, fatigue and headache at the beginning of treatment, occasional dizziness, insomnia, and weakness in the legs and so on.
  • Sick sinus syndrome, the sinus node and atrioventricular Ⅱ-Ⅲ degree block, resting bradycardia (50 beats/min), unstable angina, severe liver disease, progressive renal dysfunction, angioedema patients should not use it.
[References]

https://en.wikipedia.org/wiki/Moxonidine
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