| Identification | Back Directory | [Name]
Cefbuperazone | [CAS]
76610-84-9 | [Synonyms]
Tomiporan
Keiperazon
CEFBUPERAZONE
The side chain of Cefbuperazone
methyl-1h-tetrazol-5-yl)thio)methyl)-8-oxo-,(6r-(6-alpha,7-alpha,7(2r*,3s*))
5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-((2-(((4-ethyl-2,3-dio
xo-1-piperazinyl)carbonyl)amino)-3-hydroxy-1-oxobutyl)amino)-7-methoxy-3-(((1-
(6R,7S)-7-((2R,3S)-2-(4-Ethyl-2,3-dioxo-1-piperazinecarboxamido)-3-hydroxybutyramido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R,3S)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-3-hydroxy-1-oxobutyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7S)-
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-3-hydroxy-1-oxobutyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, [6R-[6α,7α,7(2R*,3S*)]]- | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C22H29N9O9S2 | [MDL Number]
MFCD00864869 | [MOL File]
76610-84-9.mol | [Molecular Weight]
627.65 |
| Chemical Properties | Back Directory | [Melting point ]
118-120° (dec) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Chemical Properties]
Solid, melting point 118-120°C (decomposition).
Cefbuperaxone Sodium: C22H28N9O9S2NaO [76648-01-6]. White to pale yellowish white powder, odorless, slightly bitter. Very soluble in water, freely soluble in methanol, slightly soluble in ethanol, practically insoluble in ether. | [Uses]
Cefbuperazone is a second-generation cephalosporin antibiotic. | [Definition]
ChEBI: Cefbuperazone is a second-generation cephamycin antibiotic having [(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl and {N-[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]-D-threonyl}amino side groups located at positions 3 and 7beta respectively. It is a peptide and a cephalosporin. | [Antimicrobial activity]
Cefbuperazone is a semisynthetic cephamycin antibiotic with properties similar to those of cefoxitin, but somewhat more active against B. fragilis and enterobacteria. It is not hydrolyzed by common β-lactamases and as a result its activity is not affected by inoculum size. It is not active against cefoxitin-resistant strains. It is available in Japan. |
|
|