| Identification | More | [Name]
N-Ethyl-p-toluenesulfonamide | [CAS]
80-39-7 | [Synonyms]
ETSM
N-E-PTSA
N-ETHYL-P-TOLUENESULFONAMIDE
N-Ethyltoluene-4-sulphonamide
N-ETHYL-TOLUENESULFONAMIDE
Benzenesulfonamide, N-ethyl-4-methyl-
Ethyl toluenesulfonamide
Ethylp-toluenesulfonamide
n-ethyl-4-methyl-benzenesulfonamid
n-ethyl-4-methylbenzenesulfonamide
N-Ethyl-4-methyl-benzenesulfonamide
n-ethyl-4-toluenesulfonamide
N-Ethyl-p-methylbenzenesulfonamide
N-Ethyl-p-tolylsulfonamide
N-Tosylethylamine
p-Tolueneethylsulfonamide
p-Toluenesulfonamide, N-ethyl-
p-Toluenesulfonyl-N-ethylamide
Santicizer 3
Unipex 108 | [EINECS(EC#)]
201-275-1 | [Molecular Formula]
C9H13NO2S | [MDL Number]
MFCD00048511 | [Molecular Weight]
199.27 | [MOL File]
80-39-7.mol |
| Chemical Properties | Back Directory | [Appearance]
off-white crystalline solid | [Melting point ]
63-65 °C(lit.)
| [Boiling point ]
208 °C745 mm Hg(lit.)
| [density ]
1.26 g/cm3 | [refractive index ]
1.5270 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
11.86±0.50(Predicted) | [color ]
White to Off-White | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Cosmetics Ingredients Functions]
FILM FORMING
PLASTICISER | [InChI]
InChI=1S/C9H13NO2S/c1-3-10-13(11,12)9-6-4-8(2)5-7-9/h4-7,10H,3H2,1-2H3 | [InChIKey]
OHPZPBNDOVQJMH-UHFFFAOYSA-N | [SMILES]
C1(S(NCC)(=O)=O)=CC=C(C)C=C1 | [LogP]
1.960 (est) | [Uses]
Plasticizer. | [CAS DataBase Reference]
80-39-7(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Toluenesulfonamide, n-ethyl-(80-39-7) | [EPA Substance Registry System]
80-39-7(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29350090 | [Storage Class]
13 - Non Combustible Solids |
| Hazard Information | Back Directory | [General Description]
Platelets (from dilute alcohol or ligroin) or off-white solid. | [Reactivity Profile]
An amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). | [Air & Water Reactions]
Insoluble in water. | [Fire Hazard]
Flash point data for this chemical are not available; however, N-ETHYL-4-METHYLBENZENE SULFONAMIDE is probably combustible. | [Description]
N-Ethyl-p-toluenesulfonamide (N-PTSA) is a white crystal commonly used as a pharmaceutical intermediate. It is synthesized by reacting ethyl acetoacetate with p-toluenesulfonyl chloride under alkaline conditions. In the pharmaceutical industry, N-PTSA is utilized in the synthesis of various drugs. The presence of ethyl and p-toluenesulfonamide groups in its structure makes N-PTSA valuable for specific applications in drug synthesis. Additionally, N-PTSA is employed as a plasticiser to enhance polymers more reactivity[1]. | [Chemical Properties]
off-white crystalline solid | [References]
[1] Xiao Bian . (2025). Solubility, solvent effects and thermodynamic properties of N-Ethyl-p-toluenesulfonamide in twelve pure organic solvents. Journal of the Taiwan Institute of Chemical Engineers, 170, Article 106009. https://doi.org/10.1016/j.jtice.2025.106009 |
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