| Identification | More | [Name]
Acetrizoic acid | [CAS]
85-36-9 | [Synonyms]
2,4,6-TRIIODO-3-ACETAMIDOBENZOIC ACID
3-ACETAMIDO-2,4,6-TRIIODOBENZOIC ACID
3-ACETAMINO-2,4,6-TRIIODOBENZOIC ACID
3-ACETYLAMINO-2,4,6-TRIIODOBENZOIC ACID
ACETRIAZOIC ACID
ACETRIZOIC ACID
3-(acetylamino)-2,4,6-triiodo-benzoicaci
3-acetamido-2,4,6-triiodo-benzoicaci
Acido 3-acetilamino-2,4,6-triiodobenzoico
acido3-acetilamino-2,4,6-triiodobenzoico
Benzoic acid, 3-(acetylamino)-2,4,6-triiodo-
Benzoic acid, 3-acetamido-2,4,6-triiodo-
Benzoicacid,3-(acetylamino)-2,4,6-triiodo-
opacaron
urokon
urokonicacid
2,4,6-Triiodo-3-acetylaminobenzoic acid | [EINECS(EC#)]
201-600-7 | [Molecular Formula]
C9H6I3NO3 | [MDL Number]
MFCD00016495 | [Molecular Weight]
556.86 | [MOL File]
85-36-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
280-280.5 °C (decomp) | [Boiling point ]
547.1±50.0 °C(Predicted) | [density ]
2.5688 (estimate) | [storage temp. ]
2-8°C(protect from light) | [solubility ]
It is soluble in alcohol, slightly soluble in ether and water, very slightly soluble in chloroform and practically insoluble in benzene. | [form ]
powder to crystal | [pka]
1.13±0.10(Predicted) | [color ]
White power | [Water Solubility ]
1.28g/L(25 ºC) | [CAS DataBase Reference]
85-36-9(CAS DataBase Reference) | [NIST Chemistry Reference]
3-Acetamido-2,4,6-triiodobenzoic acid(85-36-9) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RTECS ]
DG0887000 | [HS Code ]
2924.29.7790 | [Toxicity]
LD50 orl-mus: 20 g/kg FRPSAX 18,33,63 |
| Hazard Information | Back Directory | [Chemical Properties]
Acetrizoic acid is an ionic monomeric contrast medium. It was first synthesized by Wallingford in 1953 and it was filled in the FDA by the Johnson & Johnson subsidiary, Cilag Chemie AG, on February 8th, 1978.Acetrizoic acid presents, in the FDA records, a category of drug substance with an inactive status. | [Uses]
Radiopaque agent: Acetrizoic acid (trade names Gastrografina, Urografina in Portugal) is a palatable lemon-flavored water-soluble iodinated radiopaque X-ray contrast medium for oral or rectal administration only. Acetrizoic acid is indicated for radiographic examination of segments of the gastrointestinal tract (esophagus, stomach, proximal small intestine, and colon). The preparation is particularly indicated when a more viscous agent such as barium sulfate, which is not water-soluble, is not feasible or is potentially dangerous. Administration of hypertonic Gastrografin solutions may lead to hypovolemia and hypotension due to fluid loss from the intestine.
| [Definition]
ChEBI: Acetrizoic acid is an aminobenzoic acid. | [Indications]
Acetrizoic acid indication was to be used as a contrast agent for X-ray. Some information indicates its nephrotropic property as one of the characteristics for the utilization of acetrizoic acid.The X-ray imaging depends on the difference in tissue density which is provided by an X-ray attenuation between the area of interest and the surrounding tissue. The use of contrast agents will provoke a contrast enhancement or opacification and it will improve the differentiation of pathological processes from normal tissue. | [Brand name]
Salpix (Ortho-McNeil). | [Safety Profile]
Mildly toxic by ingestion andintravenous routes. When heated to decomposition it emitstoxic fumes of I- and NOx.
| [storage]
Store at -20°C |
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