| Identification | More | [Name]
Methyl 3-amino-4-methylthiophene-2-carboxylate | [CAS]
85006-31-1 | [Synonyms]
3-AMINO-4-METHYL-2-THIOPHENECARBOXYLIC ACID METHYL ESTER
3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
3-AMINO-4-METHYLTHIOPHENECARBOXYLIC ACID METHYL ESTER
LABOTEST-BB LT00453517
M3A4MT2C
Methyl 3-amino-4-methyl-2-thenoate
METHYL 3-AMINO-4-METHYL-2-THIOPHENECARBOXYLATE
METHYL 3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLATE
2-Thiophenecarboxylic acid, 3-amino-4-methyl-, methyl ester
Methyl 3-Amino-4-Methylthiophen-2-Carboxylate
METHYL 3-AMINO-4-METHYLTHIOPHENE-2-CARBO
3-Amino-4-Methyl-2-ThiophenecarboxylicMethylester
Articaine intermediate E
3-Amino-2-methoxycarbonyl-4-methylthiophene
3-Amino-2-carbomethoxy-4-methylthiophen
3-Amino-4-methylthiophene-2-carboxylic
4-Methyl-3-aminothiophene-2-carboxylic acid methyl ester | [EINECS(EC#)]
285-060-8 | [Molecular Formula]
C7H9NO2S | [MDL Number]
MFCD00051822 | [Molecular Weight]
171.22 | [MOL File]
85006-31-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [WGK Germany ]
2
| [Hazard Note ]
Irritant | [HS Code ]
29349990 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Ethanol-->Sodium hydride-->Hydroxylamine hydrochloride-->Methyl methacrylate-->Methyl thioglycolate-->Methyl 2-Methyl-3-Oxo-Tetrahydrothiophene-2-Carbonate-->4-METHYL-3-AMINO-2-(METHOXYCARBONYL)-4,5-DIHYDROTHIOPHENE | [Preparation Products]
Thieno[3,2-d]pyrimidine-7-carboxylic acid, 4-chloro--->METHYL 3-CHLORO-4-METHYLTHIOPHENE-2-CARBOXYLATE-->Methyl 3-dimethylamino-4-methylthiophene-2-carboxylate, 97%-->Thieno[3,2-d]pyriMidine, 2-chloro-7-Methyl-4-(4-Morpholinyl)--->7-(BROMOMETHYL)-2-CHLOROTHIENO[3,2-D]PYRIMIDINE-->7-Methylthieno[3,2-d]pyrimidine-2,4-diol-->tert-butyl 4-methylthiophen-3-ylcarbamate-->5-Chlorothieno[3,2-b]pyridine-3-carboxylic acid |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B. | [Application]
methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine.
7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate.
The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield. | [Definition]
ChEBI: Methyl 3-amino-4-methylthiophene-2-carboxylate is a thiophenecarboxylic acid. |
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