| Identification | More | [Name]
Methyl 3-amino-4-methylthiophene-2-carboxylate | [CAS]
85006-31-1 | [Synonyms]
3-AMINO-4-METHYL-2-THIOPHENECARBOXYLIC ACID METHYL ESTER
3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
3-AMINO-4-METHYLTHIOPHENECARBOXYLIC ACID METHYL ESTER
LABOTEST-BB LT00453517
M3A4MT2C
Methyl 3-amino-4-methyl-2-thenoate
METHYL 3-AMINO-4-METHYL-2-THIOPHENECARBOXYLATE
METHYL 3-AMINO-4-METHYLTHIOPHENE-2-CARBOXYLATE
2-Thiophenecarboxylic acid, 3-amino-4-methyl-, methyl ester
Methyl 3-Amino-4-Methylthiophen-2-Carboxylate
METHYL 3-AMINO-4-METHYLTHIOPHENE-2-CARBO
3-Amino-4-Methyl-2-ThiophenecarboxylicMethylester
Articaine intermediate E
3-Amino-2-methoxycarbonyl-4-methylthiophene
3-Amino-2-carbomethoxy-4-methylthiophen
3-Amino-4-methylthiophene-2-carboxylic
4-Methyl-3-aminothiophene-2-carboxylic acid methyl ester | [EINECS(EC#)]
285-060-8 | [Molecular Formula]
C7H9NO2S | [MDL Number]
MFCD00051822 | [Molecular Weight]
171.22 | [MOL File]
85006-31-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
85-88 °C (lit.) | [Boiling point ]
318.6±37.0 °C(Predicted) | [density ]
1.264±0.06 g/cm3(Predicted) | [Fp ]
>100°C | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
1.71±0.10(Predicted) | [color ]
Pale Yellow | [Water Solubility ]
1g/L at 35℃ | [BRN ]
973196 | [InChI]
1S/C7H9NO2S/c1-4-3-11-6(5(4)8)7(9)10-2/h3H,8H2,1-2H3 | [InChIKey]
YICRPERKKBDRSP-UHFFFAOYSA-N | [SMILES]
COC(=O)c1scc(C)c1N | [LogP]
1.28 | [CAS DataBase Reference]
85006-31-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [WGK Germany ]
2
| [Hazard Note ]
Irritant | [REACH Registrations]
Active | [HS Code ]
29349990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Ethanol-->Sodium hydride-->Hydroxylamine hydrochloride-->Methyl methacrylate-->Methyl thioglycolate-->Methyl 2-Methyl-3-Oxo-Tetrahydrothiophene-2-Carbonate-->4-Methyl-3-amino-2-(methoxycarbonyl)-4,5-dihydrothiophene | [Preparation Products]
Thieno[3,2-d]pyrimidine-7-carboxylic acid, 4-chloro--->Methyl 3-chloro-4-methylthiophene-2-carboxylate-->Methyl 3-dimethylamino-4-methylthiophene-2-carboxylate, 97%-->Thieno[3,2-d]pyriMidine, 2-chloro-7-Methyl-4-(4-Morpholinyl)--->7-(Bromomethyl)-2-chlorothieno[3,2-d]pyrimidine-->7-Methylthieno[3,2-d]pyrimidine-2,4-diol-->tert-butyl 4-methylthiophen-3-ylcarbamate-->5-Chlorothieno[3,2-b]pyridine-3-carboxylic acid |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B. | [Application]
methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine.
7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate.
The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield. | [Definition]
ChEBI: Methyl 3-amino-4-methylthiophene-2-carboxylate is a thiophenecarboxylic acid. |
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