| Identification | More | [Name]
2,4,6-Trimethylaniline | [CAS]
88-05-1 | [Synonyms]
2,4,6-TRIMETHYLANILINE
2,4,6-trimethylbenzenamine
2-AMINO-1,3,5-TRIMETHYLBENZENE
2-AMINOMESITYLENE
AKOS BBS-00003561
AMINOMESITYLENE
LABOTEST-BB LTBB000742
MESIDENE
MESIDINE
MESITYLAMINE
1-amino-2,4,6-trimethylbenzen
1-amino-2,4,6-trimethylbenzen(czech)
1-Amino-2,4,6-trimethylbenzene
2,4,6-trimethyl-anilin
2,4,6-trimethyl-benzenamin
2,4,6-Trimethylphenylamine
2-amino-mesitylen
Aniline, 2,4,6-trimethyl-
aniline,2,4,6-trimethyl-
Benzenamine,2,4,6-trimethyl- | [EINECS(EC#)]
201-794-3 | [Molecular Formula]
C9H13N | [MDL Number]
MFCD00007740 | [Molecular Weight]
135.21 | [MOL File]
88-05-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Aniline, 2,4,6-Trimethyl-is a clear liquid. | [Melting point ]
-5 °C
| [Boiling point ]
108-110 °C11 mm Hg(lit.)
| [density ]
0.963 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.551(lit.)
| [Fp ]
205 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
liquid (clear)
| [pka]
pK1:4.38(+1) (25°C) | [color ]
clear brown
| [Water Solubility ]
IMMISCIBLE | [BRN ]
636559 | [InChIKey]
KWVPRPSXBZNOHS-UHFFFAOYSA-N | [CAS DataBase Reference]
88-05-1(CAS DataBase Reference) | [IARC]
3 (Vol. 27, Sup 7) 1987 | [NIST Chemistry Reference]
Benzenamine, 2,4,6-trimethyl-(88-05-1) | [EPA Substance Registry System]
88-05-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T+,T | [Risk Statements ]
R21/22:Harmful in contact with skin and if swallowed .
R26:Very Toxic by inhalation.
R36/38:Irritating to eyes and skin .
R33:Danger of cumulative effects.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2810 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
BZ0700000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214980 | [Safety Profile]
Poison by inhalation.
Moderately toxic by ingestion. A skin and
severe eye irritant. Questionable carcinogen
with experimental carcinogenic data.
Mutation data reported. When heated to
decomposition it emits toxic fumes of NOx. | [Hazardous Substances Data]
88-05-1(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
A liquid. | [Reactivity Profile]
ANILINE, 2,4,6-TRIMETHYL-neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides. | [Health Hazard]
This material is moderately toxic orally. It is also considered highly toxic by unspecified routes. It is a skin and eye irritant. Suspect occupational carcinogen. (Non-Specific--Aromatic Amines) The danger of acute poisoning is represented by methemoglobinemia leading to adverse effects on the red cells. A number of the amines may act as skin sensitizers. | [Potential Exposure]
Used on small scale in organic
synthesis. | [Fire Hazard]
When heated to decomposition, ANILINE, 2,4,6-TRIMETHYL-emits toxic fumes of nitrogen oxides. Avoid decomposing heat. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical
attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
| [Shipping]
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. | [Chemical Properties]
Aniline, 2,4,6-Trimethyl-is a clear liquid. | [Chemical Properties]
clear yellow to brown liquid | [Uses]
2,4,6-Trimethylaniline is useful for the preparation of Grubbs' catalyst. It is used as a precursor to dyes. It undergoes condensation reaction with glyoxal to prepare glyoxal-bis(mesitylimine). It is also involved in the preparation of 1,3-diketimines ligands by condensation with 1,3-diketones. Further, it is used for the production of Acid Blue 129 dye, which is useful in histochemistry studies. In addition to this, it serves as a building block to various bulky ligands. | [Definition]
ChEBI: 2,4,6-Trimethylaniline is a substituted aniline. | [Preparation]
2,4,6-Trimethylaniline is prepared by selective mononitration of mesitylene, avoiding oxidation of the methyl groups.
Mix sulfuric acid and nitric acid into mixed acid, nitrify with mesitylene at atmospheric pressure below 10°C for 4 hours, stand for stratification, and let off the waste acid. The obtained 2,4,6-trimethylnitrobenzene, iron powder, hydrochloric acid and water were prepared in a ratio of 1:3.74:0.9:2.22 (mol ratio) for reduction reaction at 100-105°C for 8h. Crude 2,4,6-Trimethylaniline was then distilled off from the reduced material and purified by distillation. |
| Spectrum Detail | Back Directory | [Spectrum Detail]
2,4,6-Trimethylaniline(88-05-1)MS
2,4,6-Trimethylaniline(88-05-1)1HNMR
2,4,6-Trimethylaniline(88-05-1)13CNMR
2,4,6-Trimethylaniline(88-05-1)IR1
2,4,6-Trimethylaniline(88-05-1)IR2
2,4,6-Trimethylaniline(88-05-1)Raman
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