| Identification | Back Directory | [Name]
Bendamustine | [CAS]
97832-05-8 | [Synonyms]
Bendamustine
Bendamustine USP/EP/BP
4-[5-[Bis(2-chloroethyl)amino]-1-methyl-benzimidazol-2-yl]butyric acid hydrochloride | [Molecular Formula]
C16H21Cl2N3O2.HCl | [MOL File]
97832-05-8.mol | [Molecular Weight]
394.72 |
| Hazard Information | Back Directory | [Enzyme inhibitor]
This nitrogen mustard and anticancer drug (FWfree-acid = 358.26 g/mol; CAS
16506-27-7), also known by its code name SDX-105, its trade names
Treanda?, Treakisym?, Ribomustin?, and Levact?, as well as by its
systematic name 4-[5-[bis (2-chloroethyl) amino]-1-methylbenzimidazol-2-
yl]butanoic acid, is a relatively nonspecific DNA alkylating agent that
causes intra- and inter-strand cross-links. Bendamustine is used in the
treatment of chronic lymphocytic leukemia (CLL), Hodgkin’s disease, non-
Hodgkin’s lymphoma, multiple myeloma and lung cancer.
Pharmacokinetics: After intravenous infusion, >95% of the drug becomes
protein-bound, mainly to albumin; however, only free bendamustine is
active. Bendamustine is metabolized by liver cytochrome p450, and
elimination (renal) is biphasic, with an initial half-life of 6–10 minutes and a
terminal half-life of approximately 30 minutes. |
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| Company Name: |
China Langchem Inc.
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sgtlifesciences pvt ltd
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AFINE CHEMICALS LIMITED
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SIMAGCHEM CORP
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Ontores Biotech
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www.ontoresinc.cn |
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