213819-48-8
213819-48-8 结构式
基本信息
盐酸贝路替康
贝洛替康盐酸盐
CKD-602 盐酸盐
TOPOISOMERASE I抑制剂(BELOTECAN HYDROCHLORIDE)
(S)-4-乙基-4-羟基-11-(2-(异丙氨基)乙基)-1H-吡喃并[3',4'：6,7]吲哚并[1-2,b]喹啉-3,14(4H,12H)-二酮盐酸盐
(S)-4-乙基-4-羟基-11-[2-(异丙基氨基)乙基]-3,4,12,14-四氢-1H-吡喃并[3',4':6,7]氮茚并[1,2-B]喹啉-3,14-二酮盐酸盐
(S)-4-乙基-4-羟基-11-[2-(异丙基氨基)乙基]-3,4,12,14-四氢-1H-吡喃并[3',4':6,7]中氮茚并[1,2-B]喹啉-3,14-二酮盐酸盐
CKD-602
CKD 602
CKD602
Belotecan Hydrochlorid
Camtobell hydrochloride
BELOTECAN HYDROCHLORIDE
(S)-7-methylcamptothecin
CKD-602: BELOTECAN HYDROCHLORIDE
Belotecan hydrochloride(CKD-602)
(S)-4-Ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol
(S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione hydrochloride
常见问题列表
CKD-602 盐酸盐是一种新型喜树碱衍生物抗肿瘤药物。尽管ckd -602在临床中应用更广泛，但静脉输注引起的ckd -602相关毒性尚未得到评估。
| Target | Value |
|
DNA topoisomerase I
() |
Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC 50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC 50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.
Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.