24168-96-5
中文名称
硝酸异康唑
英文名称
Isoconazole nitrate
CAS
24168-96-5
EINECS 编号
246-051-4
分子式
C18H15Cl4N3O4
MDL 编号
MFCD01721647
分子量
479.14
MOL 文件
24168-96-5.mol
更新日期
2024/04/22 14:22:54
24168-96-5 结构式
基本信息
中文别名
1-[2-(2,4-二氯苯基)-2-[(2,6-二氯苯基)甲氧基]乙基]-1H-咪唑单硝酸盐硝酸异康唑
氯氨酮杂质A
硝酸邻氯益康唑
英文别名
1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1h-imidazole mononitrateISOCONAZOLE NITRATE
1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazolium nitrate
1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-, mononitrate (9CI)
Adestan G 100
Fazol
Gyno-Travogen
Imidazole, 1-[2,4-dichloro-b-[(2,6-dichlorobenzyl)oxy]phenethyl]-, mononitrate (8CI)
R 15454
Travogen
Travogyn
1-(2-(2,4-Dichlorophenyl)-2-((2,6-dichlorophenyl)methoxy)ethyl)-1H-imidazole nitrate
Gyno-travozen
所属类别
原料药：其它抗生素类药物理化学性质
外观性状白色结晶或结晶性粉末，无味，不溶于水，乙醚，稍溶于氯仿，乙醇，熔点178-182°C，比旋度-0.1°- +0.1°
熔点178-182°C
储存条件Sealed in dry,2-8°C
溶解度Very slightly soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent).
形态neat
颜色白色至灰白色
Merck14,5160
常见问题列表
概述
硝酸异康唑是一种具有广谱抗真菌作用的咪唑类抗真菌药，对白色念珠菌、表皮癣菌及某些革兰阳性菌均有抑制作用。硝酸异康唑于1979年在法国上市，因其具有疗效显著，毒副作用低等优点，具有广阔的市场前景。生物活性
Isoconazole nitrate 是一种唑类抗真菌药物。体外研究
Isoconazole nitrate also exerts several other effects on the fungal membrane, which are independent of inhibition of the ergosterol synthesis. Isoconazole nitrate (ISN) causes a rapid reduction of cellular adenosine triphosphate (ATP) within 10 min of in vitro exposure.
Isoconazole nitrate (1, 10 μg/mL) induces a blockade of cell division in vitro by its action on synthesis and organisation of the cell membrane. Isoconazole nitrate (50, 100 μg/mL), ISN induced necrosis and death of fungal cells.