DYRK1B抑制剂(AZ191)
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- CAS号:
- 1594092-37-1
- 英文名:
- AZ191
- 英文别名:
- AZ191;CS-1824;AZ-191;AZ 191;N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine;2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-;[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine;Inhibitor,AZ-191,Dual specificity tyrosine regulated kinase,AZ191,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,AZ 191,DYRK;N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine, AZ191
- 中文名:
- DYRK1B抑制剂(AZ191)
- 中文别名:
- 化合物AZ191;DYRK1B抑制剂(AZ191);AZ 191,DYRK1B抑制剂;N-(2-甲氧基-4-(4-甲基哌嗪-1-基)苯基)-4-(1-甲基-1H-吡咯并[2,3-C]吡啶-3-基)嘧啶-2-胺
- CBNumber:
- CB22716123
- 分子式:
- C24H27N7O
- 分子量:
- 429.52
- MOL File:
- 1594092-37-1.mol
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DYRK1B抑制剂(AZ191)化学性质
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沸点:
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705.3±70.0 °C(Predicted)
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密度:
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1.29±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO: soluble10mg/mL, clear
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形态:
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powder
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酸度系数(pKa):
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7.76±0.42(Predicted)
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颜色:
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white to yellow to light brown
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DYRK1B抑制剂(AZ191)性质、用途与生产工艺
AZ191 是 DYRK1B 高效选择性抑制剂，IC50 值 17 nM。
AZ191 (0.01-60μM; 5 days) inhibits SW872 and SW982 cell lines in dose-dependent manner with IC
50
s of 3.183 μM and 1.279 μM, respectively.
AZ191 (1-5 μM; 48 hours) down-regulates three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations.
Cell Proliferation Assay
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Cell Line:
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SW872, SW982 liposarcoma cells
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Concentration:
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0.01, 0.03, 0.1, 0.3, 0.6, 1, 3, 6, 10, 20, 60 μM
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Incubation Time:
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5 days
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Result:
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Dose-dependent growth inhibition with IC
50
s of 3.183 μM and 1.279 μM for SW872 and SW982 cell lines, respectively.
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Western Blot Analysis
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Cell Line:
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SW872, SW982 liposarcoma cells
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Concentration:
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1, 2, 3, 4, 5 μM
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Incubation Time:
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48 hours
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Result:
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Down-regulated three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations.
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DYRK1B抑制剂(AZ191)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-12277 | AZ191 | | 1 mg | 340元 |
| 2024/01/25 | HY-12277 | DYRK1B抑制剂(AZ191)
AZ191 | 1594092-37-1 | 5mg | 750元 |
1594092-37-1, DYRK1B抑制剂(AZ191) 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- C24H27N7O
- AZ 191,DYRK1B抑制剂
- N-(2-甲氧基-4-(4-甲基哌嗪-1-基)苯基)-4-(1-甲基-1H-吡咯并[2,3-C]吡啶-3-基)嘧啶-2-胺
- 化合物AZ191
- DYRK1B抑制剂(AZ191)
- 1594092-37-1
- Inhibitor,AZ-191,Dual specificity tyrosine regulated kinase,AZ191,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,AZ 191,DYRK
- 2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-
- N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
- CS-1824
- AZ-191;AZ 191
- AZ191
- [2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine
- N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine, AZ191