4E1RCAT
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- CAS号:
- 328998-25-0
- 英文名:
- 4E1RCat
- 英文别名:
- 4E1RCat;CS-1228;inhibit,Inhibitor,4E-1rcat,4E1rcat,Eukaryotic Initiation Factor (eIF),Autophagy;4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid;4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid;4-[2,3-Dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]benzoic acid;Benzoic acid, 4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]Methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]-;4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
- 中文名:
- 4E1RCAT
- 中文别名:
- 4-[2,3-二氢-3-[[5-(4-硝基苯基)-2-呋喃基]亚甲基]-2-氧代-5-苯基-1H-吡咯-1-基]苯甲酸
- CBNumber:
- CB52535655
- 分子式:
- C28H18N2O6
- 分子量:
- 478.45
- MOL File:
- 328998-25-0.mol
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4E1RCAT化学性质
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沸点:
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764.8±60.0 °C(Predicted)
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密度:
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1.423±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥5mg/mL
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形态:
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powder
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酸度系数(pKa):
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4.23±0.10(Predicted)
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颜色:
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brown to dark brown
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4E1RCAT性质、用途与生产工艺
4E1RCat 是一种eIF4E:eIF4G和eIF4E:4E-BP1相互作用的双重抑制剂,以IC50为3.2μM来抑制eIF4G 结合到eIF4E.
IC50: ∼4 μM (eIF4E/eIF4G)
4E1RCat is an inhibitor of eIF4E:eIF4GI interaction, with an IC
50
an of ∼4 μM. 4E1RCat binding to eIF4E also interferes with eIF4G and 4E-BP binding. 4E1RCat inhibits ribosome recruitment to mRNA in a cap-dependent manner. 4E1RCat blocks the capped mRNA translation, and the translation is activated by CDK1/CYCB1. Nearly all new protein synthesis in both mitosis and interphase is cap-dependent and -sensitive to 4E1RCat treatment, in HeLa and U2OS cells.
4E1RCat (15 mg/kg, i.p.) affacts chemosensitivity of Pten
+/-
Eμ-Myc tumors in mice. 4E1RCat (15 mg/kg, i.p.) sensitizes Pten
+/-
Eμ-Myc and Tsc2
+/-
Eμ-Myc lymphomas to the cytotoxic effects of doxorubicin (Dxr), and 4E1RCat targets translation in mice.
4E1RCAT
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-14427 | 4E1RCat | | 1 mg | 363元 |
| 2024/08/19 | HY-14427 | 4E1RCAT
4E1RCat | 328998-25-0 | 5mg | 800元 |
328998-25-0, 4E1RCAT 相关搜索:
- Inhibitors
- 药靶配体
- 医药
- 抑制剂
- 小分子抑制剂
- 小分子抑制剂，天然产物
- 4-[2,3-二氢-3-[[5-(4-硝基苯基)-2-呋喃基]亚甲基]-2-氧代-5-苯基-1H-吡咯-1-基]苯甲酸
- 328998-25-0
- 4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid
- inhibit,Inhibitor,4E-1rcat,4E1rcat,Eukaryotic Initiation Factor (eIF),Autophagy
- CS-1228
- 4-[2,3-Dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]benzoic acid
- 4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid
- 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
- Benzoic acid, 4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]Methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]-
- 4E1RCat