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4E1RCat

4E1RCat Structure
4E1RCat structure
CAS No.
328998-25-0
Chemical Name:
4E1RCat
Synonyms
4E1RCat;CS-1228;inhibit,Inhibitor,4E-1rcat,4E1rcat,Eukaryotic Initiation Factor (eIF),Autophagy;4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid;4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid;4-[2,3-Dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]benzoic acid;Benzoic acid, 4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]Methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]-;4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
CBNumber:
CB52535655
Molecular Formula:
C28H18N2O6
Molecular Weight:
478.45
MDL Number:
MFCD01931282
MOL File:
328998-25-0.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:15
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4E1RCat Properties

Boiling point 764.8±60.0 °C(Predicted)
Density 1.423±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥5mg/mL
form powder
pka 4.23±0.10(Predicted)
color brown to dark brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

4E1RCat price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0197 4E1RCat ≥97% (HPLC) 328998-25-0 5mg $158 2024-03-01 Buy
Sigma-Aldrich SML0197 4E1RCat ≥97% (HPLC) 328998-25-0 25mg $631 2024-03-01 Buy
Cayman Chemical 18399 4E1RCat ≥98% 328998-25-0 1mg $37 2024-03-01 Buy
Cayman Chemical 18399 4E1RCat ≥98% 328998-25-0 5mg $108 2024-03-01 Buy
Cayman Chemical 18399 4E1RCat ≥98% 328998-25-0 10mg $161 2024-03-01 Buy
Product number Packaging Price Buy
SML0197 5mg $158 Buy
SML0197 25mg $631 Buy
18399 1mg $37 Buy
18399 5mg $108 Buy
18399 10mg $161 Buy

4E1RCat Chemical Properties,Uses,Production

Description

4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions. It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 μM. 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage.

Uses

4E1RCat was used to inhibit new protein synthesis in transformed primary chicken embryo fibroblasts.

Biochem/physiol Actions

4E1RCat ilnhibits the eIF4F translation initiation complex by binding to IF4E b and inhibiting the interaction between IF4E:eIF4G (IC50 = 3.2 μM). In in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc.

4E1RCat Preparation Products And Raw materials

Raw materials

Preparation Products

4E1RCat Suppliers

Global( 77)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shenzhen Shengda Pharma Limited 		755-85269922 +8613424394241 sales@shengdapharm.com CHINA 310 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Shenzhen Shengda Pharma Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58

View Lastest Price from 4E1RCat manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid pictures 2020-01-02 4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid
328998-25-0
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co

4E1RCat Spectrum

4E1RCat(328998-25-0)1HNMR

328998-25-0(4E1RCat)Related Search:

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PLX4032

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4E1RCat Benzoic acid, 4-[2,3-dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]Methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]- 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid 4-[(3E)-3-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenylpyrrol-1-yl]benzoic acid 4-[2,3-Dihydro-3-[[5-(4-nitrophenyl)-2-furanyl]methylene]-2-oxo-5-phenyl-1H-pyrrol-1-yl]benzoic acid CS-1228 inhibit,Inhibitor,4E-1rcat,4E1rcat,Eukaryotic Initiation Factor (eIF),Autophagy 4-(3-((5-(4-Nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid 328998-25-0 Inhibitors