(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐
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- CAS号:
- 1222781-70-5
- 英文名:
- ML 133 Hydrochloride
- 英文别名:
- ML133 HCl;ML 133 Hydrochloride;CID 781301 hydrochloride;VU0404943-1 hydrchloride;SID 85281105 hydrochloride;ML 133 Hydrochloride USP/EP/BP;(4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride;N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride;N-[(4-METHOXYPHENYL)METHYL]-1-NAPHTHALENEMETHANAMINE HYDROCHLORIDE;(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride
- 中文名:
- (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐
- 中文别名:
- ML133盐酸盐;(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐;N-[(4-甲氧基苯基)甲基]-1-萘甲胺盐酸盐;N-(4-甲氧基苄基)-1-(萘-1-基)甲胺盐酸盐;ML133 HCL (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐;中文名:?(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐英文名:?N-(4-METHOXYBENZYL)-1-(NAPHTHALEN-1-YL)METHANAMINE HYDROCHLORIDECAS号:1222781-70-5
- CBNumber:
- CB62653895
- 分子式:
- C19H20ClNO
- 分子量:
- 313.83
- MOL File:
- 1222781-70-5.mol
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(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐化学性质
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熔点:
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193-195°C
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥10mg/mL
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形态:
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powder
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颜色:
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white to tan
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(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐性质、用途与生产工艺
ML133 HCl是一种选择性钾离子通道抑制剂,作用于K
ir2.1, IC50为1.8 μM (pH 7.4)和290 nM (pH 8.5),对K
ir1.1没有作用效果,对K
ir4.1和K
ir7.1具有微弱的作用活性。
The ratio of total concentration of extracellular ML133 versus intracellular ML133 is 1:0.13 at pH 6.5, 1:9.09 at pH 8.5. ML133 is clean against 3A4 and 2C9 (IC50 >30 μM), displays moderate inhibition of 1A2 (IC50 = 3.3 μM) but proves to be a potent inhibitor of 2D6 (IC50 = 0.13 μM) in CYP450 assay. ML133 is highly protein bound (>99%) in both human and rat and also displays high intrinsic clearance in both species. ML133 (10 μM) is not displaced by K
+ influx from the wild-type K
ir2.1 in HEK 293 cells. M1 and/or M2 transmembrane domains contain the critical molecular determinant for ML133 inhibition of K
ir2.1, especially D172 and I176.
IC50: 1.8 μM (K
ir
2 at pH 7.4), 290 nM (K
ir
2 at pH 8.5).
(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-100230A | (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 ML133 hydrochloride | 1222781-70-5 | 5mg | 500元 |
2024/08/19 | HY-100230A | (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 ML133 hydrochloride | 1222781-70-5 | 10mM * 1mLin DMSO | 550元 |
(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐
生产厂家
1222781-70-5, (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Aromatics
- Amines
- Inhibitors
- 药靶配体
- 小分子抑制剂,天然产物
- 膜转运
- 离子通道
- 膜转运/离子通道
- C19H19NOHCl
- 中文名:?(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐英文名:?N-(4-METHOXYBENZYL)-1-(NAPHTHALEN-1-YL)METHANAMINE HYDROCHLORIDECAS号:1222781-70-5
- N-(4-甲氧基苄基)-1-(萘-1-基)甲胺盐酸盐
- ML133盐酸盐
- (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐
- N-[(4-甲氧基苯基)甲基]-1-萘甲胺盐酸盐
- ML133 HCL (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐
- 1222781-70-5
- Potassium Channel,KcsA,Inhibitor,inhibit,ML 133,ML-133 hydrochloride,ML133 hydrochloride,ML133,ML-133
- ML 133 Hydrochloride USP/EP/BP
- N-[(4-METHOXYPHENYL)METHYL]-1-NAPHTHALENEMETHANAMINE HYDROCHLORIDE
- (4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride
- VU0404943-1 hydrchloride
- SID 85281105 hydrochloride
- N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride
- 1-Naphthalenemethanamine, N-[(4-methoxyphenyl)methyl]-, hydrochloride (1:1)
- ML133 HCl
- N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride (1:1)
- CID 781301 hydrochloride
- 1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride
- ML 133 Hydrochloride
- (4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride