金合欢 (Acacia farnesiana (Linn.) Willd.) (Mimosa) 豆科。灌木,高2-4米;枝具刺,刺长可达1-2厘米。二回羽状复叶,羽片4-8对,每羽片具小叶10-20对,小叶片线状长椭圆形。头状花序腋生,直径1.5厘米,常多个簇生。荚果圆柱形,长3-7厘米,直径8-15毫米。种子多数,黑色。 花极香,供提取香精。 刺灌术或小乔木,二回羽状复叶,头状花序簇生于叶腋,盛开时,好像金色的绒球一般。
Acacetin (5,7-Dihydroxy-4'-methoxyflavone; 10-200 μM; 24 hours) decreases cell viabilities in a dose-dependent manner. Acacetin has little effect on human normal glial cell line HEB and non-tumorigenic epithelial cell line MCF-10A. Acacetin (50-150 μM; 24 hours) causes G2/M cell cycle arrest and induces apoptosis and autophagy. Acacetin (50-150 μM; 24 hours) leads to decreases in levels of PI3Kγ-p110, p-AKT, p-mTOR, p-p70S6K, and p-ULK in a dose-dependent manner.
Cell Viability Assay
Cell Cycle Analysis
Apoptosis Analysis
Cell Autophagy Assay
Western Blot Analysis
Acacetin (5,7-Dihydroxy-4'-methoxyflavone; 5, 20 mg/kg/day; orally; for 3 days) significantly suppresses microglial activation in an LPS-induced neuroinflammation mouse model. Acacetin (25 mg/kg/day; orally; for 3 days) reduces neuronal cell death in an animal model of ischemia. Acacetin (1.8-56.2 mg/kg/day; ip; single dose) decreases visceral and inflammatory nociception and prevented the formalin-induced oedema.