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(8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid Produkt Beschreibung

Doxorubicin hydrochloride Struktur
25316-40-9
CAS-Nr.
25316-40-9
Bezeichnung:
(8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
Englisch Name:
Doxorubicin hydrochloride
Synonyma:
DOX;ADR;Caely;fi6804;CAELYX;FI 106;DOX HCl;Lipodox;ADRIACIN;Ardriamycin
CBNumber:
CB0110633
Summenformel:
C27H30ClNO11
Molgewicht:
579.98
MOL-Datei:
25316-40-9.mol

(8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid Eigenschaften

Schmelzpunkt:
216 °C (dec.)(lit.)
alpha 
D20 +248±2° (c = 0.1 in methanol)
storage temp. 
2-8°C
Löslichkeit
H2O: 10 mg/mL, clear, red-orange
pka
pKa 8.25±0.60 (Uncertain);8.43±0.70 (Uncertain);11.9±0.4 (Uncertain);12.95±0.1 (Uncertain);13.8±0.70 (Uncertain)
Aggregatzustand
solid
Farbe
orange to dark red
Wasserlöslichkeit
Soluble in water.
maximale Wellenlänge (λmax)
497nm(H2O)(lit.)
Merck 
14,3439
BRN 
4229251
InChIKey
MWWSFMDVAYGXBV-RUELKSSGSA-N
CAS Datenbank
25316-40-9(CAS DataBase Reference)
EPA chemische Informationen
5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-. alpha.-L-lyxo-hexopyranosyl) oxy]-7,8,9,10-tetrahydro- 6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxy-, hydrochloride, (8S,10S)-(25316-40-9)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,T+,Xi
R-Sätze: 45-22-40-26/27/28-36/38
S-Sätze: 53-45-36/37/39-22-7/9
WGK Germany  3
RTECS-Nr. QI9295900
10-21
HS Code  29419090
Toxizität LD50 i.v. in mice: 21.1 mg/kg (Bertazzoli, 1970)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H350 Kann Krebs verursachen. Karzinogenität Kategorie 1A Achtung
H351 Kann vermutlich Krebs verursachen. Karzinogenität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H373 Kann die Organe schädigen bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

(8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R45:Kann Krebs erzeugen.
R22:Gesundheitsschädlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
S7/9:Behälter dicht geschlossen an einem gut gelüfteten Ort aufbewahren.

Chemische Eigenschaften

Orange-Red Crystalline Solid

Chemische Eigenschaften

Adriamycin is an orange to red cake-like or needle-like crystalline solid.

Verwenden

Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.

Verwenden

Antibacterial;DNA intercalant

Verwenden

Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.

Verwenden

Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.[Cayman Chemical]

Verwenden

Used as an antineoplastic

Trademarks

Adriamycin (Pharmacia & Upjohn); Doxil (ALZA); Rubex (Bristol-Myers Squibb).

Allgemeine Beschreibung

Orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9.

Allgemeine Beschreibung

Doxorubicin is available as both the conventional dosageform and a liposomal preparation, both of which are administeredby infusion. Doxorubicin HCl powder is available in10-, 20-, 50-, and 150-mg vials and is widely used in treatingvarious cancers, including leukemias, soft and bone tissuesarcomas, Wilms tumor, neuroblastoma, small cell lungcancer, and ovarian and testicular cancer.

Air & Water Reaktionen

Water soluble.

Reaktivität anzeigen

Amines, like Doxorubicin hydrochloride, are weak chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Brandgefahr

Doxorubicin hydrochloride is probably combustible.

Biologische Aktivität

Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.

mögliche Exposition

An antibiotic product from streptomyces, used as anticancer drug

Veterinary Drugs and Treatments

Doxorubicin is perhaps the most widely used antineoplastic agent at present in small animal medicine. It may be useful in the treatment of a variety of lymphomas, carcinomas, leukemias, and sarcomas in both the dog and cat, either alone or in combination protocols. Refer to the Dosage references or the Protocols found in the appendix for more information.

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Inkompatibilitäten

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides

Waste disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

(8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 419)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales01@yibaibiotech.com CHINA 410 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21726 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 210 58

25316-40-9((8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid)Verwandte Suche:


  • Doxorubicin-13C-d3 HCl
  • 10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-12-naphthacenedione
  • 8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-xy)-hydroc
  • admhydrochloride
  • Ardriamycin
  • fi6804
  • DOX
  • Adriamycin(R) hydrochloride, DOX, Hydroxydaunorubicin hydrochloride
  • Doxorubicin solution hydrochloride
  • 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
  • (1S,3S)-3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-(3-amino-2,3,6-tridesoxy-alpha-L-lyxo-hexopyranosid) hydrochloride
  • Adriblastin hydrochloride
  • Doxorrubicin Hydrochloride
  • 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedionehydrochloride
  • Doxorubicin hydrochloride,Adriamycin hydrochloride, DOX, Hydroxydaunorubicin hydrochloride
  • Doxorubicin Hydrochloride (50 mg)
  • Doxorubicin hydrochl
  • Doxorubicin hydrochloride((AdriaMycin)
  • Doxorubicin Hydrochloride, USP
  • Doxorubicin HCl/AdriaMycin
  • (8S,10S)-8-acetyl-10-{[(2R,4S,5S,6S)-4-aMino-5-hydroxy-6-Methyloxan-2-yl]oxy}-6,8,11-trihydroxy-1-Methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione
  • (8S,10S)-10-[(3-AMino-2,3,6-trideoxy-α-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-Methoxy-5,12-naphthacenedione Hydrochloride
  • Doxorubicin HCl API
  • AdriaMycin(Doxorubicin)
  • DOXORUBICIN LIPOSOMAL
  • Doxorubicin (Adriamycin) HCl
  • Doxorubicin hydrochloride 25316-40-9
  • ADRIACIN
  • ADRIBLASTINA
  • ADRIBLASTINA HYDROCHLORIDE
  • ADRIAMYCIN HCL
  • ADRIAMYCIN HYDROCHLORIDE
  • (8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
  • 14-HYDROXYDAUNOMYCIN HCL
  • 14-HYDROXYDAUNOMYCIN HYDROCHLORIDE
  • CAELYX
  • DOX HYDROCHLORIDE
  • DOXORUBICIN HCL
  • DOXORUBICIN HYDROCHLORIDE
  • HYDROXYDAUNORUBICIN HYDROCHLORIDE
  • (8s-cis)-hlorid
  • DOXORUBICIN HYDROCHLORIDE, FOR FLUORESCE NCE
  • DOXORUBICIN HYDROCHLORIDE WITH EXTENDER AND PRESERVA
  • DOXORUBICIN HYDROCHLORIDE (ADRIAMYCIN HC L) \ APOPTOSIS INDUCER
  • DOXORUBICIN HYDROCHLORIDE SOLUTION 2 MG/
  • DOXORUBICIN HYDROCHLORIDE 98+%
  • DOXORUBICIN HCL/ DOXORUBICIN HYDROCHLORIDE
  • DoxorubicinHcl,Usp28
  • (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-a-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
  • Caely
  • Adriamycin HCl Solution
  • 5,12-Naphthacenedione, 10-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
  • DOXORUBICINHCL(FDA)
  • 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
  • 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
  • ADR
  • Adriamycin, hydrochloride (8CI)
  • Adriblastina RD
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