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3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol Produkt Beschreibung

DL-α-Tocopherol Struktur
10191-41-0
CAS-Nr.
10191-41-0
Bezeichnung:
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol
Englisch Name:
DL-α-Tocopherol
Synonyma:
3,;8-(4;ecyl)-;ephanyl;TGF-β-3;hTGF-β3;A-TOCOPHEROL;DL-VITAMIN E;4-BroMo-2-(5;FIIN-​
CBNumber:
CB5275357
Summenformel:
C29H50O2
Molgewicht:
430.71
MOL-Datei:
10191-41-0.mol

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol Eigenschaften

Schmelzpunkt:
2-4°C
Siedepunkt:
200-220°C 0,1mm
alpha 
[α]D20 - 0.02 - +0.02゜ (neat)
Dichte
0.950 g/mL at 20 °C(lit.)
Brechungsindex
n20/D 1.506
Flammpunkt:
240°C
storage temp. 
2-8°C
Löslichkeit
H2O: insoluble
Aggregatzustand
Pale yellow oil
pka
11.40±0.40(Predicted)
Wasserlöslichkeit
Miscible with chloroform, vegetable oils, ether, acetone and alcohol. Immiscible with water.
Sensitive 
Light Sensitive
Merck 
14,9495
BRN 
94012
InChIKey
GVJHHUAWPYXKBD-IEOSBIPESA-N
CAS Datenbank
10191-41-0(CAS DataBase Reference)
EPA chemische Informationen
2H-1-Benzopyran- 6-ol, 3,4-dihydro-2,5,7,8-tetramethyl- 2-(4,8,12-trimethyltridecyl)- (10191-41-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi,T,F
R-Sätze: 36/37/38-39/23/24/25-23/24/25-11
S-Sätze: 26-37/39-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1
RTECS-Nr. GA8746000
8-10-23
TSCA  Yes
HS Code  29362800
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P370+P378 Bei Brand: zum Löschen verwenden.
P403+P235 An einem gut belüfteten Ort aufbewahren. Kühl halten.

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Chemische Eigenschaften

Alpha tocopherol is a natural product. The PhEur 6.0 describes alpha-tocopherol as a clear, colorless or yellowish-brown, viscous, oily liquid.

Chemische Eigenschaften

1mg = 1.1 IU

Verwenden

An antioxidant that protects cell membrane lipids from oxidative damage

Vorbereitung Methode

Naturally occurring tocopherols are obtained by the extraction or molecular distillation of steam distillates of vegetable oils; for example, alpha tocopherol occurs in concentrations of 0.1–0.3% in corn, rapeseed, soybean, sunflower, and wheat germ oils.Beta and gamma tocopherol are usually found in natural sources along with alpha tocopherol. Racemic synthetic tocopherols may be prepared by the condensation of the appropriate methylated hydroquinone with racemic isophytol.

Pharmazeutische Anwendungen

Alpha tocopherol is primarily recognized as a source of vitamin E, and the commercially available materials and specifications reflect this purpose. While alpha tocopherol also exhibits antioxidant properties, the beta, delta, and gamma tocopherols are considered to be more effective as antioxidants.
Alpha-tocopherol is a highly lipophilic compound, and is an excellent solvent for many poorly soluble drugs.Of widespread regulatory acceptability, tocopherols are of value in oil- or fat-based pharmaceutical products and are normally used in the concentration range 0.001–0.05% v/v. There is frequently an optimum concentration; thus the autoxidation of linoleic acid and methyl linolenate is reduced at low concentrations of alpha tocopherol, and is accelerated by higher concentrations. Antioxidant effectiveness can be increased by the addition of oil-soluble synergists such as lecithin and ascorbyl palmitate.
Alpha tocopherol may be used as an efficient plasticizer. It has been used in the development of deformable liposomes as topical formulations.
d-Alpha-tocopherol has also been used as a non-ionic surfactant in oral and injectable formulations.

Sicherheit(Safety)

Tocopherols (vitamin E) occur in many food substances that are consumed as part of the normal diet. The daily nutritional requirement has not been clearly defined but is estimated to be 3.0–20.0 mg. Absorption from the gastrointestinal tract is dependent upon normal pancreatic function and the presence of bile. Tocopherols are widely distributed throughout the body, with some ingested tocopherol metabolized in the liver; excretion of metabolites is via the urine or bile. Individuals with vitamin E deficiency are usually treated by oral administration of tocopherols, although intramuscular and intravenous administration may sometimes be used.
Tocopherols are well tolerated, although excessive oral intake may cause headache, fatigue, weakness, digestive disturbance, and nausea. Prolonged and intensive skin contact may lead to erythema and contact dermatitis.
The use of tocopherols as antioxidants in pharmaceuticals and food products is unlikely to pose any hazard to human health since the daily intake from such uses is small compared with the intake of naturally occurring tocopherols in the diet.
The WHO has set an acceptable daily intake of tocopherol used as an antioxidant at 0.15–2.0 mg/kg body-weight.

Lager

Tocopherols are oxidized slowly by atmospheric oxygen and rapidly by ferric and silver salts. Oxidation products include tocopheroxide, tocopherylquinone, and tocopherylhydroquinone, as well as dimers and trimers. Tocopherol esters are more stable to oxidation than the free tocopherols but are in consequence less effective antioxidants.
Tocopherols should be stored under an inert gas, in an airtight container in a cool, dry place and protected from light.

läuterung methode

Dissolve dl--tocopherol in anhydrous MeOH (15mL/g) cool to -6o for 1hour, then chill in a Dry-ice/acetone bath; crystallisation is induced by scratching with a glass rod. The dl--acetate [52225-20-4] (see DL-vitamin E actetate below) is a viscous yellow liquid with m -7o, b 184o/0.01mm, 224o/0.3mm, d 4 20 0.953, n D 20 1.496. It is used as a standard for Vitamin E activity where the unit of activity is attained with 1mg of pure dl--acetate. [Friedrich “Vitamins” Water de Guyter Publ, Berlin 1988, Beilstein 17/4 V 168.]

Inkompatibilitäten

Tocopherols are incompatible with peroxides and metal ions, especially iron, copper, and silver. Tocopherols may be absorbed into plastic.

Regulatory Status

GRAS listed. Accepted in Europe as a food additive. Included in the FDA Inactive Ingredients Database (IV injections, powder, lyophilized powder for liposomal suspension; oral capsules, tablets, and topical preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.

3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 222)Lieferanten
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Henan DaKen Chemical CO.,LTD.
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13540674322 15828370308,QQ:2879822141
028-89481236 service@2hpharm.com CHINA 121 55
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0371-55170693
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+86-021-57951555
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10191-41-0(3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol)Verwandte Suche:


  • 6 LC, cleaved (E942)
  • 维生素E杂质Ⅰ(α-生育酚)
  • (+/-)-α-Tocopherol, Synthetic
  • 4-Dimethoxy-phenyl)-(toluene-4-sulfonyl)-amino]-acetic acid
  • All-rac-alfa-Tocopherol EPImpurity A
  • All-rac-alfa-Tocopherol EPImpurity B
  • All-rac-alfa-TocopherolEP impurity C
  • (±)-a-Tocopherol, liquid
  • All-rac-α-Tocopherol
  • 4, phosphorylated (S1027) (ITGA4, Integrin alpha-4, CD49 Antigen-like Family Member D, Integrin alpha-IV, VLA-4 Subunit alpha, CD49d, CD49D)
  • Ertapenem side chain 3
  • 5 LC, cleaved (E895)
  • ALL-RAC-ALPHA-TOCOPHEROL
  • (+/-)-ALPHA-TOCOPHEROL
  • (+/-)-ALPHA-TOCOFEROL
  • ALPHA-TOCOPHEROLUM
  • ALPHA-DL-TOCOPHEROL
  • 5,7,8-TRIMETHYLTOCOL
  • A-TOCOPHEROL
  • IRGANOX E 201
  • DL-TOCOPHEROL
  • DL-VITAMIN E
  • DL-VITAMIN E ALCOHOL
  • DL-PROFECUNDIN
  • DL-PHYTOGERMINE
  • DL-ALL-RAC-ALPHA-TOCOPHEROL
  • DL-ALPHA-TOCOPHEROL
  • DL-ALPHA TOCOPHERYL ACETATE 500
  • D, L-A-TOCOPHEROL
  • DL-5,7,8-TRIMETHYLTOCOL
  • DL-2,5,7,8-TETRAMETHYL-2-(4,8,12-TRIMETHYLTRIDECYL)-6-CHROMANOL
  • RAC-ALPHA-TOCOPHEROL
  • TOCOPHEROL, ALPHA-DL-
  • VITAMIN E (DL-FORM)
  • 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromano
  • ecyl)-
  • ephanyl
  • DL-all-rac-α-Tocopherol
  • DL-ALPHA-TOCOPHEROL, PH EUR
  • VITAMIN E (MIXED TOCOPHEROL) NATURAL 50%
  • VITAMIN E OIL, 96-102% USP
  • ALPHA TOCOPHEROL (VITAMIN E ALCOHOL) USP(CRM STANDARD)
  • (±)-α-Tocopherol,DL-all-rac-α-Tocopherol, VitaminE
  • Vitamin E 100mg [10191-41-0]
  • Alpha Tocopherol (250 mg) (Vitamin E Alcohol)
  • (§1)-alpha-Tocopherol, synthetic, 95%
  • VitaMin E Alcohol
  • 1-benzyl-5-chloro-1
  • 4-tetrahydro-1
  • 5-TriMethyl-1H-pyrazol-4-yl)ethanol
  • 2-(1-Fluoronaphthalen-4-yl)-4
  • 2-(2-Isopropylphenyl)-4
  • 2-(3-Fluoro-4-Methoxyphenyl)4
  • 2-benzyl-5-chloro-1
  • 4-tetrahydro-2
  • 2-Cyclopropyl-4
  • 2-dioxaborinan-2-yl)pyridine
  • 2-dioxaborinan-2-yl)benzonitrile
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