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Coenzym Q-10 Produkt Beschreibung

Ubidecarenone Struktur
303-98-0
CAS-Nr.
303-98-0
Bezeichnung:
Coenzym Q-10
Englisch Name:
Ubidecarenone
Synonyma:
Q-10;Coen;Q-Gel;COQ10;Ensorb;AquaQ10;Cudesan;Coenz10;Kudesan;CoQ10-d6
CBNumber:
CB0121840
Summenformel:
C59H90O4
Molgewicht:
863.34
MOL-Datei:
303-98-0.mol

Coenzym Q-10 Eigenschaften

Schmelzpunkt:
49-51 °C
Siedepunkt:
715.32°C (rough estimate)
Dichte
0.9145 (rough estimate)
Brechungsindex
1.4760 (estimate)
storage temp. 
-20°C
Löslichkeit
Soluble in chloroform.
Aggregatzustand
neat
Sensitive 
Light Sensitive
Merck 
14,9843
BRN 
1900141
Stabilität:
Stable, but may be light or heat sensitive. Store in the dark at -20 C. Incompatible with strong oxidizing agents.
InChIKey
ACTIUHUUMQJHFO-DQXDOXBUSA-N
CAS Datenbank
303-98-0(CAS DataBase Reference)
EPA chemische Informationen
Ubidecarenone (303-98-0)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 22-24/25-26
WGK Germany  3
RTECS-Nr. DK3900000
8-10
TSCA  Yes
HS Code  29146990
Toxizität LD50 intramuscular in mouse: > 500mg/kg

Coenzym Q-10 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

Yellow-Orange Crystalline Powder

Originator

Neuquinon,Eisai,Japan,1974

Occurrence

Coenzyme Q10 is found in dietary sources.

Verwenden

Antibacterial and antioxidant for preventing and treating cancer.

Verwenden

Coenzyme Q10 (CoQ10) is a naturally occurring quinone found throughout the body in cell membranes, primarily in mitochondrial membranes, with highest concentrations in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands. It is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, CoQ10 acts as an antioxidant, preventing the formation of reactive oxygen species. CoQ10 deficiencies have been associated with heart failure, hypertension, parkinsonism, mitochondrial encephalomyopathies, and other chronic diseases.[Cayman Chemical]

Verwenden

Ubidecarenone is also known as coenzyme Q10 it is a powerful antioxidant that is naturally found in the cells. It acts as a free radical neutraliser.

Definition

Found in animal organs and yeast. Active in the citric acid cycle in carbohydrate metabolism. The n in the formula varies according to the source.

Definition

ubiquinone: Any of a group of relatedquinone-derived compoundsthat serve as electron carriers in theelectron transport chain reactionsof cellular respiration. Coenzyme Qmolecules have side chains of differentlengths in different types of organismsbut function in similar ways.

Manufacturing Process

A small fermentation tank (5,000 parts by volume capacity) was charged with 3,000 parts by volume of a culture medium (pH 6.0) comprising 3% glucose, 1% polypepton, 0.5% yeast extract and 0.5% malt extract. The medium was sterilized by heating in a conventional manner and cooled. This medium was inoculated with 150 parts by volume of a pre-culture of Sporidiobolus ruinenii CBS-5001, which had been prepared by growing the same strain on a medium of the same composition as above at 28°C for one day. The inoculated medium was incubated at 28°C and under agitation at 800 rpm with sparging at a rate of 3,000 parts by volume per minute for 24 hours. During this fermentation period, the medium was maintained at pH 6.0 with ammonia and sulfuric acid.
The resultant fermentation broth was centrifuged to harvest the microbial cells, and they were washed with water and centrifuged a second time, whereupon a living cell paste was obtained. (There was obtained an amount of cells equivalent to 54 parts on a dry basis, which contained 920 μg of ubiquinone-10 per gram of dry cells.)
The moist cells were suspended in 750 parts of volume of ethanol and extracted by warming at 60°C for 1 hour. A total of 3 extractions were carried out in a similar manner and the extracts were pooled, diluted with water and further extracted three times with 1,000 parts of volume portions of n_x0002_hexane. The n-hexane layer was concentrated to dryness under reduced pressure to recover 4.12 parts of a yellow oil. This oily residue was dissolved in 6 parts by volume of benzene and passed through a column (500 parts by volume capacity) packed with Floridil (100 to 200 meshes). Elution was carried out using benzene and the eluate was collected in 10 parts by volume fractions. Each fraction was analyzed by thin-layer chromatography and color reaction and the fractions rich in ubiquinone-10 were pooled and concentrated under reduced pressure. By this procedure was obtained 0.562 part of a yellow oil. This product was dissolved in 5 parts by volume of chloroform, coated onto a thin layer plate of silica gel GF254 (silica gel with calcium sulfate) and developed with benzene. The fractions corresponding to ubiquinone-10 were extracted, whereby 0.054 part of a yellow oil was obtained. This oil was dissolved in 10 parts by volume of ethanol and allowed to cool, whereupon 0.029 part of yellow crystals of ubiquinone-10 were obtained, its melting point 48° to 50°C.
There are also synthetic routes to the ubiquinones as described in US Patents 3,068,295; 3,896,153 and 4,062,879.

Therapeutic Function

UBIDECARENONE

Biologische Aktivität

Component of the mitochondrial transporter chain that behaves as a powerful antioxidant. Displays neuroprotective activity.

läuterung methode

Purify it by recrystallisation from EtOH, EtOH/Me2CO or Et2O/EtOH and by chromatography on silica gel using isoPrOH/Et2O (3:1) to give orange crystals. It has max 270nm ( 15,170) in pet ether. [Terao et al. J Org Chem 44 868 1979, NMR and MS: Naruta et al. J Org Chem 45 4097 1980, IR: Lester et al. Biochem Biophys Acta 42 1278 1959, NMR: Planta et al. Helv Chim Acta 42 1278 1959; Morton Biochemical Spectroscopy (Adam Hilger, London, 1975) p 491].

Coenzym Q-10 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Coenzym Q-10 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 620)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
Hebei Henghe Import and Export Trading Co. LTD
18032916000 +8618032935937
demi@hbtycoon.com CHINA 453 58
HONG KONG IPURE BIOLOGY CO.,LIMITED
18062405514 86 18062405514
ada@ipurechemical.com CHINA 3475 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
18802962783
rebecca@tgybio.com CHINA 1218 58
Baoji Guokang Healthchem co.,ltd
09178656283
cngksw@aliyun.com CHINA 9483 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
Hebei Yime New Material Technology Co., Ltd.
031188129959
admin@china-yime.com CHINA 238 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58

303-98-0(Coenzym Q-10)Verwandte Suche:


  • coenzyme Q10 synthetic
  • Coenzyme Q10 (Water soluble)
  • CoQ10 Ubidecarenone
  • Coenzyme Q10 standard
  • COENZYM Q10 SYNTHETIC: 99.5%
  • CoenzymeA/Q0/Q10A85-61-0/Q10
  • CoenzymeQ10Ubidecarenone
  • CoenzymeQ10Usp27Ep5
  • CoenzymeQ10&Int.
  • Coenzyme Q10 (Fermentation)
  • Coenzyme Q10 (Synthesize)
  • Water soluble Coenzyme Q10 (Fermentation)10%/20%
  • Ubidecarenone=Ubiquinone50
  • Ubiquinone 10 (Coenzyme Q10)
  • Ubichinon-50
  • Vitamin-Q10
  • 2,5-Cyclohexadiene-1,4-dione, 2-(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl-5,6-dimethoxy-3-methyl-
  • UBIDECARENONE,NF
  • RAW MATERIAL COENZYME Q10 POWDER(COQ10)
  • COENZYME Q10(Natural)(P)
  • COENZYMEQ10(UBIQUINONE-10)
  • Ubidecarenone (Coenzyme Q10)
  • Water soluble Coenzyme Q10
  • COENZYME Q1O extrapure
  • NSC 140865
  • PureSorb Q 40
  • Q-Gel
  • Q-Gel 100
  • Unispheres Q 10
  • (all-E)-2-(3,7,11,15,19,23,27,31,35,39-DecaMethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-(diMethoxy-d6)-3-Methyl-2,5-cyclohexadiene-1,4-dione
  • Bio-Quinone Q10-d6
  • CoQ10-d6
  • CosMesoMe Q 10-d6
  • Ensorb-d6
  • Kaneka Q10-d6
  • CoenzyMe Q10 10%/20%/40% Food Grade
  • Ubidecarenone Ubiquinone 10
  • 2-(3,7,11,15,19,23,27,31,35,39-DECAMETHYL-TETRACONTA-2,6,10,14,18,22,26,30,34,38-DECAENYL)-5,6-DIMETHOXY-3-METHYL-[1,4]BENZOQUINONE
  • CoenzyMe R10
  • MICROORGANISMBIOMASS
  • CoQ10/Coenzyme Q-10
  • CoenzyMe-Q10-D5
  • AquaQ10
  • Bio-Quinon
  • Cudesan
  • CoenzyMe Q10(exploiting)
  • UBIDECARENONE [5MM]
  • CoenzyMe Q10 NF
  • fermentation coenzyme q10
  • NanoLiposomal UBIQUINONE, NanoLiposomal Coenzyme Q 10
  • Coenzym Q-10
  • LABOTEST-BB LT00244787
  • COQ10
  • COENZYME Q10
  • Q-10
  • Q10 COENZYME
  • UBIDECARENONE
  • UBIQUINONE
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