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3-Methyl-1-phenyl-5-pyrazolon Produkt Beschreibung

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Struktur
89-25-8
CAS-Nr.
89-25-8
Bezeichnung:
3-Methyl-1-phenyl-5-pyrazolon
Englisch Name:
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Synonyma:
PMP;Radicu;NSC-12;-3-one;Radicut;MCI-186;NSC-2629;Adaravone;EDARAVONE;NSC-26139
CBNumber:
CB1287462
Summenformel:
C10H10N2O
Molgewicht:
174.2
MOL-Datei:
89-25-8.mol

3-Methyl-1-phenyl-5-pyrazolon Eigenschaften

Schmelzpunkt:
126-128 °C(lit.)
Siedepunkt:
287 °C265 mm Hg(lit.)
Dichte
1,12 g/cm3
Brechungsindex
1.6300 (estimate)
Flammpunkt:
191°C/17mm
storage temp. 
2-8°C
Löslichkeit
3.30g/l
pka
2.73±0.50(Predicted)
Aggregatzustand
Crystalline Powder
Farbe
Yellow to beige
PH
4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
Wasserlöslichkeit
3 g/L (20 ºC)
Merck 
14,6713
BRN 
609575
InChIKey
QELUYTUMUWHWMC-UHFFFAOYSA-N
CAS Datenbank
89-25-8(CAS DataBase Reference)
NIST chemische Informationen
3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)
EPA chemische Informationen
1-Phenyl-3-methyl-5-pyrazolone (89-25-8)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36
WGK Germany  1
RTECS-Nr. UQ9625000
TSCA  Yes
HS Code  29331990
Giftige Stoffe Daten 89-25-8(Hazardous Substances Data)
Toxizität LD50 orl-rat: 3500 mg/kg LONZA# 08FEB79
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

3-Methyl-1-phenyl-5-pyrazolon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Edaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.

Beschreibung

MCI-186 is a free radical scavenger with diverse protective effects in vivo. Most notably, it reduces damage due to ischemia-reperfusion injury in lung, liver, and brain in animal models of transplant, infection, traumatic brain injury, and stroke. MCI-186 provides these protective effects, at least in part, by reducing reactive oxygen species, inhibiting apoptosis, and blocking nonenzymatic peroxidation and lipoxygenase activity.

Chemische Eigenschaften

Off white to light yellow powder

Originator

Mitsubishi Pharma (Japan)

Verwenden

3-Methyl-1-phenyl-2-pyrazolin-5-one used as reagent for detection of reducing carbohydrates by ESI/MALDI -MS.

Verwenden

Edaravone inhibits the disease activity in rheumatoid arthritis.

Verwenden

antioxidant, lipoxygenase inhibitor

Definition

ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.

Trademarks

Radicut

Allgemeine Beschreibung

A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 μM). Inhibits mitochondrial permeability transition pore.

Hazard

Toxic by ingestion.

Biologische Aktivität

A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.

Biochem/physiol Actions

Product does not compete with ATP.

Sicherheitsprofil

Moderately toxic by ingestion andintraperitoneal routes. An eye irritant. When heated todecomposition it emits toxic fumes of NOx.

läuterung methode

Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]

3-Methyl-1-phenyl-5-pyrazolon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3-Methyl-1-phenyl-5-pyrazolon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 616)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Guangzhou TongYi biochemistry technology Co.,LTD
+8613073028829
mack@tongyon.com China 3000 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15427 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Anhui Royal Chemical Co., Ltd.
+86-025-86655873
marketing@royal-chem.com CHINA 536 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5941 58

89-25-8(3-Methyl-1-phenyl-5-pyrazolon)Verwandte Suche:


  • TIMTEC-BB SBB003801
  • PMP
  • MONOPYRAZOLONE
  • 2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-on
  • 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
  • 3H-Pyrazol-3-one,2,4-dihydro-5-methyl-
  • 3-methyl-1-phenyl-2-pyrazolin-5-on
  • 3-methyl-1-phenyl-5-pyrazolon
  • 3-Methyl-1-phenylpyrazol-5-one
  • 3-Methyl-1-phenylpyrazolin-5-one
  • 5-Pyrazolone, 3-methyl-1-phenyl-
  • Developer Z
  • 3-Methyl-1-pehnyl-2-pyrazolin-5-one
  • 1-phenyl-3-methyl-5-pyrazolone(PMP)
  • Adaravone
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+%
  • 1-Phenyl-3-methyl-1H-4,5-dihydropyrazol-5-one
  • Radicu
  • 3-Methyl-1-phenyl-5-pyrazolido
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
  • N-demethylantipyrine
  • PHENYLMETHYLPYRAZOLON
  • 3-methyl-1-pheny-1-1H-pyrazol-5(4H)-one
  • 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE [NORANTIPYRINE]
  • Radicut
  • Methyl-1-phenyl-2-pyrazolin-5-one, 3-
  • 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
  • 1-Phenyl-3-methyl-2-prazolin-5-one
  • 3-Methyl-1-phenylpyrazolin-5(4H)-one
  • 5-Methyl-2-phenyl-1H-pyrazol-3-one
  • -1,2-dihydropyrazoL
  • MCI-186
  • EDARAVONE
  • C.I. Developer 1
  • AURORA KA-3365
  • 2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one
  • 1-PHENYL-3-METHYL-5-OXO-2-PYRAZOLINE
  • 1-PHENYL-3-METHYL-5-PYRAZALONE
  • 5-METHYL-2-PHENYL-2,4-DIHYDRO-3H-PYRAZOL-3-ONE
  • 5-METHYL-2-PHENYL-2,4-DIHYDRO-PYRAZOL-3-ONE
  • 3-METHYL-1-PHENYL-5-PYRAZOLONE
  • 3-METHYL-1-PHENYL-5-PYROZOLENE
  • 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE
  • 3-METHYL-1-PHENYL-2-PYRAZOLINE-5-ONE
  • AKOS B029819
  • developerz
  • Methylphenylpyrazolone
  • NCI-C03952
  • norantipyrine
  • Norphenazone
  • NSC-12
  • NSC-26139
  • NSC-2629
  • phenylmethylpyrazolone
  • 1-Fenyl-3-methyl-2-pyrazolin-5-on
  • 1-Phenyl-3-methyl-5-pyrazolon
  • 1-Phenyl-3-methylpyrazolone
  • 1-Phenyl-3-methylpyrazolone-5
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