3-Methyl-1-phenyl-5-pyrazolon
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- CAS-Nr.
- 89-25-8
- Bezeichnung:
- 3-Methyl-1-phenyl-5-pyrazolon
- Englisch Name:
- 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
- Synonyma:
- PMP;EDARAVONE;1-Phenyl-3-methyl-5-pyrazolone;5-METHYL-2-PHENYL-2,4-DIHYDRO-3H-PYRAZOL-3-ONE;3-methyl-1-phenyl-1H-pyrazol-5(4H)-one;Norphenazone;3-METHYL-1-PHENYL-5-PYRAZOLONE;3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE;MONOPYRAZOLONE;PHENYLMETHYLPYRAZOLON
- CBNumber:
- CB1287462
- Summenformel:
- C10H10N2O
- Molgewicht:
- 174.2
- MOL-Datei:
- 89-25-8.mol
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3-Methyl-1-phenyl-5-pyrazolon Eigenschaften
- Schmelzpunkt:
- 126-128 °C(lit.)
- Siedepunkt:
- 287 °C265 mm Hg(lit.)
- Dichte
- 1,12 g/cm3
- Dampfdruck
- 0.016Pa at 20℃
- Brechungsindex
- 1.6300 (estimate)
- Flammpunkt:
- 191°C/17mm
- storage temp.
- 2-8°C
- Löslichkeit
- 3.30g/l
- pka
- 2.73±0.50(Predicted)
- Aggregatzustand
- Crystalline Powder
- Farbe
- Yellow to beige
- PH
- 4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
- Wasserlöslichkeit
- 3 g/L (20 ºC)
- Merck
- 14,6713
- BRN
- 609575
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChIKey
- QELUYTUMUWHWMC-UHFFFAOYSA-N
- LogP
- 0.75 at 24℃
- CAS Datenbank
- 89-25-8(CAS DataBase Reference)
- NIST chemische Informationen
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)
- EPA chemische Informationen
- 1-Phenyl-3-methyl-5-pyrazolone (89-25-8)
3-Methyl-1-phenyl-5-pyrazolon Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Edaravone was marketed in Japan for improving neurologic recovery
following acute brain infarction. Currently, several agents classified as neuroprotectants
and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium
channels, lazaroids) have been marketed for treating the outcomes of brain damage due to
trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical
scavenging activity to be introduced for this pathology. This previously described molecule
(in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be
simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone
is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema
in the brain following ischemia by blocking the arachidonic acid cascade triggering
peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active
oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during
reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.
Chemische Eigenschaften
Off white to light yellow powder
Verwenden
Edaravone inhibits the disease activity in rheumatoid arthritis.
Definition
ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.
Allgemeine Beschreibung
A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC
50 = 15 μM). Inhibits mitochondrial permeability transition pore.
Hazard
Toxic by ingestion.
Biologische Aktivität
A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.
Sicherheitsprofil
Moderately toxic by ingestion andintraperitoneal routes. An eye irritant. When heated todecomposition it emits toxic fumes of NOx.
läuterung methode
Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]
3-Methyl-1-phenyl-5-pyrazolon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Methyl-1-phenyl-5-pyrazolon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 868)Lieferanten
89-25-8(3-Methyl-1-phenyl-5-pyrazolon)Verwandte Suche:
- 3-METHYL-1-PHENYL-5-PYROZOLENE
- AKOS B029819
- developerz
- Methylphenylpyrazolone
- NCI-C03952
- norantipyrine
- NSC-12
- NSC-26139
- NSC-2629
- 1-Phenyl-3-methyl-5-pyrazolon
- 1-Phenyl-3-methylpyrazolone
- 1-Phenyl-3-methylpyrazolone-5
- 1-Phenyl-3-methyl-2-pyrazolin-5-one
- 1-Phenyl-3-methyl-5(4H)-pyrazolone
- 3-Methyl-1-phenyl-5(4H)-pyrazolone
- 3-Methyl-1-phenyl-2-pyrazolin-5-one,99%
- 1-Phenyl-3-methyl-5-pyrazalone PMP
- 1-pheny-3-methyl-5-pyrazolone
- 1-pheny-3-methyl-5-p
- 3-Methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
- 3-Methyl-1-phenyl-2-pyrazolin-5-one, 99% 100GR
- 3-Methyl-1-phenyl-2-pyrazolin-5-one, 99% 5GR
- 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-o
- 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE FOR
- Edaravone (MCI-186)
- Monopyrazolone
Edaravone
- 1-pheny-3-Methyl-5-pyrazolone (PMP)
- 3-Methyl-1-phenyl-2-pyrazolin-5-one
(Edaravone)
- 3-Methyl-1-phenyl-2-pyrazoline-5-one 99%
- ORGANIC DYE INTERMEDIATES 1-PHENYL 3-METHYL-5 PYRAZOLONE (PMP)
- 3-Methyl-1-phenyl-2-pyrazolin-5-one for synthesis
- 5-Methyl-2-phenyl-,2-dihydropyrazol-3-one
- TIMTEC-BB SBB003801
- 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
- 3-methyl-1-phenyl-2-pyrazolin-5-on
- 3-Methyl-1-phenylpyrazol-5-one
- 3-Methyl-1-phenylpyrazolin-5-one
- 5-Pyrazolone, 3-methyl-1-phenyl-
- Developer Z
- 3-Methyl-1-pehnyl-2-pyrazolin-5-one
- 3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+%
- Radicu
- 3-Methyl-1-phenyl-5-pyrazolido
- 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
- N-demethylantipyrine
- Radicut
- 3-Methyl-1-phenylpyrazolin-5(4H)-one
- 5-Methyl-2-phenyl-1H-pyrazol-3-one
- MCI-186
- C.I. Developer 1
- AURORA KA-3365
- 2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one
- 5-METHYL-2-PHENYL-2,4-DIHYDRO-PYRAZOL-3-ONE
- 2-dihydropyrazol-3-one
- 5-Methyl-2-phenyl-1
- 1,3,5- pyrazolone (1- phenyl -3- methyl -5- pyrazolone)
- 3-Methyl-1-phenyl-2-pyrazolin-5-one, 98%, a strong novel free radical scavenger
- edaravone-008
