Pyridin-2,3-dicarbonsure

Quinolinic acid Struktur
89-00-9
CAS-Nr.
89-00-9
Bezeichnung:
Pyridin-2,3-dicarbonsure
Englisch Name:
Quinolinic acid
Synonyma:
PYRIDINE-2,3-DICARBOXYLIC ACID;2,3-PYRIDINEDICARBOXYLIC ACID;QUIN;2,3-Pyridinedicarboxylic;Pyridine-2,3-dicarboxylate;2,3-PyridinedicarboxylicAcid99%;109/KG;NSC 18836;NSC 13127;NSC 403247
CBNumber:
CB7316162
Summenformel:
C7H5NO4
Molgewicht:
167.12
MOL-Datei:
89-00-9.mol

Pyridin-2,3-dicarbonsure Eigenschaften

Schmelzpunkt:
188-190 °C (dec.) (lit.)
Siedepunkt:
295.67°C (rough estimate)
Dichte
1.5216 (rough estimate)
Brechungsindex
1.6280 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit
10g/l
Aggregatzustand
Crystalline Powder
pka
2.43(at 25℃)
Farbe
White to light yellow-beige
Geruch (Odor)
odorless
Wasserlöslichkeit
0.55 g/100 mL
Merck 
14,8073
BRN 
137110
InChIKey
GJAWHXHKYYXBSV-UHFFFAOYSA-N
CAS Datenbank
89-00-9(CAS DataBase Reference)
EPA chemische Informationen
2,3-Pyridinedicarboxylic acid (89-00-9)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38-33
S-Sätze: 26-36/37-24/25-37
WGK Germany  3
RTECS-Nr. US7967250
TSCA  T
HazardClass  IRRITANT
HS Code  29333999
Giftige Stoffe Daten 89-00-9(Hazardous Substances Data)
Toxizität Focal injection of quinolinic acid into specific areas of the brain produces neuronal damage although sparing axons of passage. Similarities between the biochemical and morphological profiles of these lesions and human neuropathy seen in neurodegenerative diseases have led to the proposal that endogenous excitotoxins may play a role in such neurodegenerative disease states. Quinolinic acid is an intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals including man. The neuroexcitatory action is thought to be mediated via interaction with the N-methyl-D-aspartate (NMDA) receptor of the glutamate family. No mechanism for quinolinic acid removal, nor for synaptic inactivation, has been found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur.
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Pyridin-2,3-dicarbonsure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R33:Gefahr kumulativer Wirkungen.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37:Geeignete Schutzhandschuhe tragen.

Chemische Eigenschaften

White powder;Light yellow powder

Verwenden

Quinolinic acid is an endogenous NMDA agonist. Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid is an ?excitotoxic? metabolite and an agonist of N-methyl-D-aspartate receptors. properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders. Quinolinic acid is a potent endogenous excitant at amino acid receptors in CNS.

Hazard

A poison by skin contact. Moderately toxic by ingestion. A mild skin irritant.

Industrielle Verwendung

The use of quinolinic acid during flotation of hematite results in the adsorption of quinoline on hematite, allowing amine to selectively adsorb onto the hematite surface.

Biologische Aktivität

Endogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.

Sicherheitsprofil

A poison by skin contact. Moderately toxic by ingestion. Experimental reproductive effects. A mdd skinn irritant. When heated to decomposition it emits toxic vapors of NOx.

Pyridin-2,3-dicarbonsure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pyridin-2,3-dicarbonsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 564)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
+8613288715578
sales@hbmojin.com China 12457 58
Hebei Guanlang Biotechnology Co,.LTD
+8619930503252
daisy@crovellbio.com China 5964 58
shandong exelon biochem co.ld
+86-533-2119995 +8615053330977
451614802@QQ.com China 28 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
sales@frappschem.com China 885 50
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21695 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763
info@tnjchem.com China 2989 55
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10248 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58

89-00-9(Pyridin-2,3-dicarbonsure)Verwandte Suche:


  • QuinolinicAcid>99%
  • Pyridin-2,3-dicarbonsaeure
  • 2,3-PYRIDINEDICARBOXYLIC ACID (QUINOLINIC ACID)
  • 2,3-pyridine dicarbo
  • AKOS BBS-00003814
  • AKOS AUF2085
  • Quinolinic Acid 99%
  • 2,3-Pyridinedicarboxylic acid, 99% 100GR
  • 2,3-Pyridinedicarboxylic acid, 99% 25GR
  • NSC 13127
  • NSC 18836
  • NSC 403247
  • 2,3-PYRIDINEDICARBOXYLIC ACID FOR SYNTHE
  • Pyridinecarboxylic acid-2,3- two
  • 2,3-Pyridinedicarboxylic acid 99%
  • 2,3-PYRIDINEDICARBOXYLIC ACID AKOS AUF2085
  • 2,3-pyridinediacrboxylic acid
  • Pyridine-2,3-dicarboxylic acid (quinolinic acid)
  • 109/KG
  • 2,3-Pyridinedicarboxylic acid Vetec(TM) reagent grade, 98%
  • RARECHEM AL BO 0810
  • QUINOLIC ACID
  • QUINOLINIC ACID
  • 2,3 PYRIDINE DICARBOXYLIC ACID (AS PER INVOICE AND PACKING LIST)
  • PYRIDINE-2,3-DICARBOXYLI ACID
  • 2,3-PyridinedicarboxylicAcid>
  • Pyridine-2,3-Dicarboxylic Acid,99%,
  • 2,3-PyridinedicarboxyL
  • 2,3-PyridinedicarboxylicAcid99%
  • 2,3-Pyridinedicarboxylic
  • 2,3-PYRIDINEDICARBOXYLIC ACID
  • PYRIDINE-2,3-DICARBOXYLIC ACID
  • Pyridine-2,3-dicarboxylate
  • QUIN
  • Quinolinic acid (2,3-pyridinedihydroxy acid)
  • Pyridine Dicarbonylic Acid
  • 89-00-9
  • 98-00-9
  • Building Blocks
  • C7 and C8
  • CARBOXYLIC ACID
  • Pyridines
  • Quinolines
  • Heterocyclic Building Blocks
  • Pyridine series
  • Pyridine
  • pyridine derivative
  • Carboxylic Acids
  • Pyridines
  • Heterocyclic Compounds
  • Heterocycles
  • Inhibitors
  • Carboxylic Acids
  • Medical Intermediates
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Pesticides intermediate
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