퀴놀린

퀴놀린
퀴놀린 구조식 이미지
카스 번호:
91-22-5
한글명:
퀴놀린
동의어(한글):
퀴놀린;1-아자나프탈렌;1-벤즈아진;1-벤진;벤조(B)피리딘;키놀렌;로이콜;로;1-벤즈아젠;벤조[b]피리딘;벤조피리딘
상품명:
Quinoline
동의어(영문):
Quinolin;1-Benzaine;Leukol;BENZO[B]PYRIDINE;Quinoline, synthetic, 99%;b-500;B 500;Leucol;CHINOLIN;ai3-01241
CBNumber:
CB2331254
분자식:
C9H7N
포뮬러 무게:
129.16
MOL 파일:
91-22-5.mol
MSDS 파일:
SDS

퀴놀린 속성

녹는점
-17--13 °C (lit.)
끓는 점
113-114 °C/11 mmHg (lit.) 237 °C (lit.)
밀도
1.093 g/mL at 25 °C (lit.)
증기 밀도
4.5 (vs air)
증기압
0.07 mm Hg ( 20 °C)
굴절률
n20/D 1.625(lit.)
인화점
214 °F
저장 조건
Store below +30°C.
용해도
6g/L
물리적 상태
액체
산도 계수 (pKa)
4.9(at 20℃)
색상
보라색에서 진한 회색까지
냄새
강하고 불쾌합니다.
수소이온지수(pH)
7.3 (5g/l, H2O, 20℃)
폭발한계
1.2-7%(V)
?? ??
약용
수용성
약간 용해됨
감도
Light Sensitive & Hygroscopic
Merck
14,8068
BRN
107477
Dielectric constant
2.6(-180℃)
안정성
안정적인. 강산, 강산화제와 호환되지 않습니다. 빛에 노출되면 변색될 수 있습니다. 흡습성 - 습기로부터 보호합니다. 일부 물질, 특히 강한 산화제와 격렬하고 예측할 수 없게 반응합니다.
InChIKey
SMWDFEZZVXVKRB-UHFFFAOYSA-N
LogP
2.04 at 22℃
CAS 데이터베이스
91-22-5(CAS DataBase Reference)
IARC
2B (Vol. 121) 2019
NIST
Quinoline(91-22-5)
EPA
Quinoline (91-22-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,N,T
위험 카페고리 넘버 21/22-38-41-68-40-37/38-51/53-36/38-45
안전지침서 26-36/37/39-36-23-61-45-53
유엔번호(UN No.) UN 2656 6.1/PG 3
WGK 독일 2
RTECS 번호 VA9275000
F 고인화성물질 8
자연 발화 온도 896 °F
TSCA Yes
위험 등급 6.1
포장분류 III
HS 번호 29334900
유해 물질 데이터 91-22-5(Hazardous Substances Data)
독성 LD50 orally in rats: 460 mg/kg (Smyth)
기존화학 물질 KE-02719
유해화학물질 필터링 2013-1-667
중점관리물질 필터링 별표1-38
함량 및 규제정보 물질구분: 유독물질; 혼합물(제품)함량정보: 퀴놀린 및 0.1% 이상 함유한 혼합물
그림문자(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H312 피부와 접촉하면 유해함 급성 독성 물질 - 경피 구분 4 경고 GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H341 유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 생식세포 변이원성 물질 구분 2 경고 P201,P202, P281, P308+P313, P405,P501
H350 암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 1A, 1B 위험 GHS hazard pictograms
H411 장기적 영향에 의해 수생생물에 유독함 수생 환경유해성 물질 - 만성 구분 2
예방조치문구:
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
2
3 0

퀴놀린 C화학적 특성, 용도, 생산

용도

알칼로이드· 퀴놀린 염료 등의 합성원료가 되며, 미량 중금속이온의 정량분석 시약으로도 사용된다.

화학적 성질

Quinoline is a colorless liquid with a penetrating amine odor. Turns brown on exposure to light.

출처

Quinoline was discovered in coal tar distillate in 1834 by Runge. It is released to the environment through natural combustion processes and has been isolated from air particulates (Dong et al 1977). Quinoline may be a significant aqueous byproduct of synthetic fuel production (shale oil, coal processing) and from wood preservation production and use facilities. Small amounts also have been detected in tobacco smoke (Schmeltz and Hoffmann 1977).

용도

Quinoline is used in the manufacture of dyesand hydroxyquinoline salts; as a solvent forresins and terpenes; and therapeutically as anantimalarial agent. It occurs in coal tar insmall amounts.

생산 방법

Quinoline may be synthesized by heating aniline with glycerol and nitrobenzene in sulfuric acid (Skraup method) or by reacting aniline, acetaldehyde, and a formaldehyde hemiacetal (Windholz et al 1983). Commercial production is by isolation from coal tar with greater than 100,000 lbs being produced in 1977. Production of refined quinoline has almost ceased due to low demand (Parris et al 1983).

정의

ChEBI: The simplest member of the quinoline class of compounds, comprising a benzene ring ortho fused to C-2 and C-3 of a pyridine ring.

일반 설명

A colorless liquid with a peculiar odor. Slightly denser than water. Contact may irritate to skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals.

공기와 물의 반응

Hygroscopic. Soluble in water.

반응 프로필

Quinoline is hygroscopic. Quinoline absorbs as much as 22% water. Quinoline is sensitive to light and moisture. Quinoline darkens on storage. Quinoline is a weak base. A potentially explosive reaction may occur with hydrogen peroxide. Quinoline reacts violently with dinitrogen tetraoxide. Quinoline also reacts violently with perchromates. Quinoline is incompatible with (linseed oil + thionyl chloride) and maleic anhydride. Quinoline is also incompatible with strong oxidizers and strong acids. Quinoline can be unpredictably violent. Quinoline dissolves sulfur, phosphorus and arsenic trioxide. Quinoline may attack some forms of plastics. Quinoline is a preparative hazard.

건강위험

No industrial injuries from quinoline exposure have been reported. Handling precautions similar to those taken for pyridine are recommended (EOHS 1971).
Clinical signs of toxicity include lethargy, respiratory distress, and coma; cause of death is respiratory paralysis. Quinoline is a skin and eye irritant; it may cause permanent corneal injury (EOHS 1971).
Routine occupational exposure to quinoline probably constitutes low risk for acute toxicity. Long-term exposure to low concentrations may increase cancer risk.

화학 반응

Reactivity with Water No reaction; Reactivity with Common Materials: Attacks some forms of plastics; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

공업 용도

Quinoline is used as a solvent for resins and terpenes. It also is used as an antimalarial, an antioxidant, a catalyst and as an intermediate in the manufacture of various products (Parris et al 1983).

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. Moderately toxic by skin contact. A skin and severe eye irritant. Mutation data reported. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. It can cause retinitis sdar to that caused by naphthalene but without causing opacity of the lens. Combustible when exposed to heat or flame. Its preparation has caused many industrial explosions. Potentially explosive reaction with hydrogen peroxide. Violent reaction with dmtrogen tetraoxide, perchromates. Incompatible with linseed oil + thionyl chloride, maleic anhydride, Unpredctably violent. When heated to decomposition it emits toxic fumes of NOx.

잠재적 노출

In manufacture of quinoline deriva- tives (dyes and pesticides); in synthetic fuel manufacture. Occurs in cigarette smoke.

Carcinogenicity

Liver tumors were observed in rats administered diets containing 0.05–0.25% quinoline. The incidence of hepatocellular carcinomas was 3/11 at 0.05%, 3/16 at 0.1%, and 0/19 at 0.25% versus 0/6 in controls. At 0.25%, most of the rats died within 40 weeks. The incidences of hemangioendotheliomas were 6/11, 12/16, 18/19, and 0/6, respectively. Hepatocellular carcinomas and hemangioendotheliomas were seen in livers of rats fed 500, 1000, or 2500 ppm for 16–40 weeks. Typical hyperplasias were also observed in the liver.

환경귀착

biodegradative processes occur under aerobic conditions. Anaerobic degradation is minimal (Mill et al 1981). Breakdown of quinoline in natural waters has been correlated with bacterial concentration (Rogers et al 1984). Adsorption was high in acidic soils (pH<6) and low in basic soils (pH>7). The presence of pyridine decreased quinoline adsorption on acidic, but not basic, soils. Sorption did not correlate with organic carbon or clay content (Felice et al 1984). Soil bacteria have been grown with quinoline as the sole carbon source (Grant and Al-Najjar 1976). Quinoline did not bioconcentrate to a significant extent in fathead minnows (Southworth et al 1980).

운송 방법

UN2656 Quinoline, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

비 호환성

Reacts, possibly violently, with strong oxidants, strong acids; perchromates, nitrogen tetroxide; and maleic anhydride. Keep away from moisture, steam, and light. Contact with hydrogen peroxide may cause explosion. Unpredictably violent, this substance has been the source of various plant accidents.

폐기물 처리

Dissolve or mix the material with a combustible solvent and burn in a chemical incinera- tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

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