1,1,1,3,3,3-Hexafluorpropan-2-ol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/22:Gesundheitsschädlich beim Einatmen und Verschlucken.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
Chemische Eigenschaften
1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a
clear, colorless, oily, combustible liquid. Odor is described
as aromatic.
Verwenden
1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.
Definition
ChEBI: An organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane.
Allgemeine Beschreibung
1,1,1,3,3,3-Hexafluoro-2-propanol is a solution-phase peptide chemistry solvent. This fluorinated polar solvent of high ionizing power facilitates Friedel–Crafts-type reactions, using covalent reagents in the absence of a Lewis acid catalyst. It also enhances the efficiency of rhodium(I)-catalyzed [4+2] intramolecular cycloaddition of ether-tethered alkynyl dienes and [5+2] cycloaddition of alkynyl vinylcyclopropanes. 1,1,1,3,3,3-Hexafluoro-2-propanol clusters catalyzes the epoxidation of cyclooctene and 1-octene with hydrogen peroxide.
Air & Water Reaktionen
Water soluble.
Reaktivität anzeigen
1,1,1,3,3,3-Hexafluoro-2-propanol is incompatible with acids, acid chlorides and oxidizing agents.
Brandgefahr
1,1,1,3,3,3-Hexafluoro-2-propanol is probably combustible.
mögliche Exposition
A specialty solvent for some poly mers; a lavatory reagent.
Versand/Shipping
UN1760 Corrosive liquids, n.o.s., Hazard class: 8;
Labels: 8-Corrosive material.
läuterung methode
Distil it from 3A molecular sieves, retaining the middle fraction. It has been prepared by reduction of hexafluoroacetone in tetrahydrofuran (THF), In this case hexafluoropropanol forms a stable 1:1 complex which distils at 99-100o/760mm (n 25 1.3283), The complex is decomposed by mixing with 20% oleum and distilling in a vacuum, and the distillate is redistilled to give pure hexafluoropropan-2-ol with b 59o/760mm. The 1H NMR shows a doublet at 4.52ppm (JH,H 2Hz). The benzoyl derivative, [10315-85-2] M 272.1, has m 53.9o after crystalllisation from pentane at -50o, and its IR has at 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] It has very high peptide solubilising properties, alone or with CH2Cl2 [use as a solvent: Narita et al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] It is CORROSIVE, causes severe eye irritation.
Inkompatibilitäten
HFIP is incompatible with acids, acid
chlorides, and oxidizing agents.
Waste disposal
May be incinerated. In accor dance with 40CFR165, follow recommendations for the
disposal of pesticides and pesticide containers. Must be dis posed properly by following package label directions or by
contacting your local or federal environmental control
agency, or by contacting your regional EPA office. Consult
with environmental regulatory agencies for guidance on
acceptable disposal practices. Generators of waste contain ing this contaminant (≥100 kg/mo) must conform to EPA
regulations governing storage, transportation, treatment,
and waste disposal.
1,1,1,3,3,3-Hexafluorpropan-2-ol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Bromcyan
2-Propanol, 1,1,1,2,3,3,3-heptafluoro-
2-(TRIMETHYLSILOXY)PENTAFLUOROPROPENE
Methyl 3,3,3-Trifluoro-2-hydroxy-2-trifluoromethylpropionate
Chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether
Phenylformiat
Ammoniumtrifluoracetat
Hexachloraceton
Hexafluoraceton
Natriumtrifluoracetat
Downstream Produkte
