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Disoprofol Produkt Beschreibung

Propofol Struktur
2078-54-8
CAS-Nr.
2078-54-8
Bezeichnung:
Disoprofol
Englisch Name:
Propofol
Synonyma:
Anepol;Ivofol;PD18215;AMpofol;Aquafol;Recofol;DIPRIVAN;Dipravan;Fresofol;NSC 5105
CBNumber:
CB4101882
Summenformel:
C12H18O
Molgewicht:
178.27
MOL-Datei:
2078-54-8.mol

Disoprofol Eigenschaften

Schmelzpunkt:
18 °C (lit.)
Siedepunkt:
256 °C/764 mmHg (lit.)
Dichte
0.962 g/mL at 25 °C (lit.)
Dampfdruck
5.6 mm Hg ( 100 °C)
Brechungsindex
n20/D 1.514(lit.)
Flammpunkt:
>230 °F
storage temp. 
2-8°C
Löslichkeit
Very slightly soluble in water, miscible with hexane and with methanol
Aggregatzustand
neat
pka
pKa 11.10(H2O,t =20)(Approximate)
Wasserlöslichkeit
Very slightly soluble in water.
Merck 
14,7834
BRN 
1866484
InChIKey
OLBCVFGFOZPWHH-UHFFFAOYSA-N
CAS Datenbank
2078-54-8(CAS DataBase Reference)
NIST chemische Informationen
Phenol, 2,6-bis(1-methylethyl)-(2078-54-8)
EPA chemische Informationen
2,6-Diisopropylphenol (2078-54-8)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,T,F
R-Sätze: 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
S-Sätze: 26-36/37/39-37/39-36-45-36/37-16-7
RIDADR  2810
WGK Germany  3
RTECS-Nr. SL0810000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29089990
Giftige Stoffe Daten 2078-54-8(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P311 GIFTINFORMATIONSZENTRUM/Arzt anrufen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Disoprofol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Propofol is an injectable, short-acting general anesthetic with a low incidence of side effects.

Chemische Eigenschaften

Light Yellow Liquid

Originator

ICI (United Kingdom)

Verwenden

2,6-DIPP is the active ingredient for intravenous anesthetic formulations, also has applications as an intermediate for polymers

Verwenden

A anesthetic used in veterinary medicine

Verwenden

Propofol is an anesthetic used in veterinary medicine.

Trademarks

Diprivan (Abraxis);Disoprivan;Disprofol;Rapinovet.

Weltgesundheitsorganisation (WHO)

Propofol, a short acting injectable anaesthetic, was introduced in 1987. In April 1992, the Norwegian Medicines Control Board reported that prolonged use of propofol had been associated with two fatalities in children characterized by metabolic acidosis, liver enlargement, and cerebral oedema. The UK Committee on the Safety of Medicines has received 5 reports of deaths occurring in children who had received propofol while in intensive care.

Biologische Funktion

Propofol (Diprivan) is rapidly acting, has a short recovery time, and possesses antiemetic properties. A rapid onset of anesthesia (50 seconds) is achieved, and if no other drug is administered, recovery will take place in 4 to 8 minutes.The recovery is attributed to redistribution of the drug and rapid metabolism to glucuronide and sulfate conjugates by the liver and extrahepatic tissues, such as intestine and kidney.
Rapid recovery and its antiemetic properties make propofol anesthesia very popular as an induction agent for outpatient anesthesia. Propofol can also be used to supplement inhalational anesthesia in longer procedures. Both continuous infusion of propofol for conscious sedation and with opioids for the maintenance of anesthesia for cardiac surgery are acceptable techniques.

Synthesis Reference(s)

The Journal of Organic Chemistry, 21, p. 712, 1956 DOI: 10.1021/jo01112a621

Allgemeine Beschreibung

Propofol is an injectable sedative–hypnotic used for the inductionand maintenance of anesthesia or sedation. Propofolis only slightly soluble in water with an octanol/water partitioncoefficient of 6,761:1; thus, it is formulated as an oil-inwateremulsion. The fat component of the emulsion consistsof soybean oil, glycerol, and egg lecithin. The pKa of thepropanol hydroxyl is 11 and the injectable emulsion has apH of 7 to 8.5. Formulations contain either disodium ethylenediaminetetraaceticacid (EDTA) (0.005%) or sodiummetabisulfite to retard the growth of microorganisms. EDTAis a metal chelator and patients on propofol containingEDTA for extended periods of time excrete more zinc andiron in their urine. The clinical consequence of this is notknown but the manufacturer recommends that a drug holidayor zinc supplementation be considered after 5 days of therapy.

Biologische Aktivität

Intravenous general anesthetic and hypnotic with a mode of action which includes potentiation of GABA-mediated inhibitory synaptic transmission, direct activation of the GABA A receptor and inhibition of glutamate receptor mediated excitatory synaptic transmission. Also potentiates P2X 4 receptor-mediated currents in P2X 4 -HEK293 cells.

Pharmakologie

Propofol is primarily a hypnotic drug with substantial cardiorespiratory depressant actions and with no ability to produce neuromuscular blockade. While propofol lacks analgesic properties, its use permits lower doses of opioids. Likewise, less propofol is required for adequate hypnosis when it is administered with opioids.Thus, it is said that propofol and opioids interact synergistically.

Clinical Use

Generic formulations of propofol may contain sodiummetabisulfite as the antimicrobial agent, and patients allergicto sulfites, especially asthmatic patients, should avoid thisformulation. Aseptic technique must be followed and unusedportions of the drug must be discarded according to the manufacturer’s instructions to prevent microbial contaminationand possible sepsis.

Nebenwirkungen

The dose of propofol should be reduced in older patients; however, it does have a relatively linear dose– response characteristic, and patients generally can be safely titrated. The pain on injection, especially when small veins are used, can be considerably reduced if lidocaine 20 mg is administered first.
Anesthesia induction with propofol causes a significant reduction in blood pressure that is proportional to the severity of cardiovascular disease or the volume status of the patient, or both. However, even in healthy patients a significant reduction in systolic and mean arterial blood pressure occurs. The reduction in pressure appears to be associated with vasodilation and myocardial depression. Although propofol decreases systemic vascular resistance, reflex tachycardia is not observed. This is in contrast to the actions of thiopental. The heart rate stabilization produced by propofol relative to other agents is likely the result of either resetting or inhibiting the baroreflex, thus reducing the tachycardic response to hypotension.
Since propofol does not depress the hemodynamic response to laryngoscopy and intubation, its use may permit wide swings in blood pressure at the time of induction of anesthesia. Propofol should be used with utmost caution in patients with cardiac disease.

Sicherheitsprofil

Poison by intravenous and intraperitoneal routes. Experimental reproductive effects. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also PHENOL

Veterinary Drugs and Treatments

In appropriate patients, propofol may be useful as an induction agent (especially before endotracheal intubation or an inhalant anesthetic), and as an anesthetic for outpatient diagnostic or minor procedures (e.g., laceration repair, radiologic procedures, minor dentistry, minor biopsies, endoscopy, etc.).
Propofol is used as a treatment for refractory status epilepticus, as it tends to cause less cardiovascular depression and recoveries can be smoother than with pentobarbital. Propofol may be of particular usefulness for use in Greyhounds and in patients with preexisting cardiac dysrhythmias. At low dosages, propofol is being investigated as an appetite stimulant in dogs.
Propofol may be safely used in animals with liver or renal disease and mild to moderate cardiac disease.
In dogs, propofol’s labeled indications are: 1) for induction of anesthesia; 2) for maintenance of anesthesia for up to 20 minutes; 3) for induction of general anesthesia where maintenance is provided by inhalant anesthetics.

Disoprofol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Disoprofol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 349)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shanghai CRM New Material Technology Co., LTD
+8613020139835
Whatsapp:+8613020139835 Wickr me:lucyzxy lucy@shanghaicrm.com China 300 58
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD
+8617731987558
xingjiu@xingjiubiotech.com China 999 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26762 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58

2078-54-8(Disoprofol)Verwandte Suche:


  • 2,6-DIISOPROPYLPHENOL
  • 2,6-BIS(1-METHYLETHYL)PHENOL
  • Diprivan10
  • Disoprofol
  • PD18215
  • Phenol, 2,6-diisopropyl-
  • Phenol,2,6-bis(1-methylethyl)-
  • Phenol,2,6-diisopropyl-
  • propofol(INN)
  • DISOPRIVAN
  • DIPRIVAN
  • ICI-35868
  • Dipravan
  • AMpofol
  • Anepol
  • Aquafol
  • Diprifusor
  • Fresofol
  • Ivofol
  • NSC 5105
  • Propofol USP
  • Propofol Ph. Eur.
  • 2,6- twoisopropyl phenol
  • Propofol solution
  • Propofol RAPINOVET
  • RAPINOVET
  • PROPOFOL
  • PROPOTOL
  • 2,6-bis(1-methylethyl)-pheno
  • 2,6-Bis(isopropyl)phenol
  • 2,6-diisopropyl-pheno
  • 2 6-DIISOPROPYLPHENOL 97+%
  • PROPOFOL(2,6-DIISOPROPYLPHENOL)
  • 2,6-Diisopropylphenol, tech., 90%
  • 2,6-Bis(1-methylethyl)phenol, ICI-35868, Disoprivan, Rapinovet
  • 2,6-Diisopropyl
  • 2,6-DIISOPROPYLPHENOL / PROPOFOL
  • 2,6-DIISOPROPYLPHENOL 98+%
  • 2,6-Diisopropylphenol, 99% 5GR
  • 2,6-Bis(Isopropyl)-phenol, Dipravan, Propofol
  • Disopfivan
  • Diprofol
  • Recofol
  • 2,6-Diisopropylphenol ,99%
  • Dipriban
  • 2,6-Diisopropylphenol,90%,tech.
  • ICI 35868, Dipravan
  • 2,6-Diisopropylphenol,2,6-Bis(isopropyl)phenol, Propofol
  • Propofol (200 mg)
  • 2,6-bis(propan-2-yl)phenol
  • Propofol for peak identification CRS
  • 2,6-Diisopropylphenol >
  • Propofol CRS
  • 2078-54-8
  • 2078-84-8
  • CH32CH2C6H3OH
  • C3H72C6H3OH
  • Oxygen Compounds
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