2,6-디이소프로필페놀
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2,6-디이소프로필페놀 속성
- 녹는점
- 18 °C (lit.)
- 끓는 점
- 256 °C/764 mmHg (lit.)
- 밀도
- 0.962 g/mL at 25 °C (lit.)
- 증기압
- 5.6 mm Hg ( 100 °C)
- 굴절률
- n
20/D 1.514(lit.)
- 인화점
- >230 °F
- 저장 조건
- 2-8°C
- 용해도
- 물에 매우 약간 용해되며 헥산 및 메탄올과 섞임
- 산도 계수 (pKa)
- pKa 11.10(H2O,t =20)(Approximate)
- 물리적 상태
- <18°C Solid,>18°C Liquid
- 색상
- 연한 노란색에서 노란색까지
- 냄새
- 100.00?%. 약한 페놀성
- 수용성
- 물에 아주 약간 용해됩니다.
- Merck
- 14,7834
- BRN
- 1866484
- InChIKey
- OLBCVFGFOZPWHH-UHFFFAOYSA-N
- LogP
- 3.790
- CAS 데이터베이스
- 2078-54-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11 | ||
안전지침서 | 26-36/37/39-37/39-36-45-36/37-16-7 | ||
유엔번호(UN No.) | 2810 | ||
WGK 독일 | 3 | ||
RTECS 번호 | SL0810000 | ||
TSCA | Yes | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29089990 | ||
유해 물질 데이터 | 2078-54-8(Hazardous Substances Data) | ||
독성 | dog,LD50,intravenous,30mg/kg (30mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 1117, 1996. | ||
기존화학 물질 | KE-03284 |
2,6-디이소프로필페놀 C화학적 특성, 용도, 생산
개요
Propofol is an injectable, short-acting general anesthetic with a low incidence of side effects.화학적 성질
Light Yellow Liquid용도
Propofol is an anesthetic used in veterinary medicine.World Health Organization (WHO)
Propofol, a short acting injectable anaesthetic, was introduced in 1987. In April 1992, the Norwegian Medicines Control Board reported that prolonged use of propofol had been associated with two fatalities in children characterized by metabolic acidosis, liver enlargement, and cerebral oedema. The UK Committee on the Safety of Medicines has received 5 reports of deaths occurring in children who had received propofol while in intensive care.Biological Functions
Propofol (Diprivan) is rapidly acting, has a short recovery time, and possesses antiemetic properties. A rapid onset of anesthesia (50 seconds) is achieved, and if no other drug is administered, recovery will take place in 4 to 8 minutes.The recovery is attributed to redistribution of the drug and rapid metabolism to glucuronide and sulfate conjugates by the liver and extrahepatic tissues, such as intestine and kidney.Rapid recovery and its antiemetic properties make propofol anesthesia very popular as an induction agent for outpatient anesthesia. Propofol can also be used to supplement inhalational anesthesia in longer procedures. Both continuous infusion of propofol for conscious sedation and with opioids for the maintenance of anesthesia for cardiac surgery are acceptable techniques.
일반 설명
Propofol is an injectable sedative–hypnotic used for the inductionand maintenance of anesthesia or sedation. Propofolis only slightly soluble in water with an octanol/water partitioncoefficient of 6,761:1; thus, it is formulated as an oil-inwateremulsion. The fat component of the emulsion consistsof soybean oil, glycerol, and egg lecithin. The pKa of thepropanol hydroxyl is 11 and the injectable emulsion has apH of 7 to 8.5. Formulations contain either disodium ethylenediaminetetraaceticacid (EDTA) (0.005%) or sodiummetabisulfite to retard the growth of microorganisms. EDTAis a metal chelator and patients on propofol containingEDTA for extended periods of time excrete more zinc andiron in their urine. The clinical consequence of this is notknown but the manufacturer recommends that a drug holidayor zinc supplementation be considered after 5 days of therapy.생물학적 활성
Intravenous general anesthetic and hypnotic with a mode of action which includes potentiation of GABA-mediated inhibitory synaptic transmission, direct activation of the GABA A receptor and inhibition of glutamate receptor mediated excitatory synaptic transmission. Also potentiates P2X 4 receptor-mediated currents in P2X 4 -HEK293 cells.Pharmacology
Propofol is primarily a hypnotic drug with substantial cardiorespiratory depressant actions and with no ability to produce neuromuscular blockade. While propofol lacks analgesic properties, its use permits lower doses of opioids. Likewise, less propofol is required for adequate hypnosis when it is administered with opioids.Thus, it is said that propofol and opioids interact synergistically.Clinical Use
Generic formulations of propofol may contain sodiummetabisulfite as the antimicrobial agent, and patients allergicto sulfites, especially asthmatic patients, should avoid thisformulation. Aseptic technique must be followed and unusedportions of the drug must be discarded according to the manufacturer’s instructions to prevent microbial contaminationand possible sepsis.부작용
The dose of propofol should be reduced in older patients; however, it does have a relatively linear dose– response characteristic, and patients generally can be safely titrated. The pain on injection, especially when small veins are used, can be considerably reduced if lidocaine 20 mg is administered first.Anesthesia induction with propofol causes a significant reduction in blood pressure that is proportional to the severity of cardiovascular disease or the volume status of the patient, or both. However, even in healthy patients a significant reduction in systolic and mean arterial blood pressure occurs. The reduction in pressure appears to be associated with vasodilation and myocardial depression. Although propofol decreases systemic vascular resistance, reflex tachycardia is not observed. This is in contrast to the actions of thiopental. The heart rate stabilization produced by propofol relative to other agents is likely the result of either resetting or inhibiting the baroreflex, thus reducing the tachycardic response to hypotension.
Since propofol does not depress the hemodynamic response to laryngoscopy and intubation, its use may permit wide swings in blood pressure at the time of induction of anesthesia. Propofol should be used with utmost caution in patients with cardiac disease.
Safety Profile
Poison by intravenous and intraperitoneal routes. Experimental reproductive effects. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also PHENOL2,6-디이소프로필페놀 준비 용품 및 원자재
원자재
준비 용품
2,6-디이소프로필페놀 공급 업체
글로벌( 439)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD | +8617731987558 |
xingjiu@xingjiubiotech.com | China | 990 | 58 |
Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 |
Ethan@dornechem.com | China | 3129 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5892 | 58 |
Hong Kong Excellence Biotechnology Co., Ltd. | |
ada@sh-teruiop.com | China | 882 | 58 |
Hebei Dangtong Import and export Co LTD | +86-13910575315 +86-13910575315 |
admin@hbdangtong.com | China | 1005 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 436 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 |
Sara@xmwonderfulbio.com | China | 305 | 58 |
Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 |
xinshengkeji@xsmaterial.com | China | 1090 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
2,6-디이소프로필페놀 관련 검색:
N,N-다이아이소프로필에틸아민 2,6-자일렌올 디이소프로필벤젠 N-메틸-2-피롤리디논 다이아이소프로필아민 2,6-다이아이소프로필나프탈렌 1,3-디이소프로필 카보디아미드 이소프로필페놀 3,5-디아이소프로필페놀 4,4′-메틸렌비스(2,6-디-3차-부틸페놀) 부틸산화 히드록시톨루엔 2,6-디-t-부틸-4-에틸페놀 2,6-디-t-b부틸페놀 스테아릴-β-(3,5-디-t-부틸-4-하이드록시페닐)프로피오네이트 2,4,6-트리-터셔리-부틸페놀 2,6-디이소프로필페놀
Diethyl isopropylmalonate
DIISOPROPYL ZINC 1.0M SOLUTION IN TOLU&