Carnosic acid

Carnosic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

Yellow powder

Verwenden

Carnosic Acid is a phenolic component of rosemary. It acts as a potent antioxdant and also has UV protective activity. Specifically protection for UV-A radiation and damage. Carnosic Acid also inhibits the free-radical chain reaction that leads to the oxidation of fats and oils, thereby stabilizing and increasing the shelf life of meats.

Definition

ChEBI: An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from Rosmarinus officinalis and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.

Anticancer Research

Carnosic acid is a diterpene found in rosemary (Rosmarinus officinalis), exhibitinganti-proliferative effects when observed in vitro in human renal carcinoma cells andcervical carcinoma cells (Su et al. 2016) including inhibition of cell proliferation,angiogenesis and cell migration. ER stress is induced by the carnosic acid present inthe extract from rosemary, inducing cancer cell apoptosis (Cao and Kaufman 2014;Petiwala et al. 2014). Carnosic acid induced dose-dependent expression of ATF4and CHOP and knockdown of CHOP and ATF4 by siRNA-suppressed apoptosis.
The role of ROS was investigated in the induction of ER stress by carnosic acid.ATF4 and CHOP expression induced by carnosic acid was markedly inhibited byROS scavengers. Hence, this information implies that ATF4 and CHOP expressionmediated by ER stress plays a significant part in apoptosis of human kidney Cakicells induced by carnosic acid (Min et al. 2014). Treatment of 22Rv1 and LNCaP,human prostate cancer cell lines, by carnosic acid degraded the androgen receptor(AR), and antigen specific to the prostate also showed reduced expression.Proteasomal degradation pathway dependent on ER stress mediates AR degradation.Induction of CHOP protein, degradation of AR and reduction in the growth ofxenograft prostate cancer tumours by 53% were also detected in vivo. Additionally,carnosic acid induces ER stress only in prostate cancer cells and not in normal cells(Petiwala et al. 2016).

Carnosic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Carnosic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Changsha Staherb Natural Ingredients Co., Ltd.	+86-0731-84213302 +8618374838656	sales@staherb.cn	China	1025	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	269	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+86-13474506593 +86-13474506593	sarah@tnjone.com	China	874	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	282	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	401	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58

3650-09-7()Verwandte Suche:

---

• CARNOSOLIC ACID
• CARNOSIC ACID
• 4a(2H)-Phenanthrenecarboxylic acid, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,10aS)-
• (4aR,10aS)-5,6-dihydroxy-1,1-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthrene-4a-carboxylic acid
• CARNOSIC ACID(P)
• CARNOSIC ACID(P)(NOW AVAILABLE IN GRAM SIZES)(P)
• salvin
• (4aR-trans)-1,3,4,9,10,10a-Hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-4a(2H)-phenanthrenecarboxylic acid
• Carnosic acid from Rosmarinus officinalis
• CARNOSIC ACID(RG)
• Carnosic Acid, Free Acid, >99%
• Deoxypicrosalvinic acid
• 1,3,4,9,10,10aS-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-4aR(2H)-phenanthrenecarboxylic acid Carnosic acid
• Carnosic acid, >=95%
• Carnosic acid, 99%, from Rosmarinus officinalis L.
• Carnosic Acid (Synthetic)
• Soluble CARNOSIC ACID, Liposomal CARNOSIC ACID, CARNOSIC ACID NanoEmulsion, NanoActive CARNOSIC ACID, BETA- CARNOSIC ACID
• Carnosic acid, 99%, from Rosmarinus officinalis
• Carnosic acid 5-95%
• Carnosic Acid >
• carnosicaci
• hot selling Carnosic acid
• Carnosic acid USP/EP/BP
• (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-4a-carboxylic Acid
• carnosic acid oil
• carosic acid
• Murine tail oxalic acid
• Rosemary Extract Carnosic Acid Powder
• Miltiorrhiza Extract Tanshinone
• 3650-09-7
• 3650-9-7
• 6537-80-8
• 360-09-7
• 9005-64-6
• 8604-14-8
• reference standards from Chinese medicinal herbs (TCM).
• standardized herbal extract
• Plant extracts
• Miscellaneous Natural Products
• chemical reagent
• pharmaceutical intermediate
• phytochemical