Cerivastatin sodium

Cerivastatin sodium Struktur
143201-11-0
CAS-Nr.
143201-11-0
Englisch Name:
Cerivastatin sodium
Synonyma:
BAYCOL;BAY-w 6228;Rivastatin hydrate;Cerivastatin sodium;Rivastatin, Baycol, Lipobay;Cerivastatin-13C-d3 Sodium Salt;Cerivastatin sodium salt hydrate;Sodium 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-dipropan-2-yl-pyrid in-3-yl]-3,5-dihydroxy-hept-6-enoate;(3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(MethoxyMethyl)-2,6-bis(1-Methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic Acid SodiuM Salt;(3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate
CBNumber:
CB5115264
Summenformel:
C26H35FNNaO5
Molgewicht:
483.56
MOL-Datei:
143201-11-0.mol

Cerivastatin sodium Eigenschaften

Schmelzpunkt:
197-199°C
alpha 
D20 +24.1° (c = 1 in ethanol)
storage temp. 
Hygroscopic, Store under Inert atmosphere -20°C Freezer
Löslichkeit
H2O: ≥5mg/mL
Aggregatzustand
powder
Farbe
white to tan
Optische Aktivität
[α]/D +18 to +26° in ethanol
Stabilität:
Hygroscopic
CAS Datenbank
143201-11-0(CAS DataBase Reference)

Sicherheit

WGK Germany  3

Cerivastatin sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Lipobay was launched in Denmark, Germany and the UK for treatment of primary hypercholesteremia types Ⅱa and Ⅱb. It is available through a nine step synthesis beginning with the Hantsch reaction of ethyl 3-amino-4-methylpent-2-enoate and 4-(ethoxycarbonyl)-5-(4-fluorophenyl)-2-methylpent-4-en-3-one. Lipobay acts as an HMG-CoA reductase inhibitor showing a high liver selectivity (50 fold). In vitro Lipobay had a higher affinity (110x) for the enzyme than does Lovastatin, Simvastatin and pravastatin which resulted in a lower ED50, in vivo compared to Lovastatin. Three metabolites generated by the CYP3A4 enzyme system were equal to the parent in activity. Lipobay was as effective as Gemfibrozil in type lib hypercholesteremia and had no age or gender effects. It decreased plasma levels of VLDL and LDL cholesterol by a mechanism similar to other HMG-CoA reductase inhibitors. The (-)- antipode is completely inactive indicating a high stereospecificity by the enzyme. It is therapeutically useful at ultra-low doses which may minimize any drug-drug interactions.

Chemische Eigenschaften

Solid

Verwenden

Cerivastatin sodium salt hydrate has been used as a supplement in cell culture.

Definition

ChEBI: The sodium salt of cerivastatin. Formerly used to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.

Allgemeine Beschreibung

Cerivastatin sodium salt hydrate belongs to the statin class of lipid lowering agents. It helps in decreasing MAP kinase activation, blocking AP-1 (activator protein-1) and NF-kB (nuclear factor-kB ) binding activity, inhibiting inflammatory responses and ameliorated renal damage. It also lowers cholesterol. It is metabolized by cytochrome P450 (CYP)3A4 and (CYP)2C8. Cerivastatin sodium salt hydrate is linked to rhabdomyolysis.

Hazard

A poison by ingestion.

Cerivastatin sodium Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cerivastatin sodium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 71)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49392 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 8232 58
Finetech Industry Limited
+86-27-87465837 +8618971612321
info@finetechnology-ind.com China 9640 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52861 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418684 +8618949823763
sales@tnjchem.com China 25363 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 50003 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131980 58
Mainchem Co., Ltd. +86-0592-6210733
sale@mainchem.com China 32360 55

143201-11-0()Verwandte Suche:


  • BAYCOL
  • 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, monosodium salt, (3R,5S,6E)-
  • 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, monosodium salt, [S-[R*,S*-(E)]]-
  • BAY-w 6228
  • Cerivastatin sodium
  • Sodium 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-dipropan-2-yl-pyrid in-3-yl]-3,5-dihydroxy-hept-6-enoate
  • Rivastatin, Baycol, Lipobay
  • (3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(MethoxyMethyl)-2,6-bis(1-Methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic Acid SodiuM Salt
  • (3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate
  • Cerivastatin sodium salt hydrate
  • Rivastatin hydrate
  • Cerivastatin-13C-d3 Sodium Salt
  • 143201-11-0
  • 145599-86-0
  • C26H33FNNaO5
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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