2-Tolylboronic acid
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- CAS-Nr.
- 16419-60-6
- Englisch Name:
- 2-Tolylboronic acid
- Synonyma:
- O-TOLYLBORONIC ACID;O-TOLYBORONIC ACID;2-METHYLPHENYLBORONIC ACID;2-METHYLBENZENEBORONIC ACID;2-ToL;AKOS BRN-0017;o-Boronotoluene;o-Tolylboronic ac;2-Tolylboronicaci;RARECHEM AH PB 0228
- CBNumber:
- CB5186691
- Summenformel:
- C7H9BO2
- Molgewicht:
- 135.96
- MOL-Datei:
- 16419-60-6.mol
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2-Tolylboronic acid Eigenschaften
- Schmelzpunkt:
- 162-164 °C(lit.)
- Siedepunkt:
- 283.4±33.0 °C(Predicted)
- Dichte
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Löslichkeit
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 8.61±0.58(Predicted)
- Aggregatzustand
- Crystalline Powder
- Farbe
- Beige
- Wasserlöslichkeit
- Slightly soluble in water.
- BRN
- 2935796
- InChI
- InChI=1S/C7H9BO2/c1-6-4-2-3-5-7(6)8(9)10/h2-5,9-10H,1H3
- InChIKey
- NSJVYHOPHZMZPN-UHFFFAOYSA-N
- SMILES
- B(C1=CC=CC=C1C)(O)O
- CAS Datenbank
- 16419-60-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
36/37/38 |
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| S-Sätze: |
26-36-37/39 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
ED7777777 |
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| HazardClass |
IRRITANT |
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| HS Code |
29163990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P271 |
Nur im Freien oder in gut belüfteten Räumen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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2-Tolylboronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Physikalische Eigenschaften
beige crystalline powder
Verwenden
suzuki reaction
Synthese
Triphenylphosphene (0.131 g, 0.5 mmol, 20 mol %), p-iodoanisol (0.585 g, 2.5 mmol), and triethylamine (1.78 mL, 12.5 mmol) were added to a 50 mL round-bottomed flask equipped with a sidearm, condenser, and stir bar. This solution was then degassed by alternating vacuum and argon three times. Palladium dichloride (0.023 g, 0.13 mmol, 5 mol %) was then added under positive argon pressure. After stirring at room temperature for 15 min, diisopropylaminoborane (5 mL, 1 M solution in THF, 5 mmol) was added and the reaction mixture was degassed again by alternating vacuum and argon three times. The reaction solution was then heated to reflux. After 12 h of reflux the reaction was cooled to 0 °C and 6 mL of methanol was added through the condenser slowly (Caution: exothermic reaction with evolution of hydrogen). After 15 min of stirring all the solvent was removed under reduced pressure to yield a black solid. This solid was dissolved with sodium hydroxide (3 M, 8 mL) and subsequently washed with hexanes (3×10 mL). The aqueous layer was then cooled to 0 °C (ice bath) and acidified to pH ≤1 with concentrated HCl, with the boronic acid usually precipitating out as a white solid. The aqueous fraction was then extracted with diethyl ether (3×10 mL). The organic fractions were combined, dried with magnesium sulfate and filtered. The solvent was then removed under reduced pressure yielding a white solid named 2-Tolylboronic acid.
2-Tolylboronic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Tolylboronic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 445)Lieferanten
16419-60-6()Verwandte Suche:
- AKOS BRN-0017
- 2-TOLYLBORONIC ACID
- TOLUENE-2-BORONIC ACID
- O-METHYLPHENYLBORONIC ACID
- o-Tolylboronic acid, 2-Boronotoluene
- Boronicacid, B-(2-Methylphenyl)-
- 2-Tolylboronic acid
2-Methylphenylboronic acid
- 2-Methyl-1-phenylboronic acid
- o-Tolylboronic acid >=95.0%
- o-Tolylboronic ac
- RARECHEM AH PB 0228
- 2-TOLYLBORONIC ACID(2-Methylbenzeneboronic acid)
- 2-Methylpenylboronic Acid
- 2-Methylphenylboronic
- o-Tolylboronicacid,min.97%
- 2-METHYLPHENYLBORONIC ACID, O-TOLYBORONIC ACID
- 2-METHYLSUFINYLPHENYLBORONIC ACID
- 2-Methylphenylboronic Acid (contains varying amounts of Anhydride)
- 2-Methylphenylboronic acid (o-Tolylboronic acid)
- 2-Tolueneboronic acid
- o-Boronotoluene
- 2-Tolylboronic acid ,98%
- o-Tolylboronic acid, min. 97%
- 2-Tolylboronic acid,95%
- 2-Methylphenylboronic acid, May contain varying amounts of anhydride, 95%
- 2-Tolylboronic acid, 95% 1GR
- 2-Methylbenzeneboronic Acid
o-Tolylboronic Acid
- 2-ToL
- 2-Tolylboronicaci
- 2-methylbenzoborate
- 2-Tolylboronic acid 16419-60-6
- 2-Methylphenylboronic Acid extrapure, 97%
- 2-METHYLPHENYLBORONIC ACID
- 2-METHYLBENZENEBORONIC ACID
- O-TOLYLBORONIC ACID
- O-TOLYBORONIC ACID
- Eltrombopag Impurity 33
- 16419-60-6
- 16419-60-9
- C7H9BO2
- C7H9O2B
- BORONIC ACID
- Organometallic Reagents
- B (Classes of Boron Compounds)
- Boronic Acids
- Boronic Acids and Derivatives
- Aryl
- Substituted Boronic Acids
- organic or inorganic borate
- Boron, Nitrile, Thio,& TM-Cpds
- blocks
- BoronicAcids
- Boronic Acid series
- B (Classes of Boron Compounds)
- Boronic Acids
- CHIRAL CHEMICALS
- Boronic Acid
- Aryl
