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Carboxymethyl cellulose Produkt Beschreibung

Carboxymethyl cellulose  Struktur
9004-32-4
CAS-Nr.
9004-32-4
Englisch Name:
Carboxymethyl cellulose
Synonyma:
b10;cmc2;s75m;7h3sf;carbo;cmc7h;cmc7m;cmc41a;cmc4h1;cmc4m6
CBNumber:
CB5209844
Summenformel:
C6H7O2(OH)2CH2COONa
Molgewicht:
0
MOL-Datei:
Mol file

Carboxymethyl cellulose Eigenschaften

Schmelzpunkt:
274 °C (dec.)
Dichte
1,6 g/cm3
FEMA 
2239 | CARBOXYMETHYLCELLULOSE
storage temp. 
room temp
Löslichkeit
H2O: 20 mg/mL, soluble
Aggregatzustand
low viscosity
pka
4.30(at 25℃)
Farbe
White to light yellow
PH
pH (10g/l, 25℃) 6.0~8.0
Wasserlöslichkeit
soluble
Merck 
14,1829
Stabilität:
Stable. Incompatible with strong oxidizing agents.
EPA chemische Informationen
Cellulose, carboxymethyl ether, sodium salt(9004-32-4)

Sicherheit

R-Sätze: 40
S-Sätze: 24/25
WGK Germany  1
RTECS-Nr. FJ5950000
3
Selbstentzündungstemperatur 698 °F
TSCA  Yes
HS Code  39123100

Carboxymethyl cellulose Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R40:Verdacht auf krebserzeugende Wirkung.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

Carboxymethylcellulose sodium occurs as a white to almost white, odorless, tasteless, granular powder. It is hygroscopic after drying.

Chemische Eigenschaften

solid

Verwenden

In drilling muds, in detergents as a soil-suspending agent, in resin emulsion paints, adhesives, printing inks, textile sizes, as protective colloid in general. As stabilizer in foods. Pharmaceutic aid (suspending agent; tablet excipient; viscosity-increasing agent).

Verwenden

cellulose gum (Carboxymethyl cellulose) is a thickener, binder, and emulsifier equivalent to cellulose fiber. It is resistant to bacterial decomposition and provides a product with uniform viscosity. It can prevent skin moisture loss by forming a film on the skin’s surface, and also help mask odor in a cosmetic product. Constituents are any of several fibrous substances consisting of the chief part of a plant’s cell walls (often extracted from wood pulp or cotton).

Definition

A semisynthetic, water-soluble polymer in which CH 2 COOH groups are substituted on the glucose units of the cellulose chain through an ether link- age. Mw ranges from 21,000 to 500,000. Since the reaction occurs in an alkaline medium, the prod- uct is the sodium salt of the carboxylic acid R-O- CH 2 COONa.

Vorbereitung Methode

Alkali cellulose is prepared by steeping cellulose obtained from wood pulp or cotton fibers in sodium hydroxide solution. The alkaline cellulose is then reacted with sodium monochloroacetate to produce carboxymethylcellulose sodium. Sodium chloride and sodium glycolate are obtained as by-products of this etherification.

Trademarks

Celluvisc (Allergan); Refresh Plus, Cellufresh Formula (Allergan).

Pharmazeutische Anwendungen

Carboxymethylcellulose sodium is widely used in oral and topical pharmaceutical formulations, primarily for its viscosity-increasing properties. Viscous aqueous solutions are used to suspend powders intended for either topical application or oral and parenteral administration. Carboxymethylcellulose sodium may also be used as a tablet binder and disintegrant, and to stabilize emulsions.
Higher concentrations, usually 3–6%, of the medium-viscosity grade are used to produce gels that can be used as the base for applications and pastes; glycols are often included in such gels to prevent them drying out. Carboxymethylcellulose sodium is also used in self-adhesive ostomy, wound care, and dermatological patches as a muco-adhesive and to absorb wound exudate or transepidermal water and sweat. This muco-adhesive property is used in products designed to prevent post-surgical tissue adhesions; and to localize and modify the release kinetics of active ingredients applied to mucous membranes; and for bone repair. Encapsulation with carboxymethylcellulose sodium can affect drug protection and delivery. There have also been reports of its use as a cyto-protective agent.
Carboxymethylcellulose sodium is also used in cosmetics, toiletries, surgical prosthetics, and incontinence, personal hygiene, and food products.

Sicherheitsprofil

Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. It migrates to food from packagmg materials. When heated to decomposition it emits toxic fumes of NazO. See also POLYMERS, SOLUBLE.

Sicherheit(Safety)

Carboxymethylcellulose sodium is used in oral, topical, and some parenteral formulations. It is also widely used in cosmetics, toiletries, and food products, and is generally regarded as a nontoxic and nonirritant material. However, oral consumption of large amounts of carboxymethylcellulose sodium can have a laxative effect; therapeutically, 4–10 g in daily divided doses of the medium- and high-viscosity grades of carboxymethylcellulose sodium have been used as bulk laxatives.
The WHO has not specified an acceptable daily intake for carboxymethylcellulose sodium as a food additive since the levels necessary to achieve a desired effect were not considered to be a hazard to health. However, in animal studies, subcutaneous administration of carboxymethylcellulose sodium has been found to cause inflammation, and in some cases of repeated injection fibrosarcomas have been found at the site of injection.
Hypersensitivity and anaphylactic reactions have occurred in cattle and horses, which have been attributed to carboxymethylcellulose sodium in parenteral formulations such as vaccines and penicillins.
LD50 (guinea pig, oral): 16 g/kg
LD50 (rat, oral): 27 g/kg

Lager

Carboxymethylcellulose sodium is a stable, though hygroscopic material. Under high-humidity conditions, carboxymethylcellulose sodium can absorb a large quantity (>50%) of water. In tablets, this has been associated with a decrease in tablet hardness and an increase in disintegration time.
Aqueous solutions are stable at pH 2–10; precipitation can occur below pH 2, and solution viscosity decreases rapidly above pH 10. Generally, solutions exhibit maximum viscosity and stability at pH 7–9.
Carboxymethylcellulose sodium may be sterilized in the dry state by maintaining it at a temperature of 1608℃ for 1 hour. However, this process results in a significant decrease in viscosity and some deterioration in the properties of solutions prepared from the sterilized material.
Aqueous solutions may similarly be sterilized by heating, although this also results in some reduction in viscosity. After autoclaving, viscosity is reduced by about 25%, but this reduction is less marked than for solutions prepared from material sterilized in the dry state. The extent of the reduction is dependent on the molecular weight and degree of substitution; higher molecular weight grades generally undergo a greater percentage reduction in viscosity. Sterilization of solutions by gamma irradiation also results in a reduction in viscosity.
Aqueous solutions stored for prolonged periods should contain an antimicrobial preservative.
The bulk material should be stored in a well-closed container in a cool, dry place.

läuterung methode

Dialyse it for 48hours against distilled water and freeze-dry if a solid is required.

Inkompatibilitäten

Carboxymethylcellulose sodium is incompatible with strongly acidic solutions and with the soluble salts of iron and some other metals, such as aluminum, mercury, and zinc. It is also incompatible with xanthan gum. Precipitation may occur at pH < 2, and also when it is mixed with ethanol (95%).
Carboxymethylcellulose sodium forms complex coacervates with gelatin and pectin. It also forms a complex with collagen and is capable of precipitating certain positively charged proteins.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; intraarticular, intrabursal, intradermal, intralesional, and intrasynovial injections; oral drops, solutions, suspensions, syrups and tablets; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Carboxymethyl cellulose Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Carboxymethyl cellulose Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 303)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21956 58
Dalian Richfortune Chemicals Co., Ltd
86-411-84820922, 84821539
86-411-84821380 sales@richfortunechem.com China 360 57
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1787 55
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 3911 58
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816 whatsapp +8618034554576
86-0311-83975816 grace@hbhuanhao.com CHINA 704 58
Kono Chem Co., Ltd
+86-132 8924 6953(Whatsapp/Wechat)
+86-29-86107037 info@konochemical.com CHINA 2540 58

9004-32-4()Verwandte Suche:


  • CARBOXYMETHYL CELLULOSE, SODIUM SALT, AV ERAGE MW CA. 250,000, DS = 0.7
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  • VistecD.1.
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