ChemicalBook
Chinese english Germany Japanese Korea

Bretyliumtosilat Produkt Beschreibung

BRETYLIUM TOSYLATE Struktur
61-75-6
CAS-Nr.
61-75-6
Bezeichnung:
Bretyliumtosilat
Englisch Name:
BRETYLIUM TOSYLATE
Synonyma:
ornid;asl-603;bretylol;bretylan;darentin;darenthin;bretylate;esulfonicacid;ulfonicacid(1:1);BretyliuM p-Tolu
CBNumber:
CB5239348
Summenformel:
C18H24BrNO3S
Molgewicht:
414.36
MOL-Datei:
61-75-6.mol

Bretyliumtosilat Eigenschaften

Schmelzpunkt:
97-99°
Löslichkeit
H2O: soluble50mg/mL
Farbe
white
InChIKey
KVWNWTZZBKCOPM-UHFFFAOYSA-M

Sicherheit

Kennzeichnung gefährlicher Xn
R-Sätze: 20/21/22
S-Sätze: 36
RTECS-Nr. BO9450000
HS Code  2923900100
Toxizität LD50 in mice (mg/kg): 400 orally; 250 i.m. (Goldenthal)

Bretyliumtosilat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White Solid

Verwenden

Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade. Bretylium tosylate is a class III antiarrhythmic agent and a competitive inhibitor of acetylcholinesterase.

Definition

ChEBI: The tosylate salt of bretylium. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibril ation.

Trademarks

Bretylol (Mayne).

Allgemeine Beschreibung

Bretylium tosylate, (o-bromobenzyl)ethyl dimethylammonium p-toluenesulfonate(Bretylol), is an extremely bitter, white, crystalline powder.The chemical is freely soluble in water and alcohol.Bretylium tosylate is an adrenergic neuronal-blockingagent that accumulates selectively in the neurons anddisplaces norepinephrine. Because of this property,bretylium was used initially, under the trade name ofDarenthin, as an antihypertensive agent. It caused posturaldecrease in arterial pressure. This use was discontinuedbecause of the rapid development of tolerance, erratic oralabsorption of the quaternary ammonium compound, andpersistent pain in the parotid gland on prolonged therapy.

Clinical Use

Currently, bretylium is reserved for use in ventriculararrhythmias that are resistant to other therapy. Bretyliumdoes not suppress phase 4 depolarization, a common actionof other antiarrhythmic agents. It prolongs the effectiverefractory period relative to the action potential durationbut does not affect conduction time and is categorized asa class III antiarrhythmic agent. Because bretylium doesnot have properties similar to those of the other antiarrhythmicagents, it has been suggested that its action is aresult of its adrenergic neuronal-blocking properties; theantiarrhythmic properties of the drug, however, are notaffected by administration of reserpine. Bretylium is also alocal anesthetic, but it has not been possible to demonstratesuch an effect on atria of experimental animals, except atvery high concentrations. Therefore, the precise mechanismof the antiarrhythmic action of bretylium remains tobe resolved.

Bretyliumtosilat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Bretyliumtosilat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 55)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Wuhan ariel chemical Co., LTD. 18986259541 027-87840182 QQ:390889093
027-87840182 QQ:390889093 sales@3stc.com China 3610 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32362 50
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9847 79
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 QQ:452520369
+86 (573) 82222643 sales@maya-r.com China 11740 57
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 shlschemical@hotmail.com China 9915 55
Haoyuan Chemexpress Co., Ltd. 86-21-58998985
(86) 21-58955996 apisales@chemexpress.com.cn China 7560 61
UHN Shanghai Research & Development Co., Ltd. +86 (21) 5895-8002
+86 (21) 5895-8628 sales@uhnshanghai.com China 1036 58
HBCChem, Inc. +1-510-219-6317
+1-650-486-1361 sales@hbcchem.com United States 10661 60

61-75-6(Bretyliumtosilat)Verwandte Suche:


  • 2-bromo-n-ethyl-n,n-dimethyl-benzenemethanaminiusaltwith4-methylbenzenes
  • asl-603
  • bretylan
  • bretylate
  • bretyliump-toluenesulfonate
  • Bretyliumtosilate
  • bretylol
  • darenthin
  • [O-BROMOBENZYL]ETHYLDIMETHYL-AMMONIUM P-TOLUENESULFONATE
  • BRETYLIUM TOSYLATE
  • BRETYLIUM TOSYLATE ADRENERGIC NEURON BLO
  • BRETYLIUM TOSYLATE, PHARMA
  • 2-bromo-n-ethyl-n,n-dimethylbenzenemethanaminium
  • Bretyliume tosylate
  • Retylium tosylate
  • (2-bromobenzyl)-ethyl-dimethyl-ammonium
  • (2-bromophenyl)methyl-ethyl-dimethylazanium
  • (2-bromophenyl)methyl-ethyl-dimethyl-azanium
  • (2-Bromobenzyl)ethyldimethylammonium p-toluenesulfonate
  • (o-bromobenzyl)ethyldimethyl-ammoniup-toluenesulfonate
  • 2-bromo-n-ethyl-n,n-dimethylbenzenemethanaminium4-methylbenzenesulfonate
  • 2-bromo-n-ethyl-n,n-dimethyl-benzenemethanaminiusaltwith4-methylbenzen
  • darentin
  • dimethylethyl-o-bromobenzylammonium-p-toluenesulphonate
  • esulfonicacid
  • n-ethyl-n-o-bromobenzyl-n,n-dimethylammoniumtosylate
  • ornid
  • ulfonicacid(1:1)
  • Bretylium Tosylate (200 mg)
  • BretyliuM p-Tolu
  • N-(2-BroMobenzyl)-N,N-diMethylethanaMiniuM 4-Methylbenzenesulfonate
  • BretyliuM Tosylate USP
  • 61-75-6
  • C11H17BrNC7H7O3S
  • C18H24BO3RnS
  • C18H24BrNO3S
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
Copyright 2019 © ChemicalBook. All rights reserved