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BRETYLIUM TOSYLATE

BRETYLIUM TOSYLATE 구조식 이미지
카스 번호:
61-75-6
상품명:
BRETYLIUM TOSYLATE
동의어(영문):
ornid;asl-603;bretylol;bretylan;darentin;darenthin;bretylate;esulfonicacid;ulfonicacid(1:1);BretyliuM p-Tolu
CBNumber:
CB5239348
분자식:
C18H24BrNO3S
포뮬러 무게:
414.36
MOL 파일:
61-75-6.mol

BRETYLIUM TOSYLATE 속성

녹는점
97-99°
용해도
H2O: soluble50mg/mL
색상
white
InChIKey
KVWNWTZZBKCOPM-UHFFFAOYSA-M

안전

위험품 표기 Xn
위험 카페고리 넘버 20/21/22
안전지침서 36
RTECS 번호 BO9450000
독성 LD50 in mice (mg/kg): 400 orally; 250 i.m. (Goldenthal)

BRETYLIUM TOSYLATE C화학적 특성, 용도, 생산

화학적 성질

White Solid

용도

Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade. Bretylium tosylate is a class III antiarrhythmic agent and a competitive inhibitor of acetylcholinesterase.

정의

ChEBI: The tosylate salt of bretylium. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibril ation.

상표명

Bretylol (Mayne).

일반 설명

Bretylium tosylate, (o-bromobenzyl)ethyl dimethylammonium p-toluenesulfonate(Bretylol), is an extremely bitter, white, crystalline powder.The chemical is freely soluble in water and alcohol.Bretylium tosylate is an adrenergic neuronal-blockingagent that accumulates selectively in the neurons anddisplaces norepinephrine. Because of this property,bretylium was used initially, under the trade name ofDarenthin, as an antihypertensive agent. It caused posturaldecrease in arterial pressure. This use was discontinuedbecause of the rapid development of tolerance, erratic oralabsorption of the quaternary ammonium compound, andpersistent pain in the parotid gland on prolonged therapy.

Clinical Use

Currently, bretylium is reserved for use in ventriculararrhythmias that are resistant to other therapy. Bretyliumdoes not suppress phase 4 depolarization, a common actionof other antiarrhythmic agents. It prolongs the effectiverefractory period relative to the action potential durationbut does not affect conduction time and is categorized asa class III antiarrhythmic agent. Because bretylium doesnot have properties similar to those of the other antiarrhythmicagents, it has been suggested that its action is aresult of its adrenergic neuronal-blocking properties; theantiarrhythmic properties of the drug, however, are notaffected by administration of reserpine. Bretylium is also alocal anesthetic, but it has not been possible to demonstratesuch an effect on atria of experimental animals, except atvery high concentrations. Therefore, the precise mechanismof the antiarrhythmic action of bretylium remains tobe resolved.

BRETYLIUM TOSYLATE 준비 용품 및 원자재

원자재

준비 용품


BRETYLIUM TOSYLATE 공급 업체

글로벌( 52)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Wuhan ariel chemical Co., LTD. 18986259541 027-87840182 QQ:390889093
027-87840182 QQ:390889093 sales@3stc.com China 3510 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32363 50
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9851 79
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 QQ:452520369
+86 (573) 82222643 sales@maya-r.com China 11744 57
Shanghai LiuShi Pharmaceutical Technology Co., Ltd. 021-60135539
021-38721356 shlschemical@hotmail.com China 9915 55
Haoyuan Chemexpress Co., Ltd. 86-21-58998985
(86) 21-58955996 apisales@chemexpress.com.cn China 7560 61
UHN Shanghai Research & Development Co., Ltd. +86 (21) 5895-8002
+86 (21) 5895-8628 sales@uhnshanghai.com China 1036 58
HBCChem, Inc. +1-510-219-6317
+1-650-486-1361 sales@hbcchem.com United States 10665 60
Bide Pharmatech Ltd. +86-21-61629020
+86-21-61629029 product@bidepharmatech.com China 40176 60

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