Lomefloxacin hydrochloride
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- CAS-Nr.
- 98079-52-8
- Englisch Name:
- Lomefloxacin hydrochloride
- Synonyma:
- LOMEFLOXACIN HCL;1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride;ny198;omefL;Okacyn;Okacin;bareon;Chimono;Uniquin;LoMflox
- CBNumber:
- CB5723616
- Summenformel:
- C17H20ClF2N3O3
- Molgewicht:
- 387.81
- MOL-Datei:
- 98079-52-8.mol
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Lomefloxacin hydrochloride Eigenschaften
- Schmelzpunkt:
- 290-3000C
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- 1 M NaOH: soluble50mg/mL
- Aggregatzustand
- powder to crystal
- Farbe
- white to off-white
- Merck
- 14,5562
- CAS Datenbank
- 98079-52-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
VB1997500 |
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| HS Code |
29339900 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P272 |
Kontaminierte Arbeitskleidung nicht außerhalb des Arbeitsplatzes tragen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Lomefloxacin hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Beschreibung
Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment.
Chemische Eigenschaften
White powder with no smell, bitter taste
Verwenden
Fluorinated quinolone antibacterial. DNA gyrase antagonist
Definition
ChEBI: The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for
he treatment of otitis externa and otitis media.
Einzelnachweise
Wadworth, A. N., and K. L. Goa. "Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. " Drugs 42.6(1991): 1018-60.
Symonds, W. T., and D. E. Nix. "Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials." Clin Pharm 11.9(1992): 753-66.
Lomefloxacin hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lomefloxacin hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 373)Lieferanten
98079-52-8()Verwandte Suche:
- 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylicacimonohydrochloride
- bareon
- ny198
- sc-47111
- 1-ETHYL-6,8-DIFLUORO-1,4-DIHYDRO-7-[3-METHYL-1-PIPERAZINYL]-4-OXO-3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE
- LOMEFLOXACIN HYDROCHLORIDE
- Chimono
- Lomebact
- Maxaquin
- Okacin
- Okacyn
- 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-, monohydrochloride (9CI)
- Mazaquin
- Uniquin
- 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acimonohydrochloride
- bareonny
- Lomoefloxacin HCL
- LomefloxacineHCl
- Lomefloxacin hydroch
- Hydrochloric acid fleroxacin
- LoMefloxacin hydrochloride (Maxaquin)
- Alkaflox
- LoMef 400
- LoMflox
- LoMitas
- LoMoxin
- Orchacin
- Lomeflon
- Lomefloxcin hydrochloride
- Lomefloxacin hydrochloride,1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
- 1-Ethyl-6,8-difluoro-7-(3-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
- Lomefloxacin h
- 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, hydrochloride (1:1)
- Lomefloxacin·HCl≥ 99% (HPLC)
- Lomefloxacin hydrochloride USP/EP/BP
- Lomefloxacin HydrochlorideQ: What is
Lomefloxacin Hydrochloride Q: What is the CAS Number of
Lomefloxacin Hydrochloride Q: What is the storage condition of
Lomefloxacin Hydrochloride Q: What are the applications of
Lomefloxacin Hydrochloride
- Lomefloxacin Hydrochloride (LMF), 98.5%
- omefL
- Lomefloxacin Hydrochloride Standard
- LomefloxacinHydrochloride>
- LOMEFLOXACIN HCL
- 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride
- 98079-52-8
- C17H19F2N3O3HCl
- C17H20ClF2N3O3
- C17H19F2N3O3ClH
- Halogenated Heterocycles ,Benzothiazoles
- Antibiotics for Research and Experimental Use
- Biochemistry
- Quinolones (Antibiotics for Research and Experimental Use)
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Lomefloxacin
