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DL-Methionin Produkt Beschreibung

DL-Methionine Struktur
59-51-8
CAS-Nr.
59-51-8
Bezeichnung:
DL-Methionin
Englisch Name:
DL-Methionine
Synonyma:
MET;L-MET;Amurex;Dyprin;Metion;Neston;Cynaron;Meonine;Metione;Urimeth
CBNumber:
CB6208758
Summenformel:
C5H11NO2S
Molgewicht:
149.21
MOL-Datei:
59-51-8.mol

DL-Methionin Eigenschaften

Schmelzpunkt:
284 °C (dec.)(lit.)
alpha 
-1~+1°(D/20℃)(c=8,HCl)
Dichte
1.34
FEMA 
3301 | D,L-METHIONINE
Brechungsindex
1.5216 (estimate)
storage temp. 
0-6°C
Löslichkeit
1 M HCl: 0.5 M at 20 °C, clear, colorless
pka
2.13(at 25℃)
Aggregatzustand
Crystals or Crystalline Powder
Farbe
White
Optische Aktivität
[α]/D, c = 5 in 5 M HCl (inactive)
Wasserlöslichkeit
2.9 g/100 mL (20 ºC)
JECFA Number
1424
Merck 
14,5975
BRN 
636185
Stabilität:
Stable. Incompatible with strong oxidising agents.
CAS Datenbank
59-51-8(CAS DataBase Reference)
NIST chemische Informationen
Methionine(59-51-8)
EPA chemische Informationen
Methionine(59-51-8)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 33-36/37/38
S-Sätze: 24/25-36-26
WGK Germany  2
RTECS-Nr. PD0457000
10-23
TSCA  Yes
HS Code  29304090

DL-Methionin Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

FARBLOSE KRISTALLE ODER WEISSES PULVER.

CHEMISCHE GEFAHREN

Zersetzung beim Erhitzen unter Bildung giftiger Rauche mit Schwefeloxiden und Stickstoffoxiden.

ARBEITSPLATZGRENZWERTE

TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).

AUFNAHMEWEGE

Aufnahme in den Körper durch Verschlucken.

LECKAGE

Verschüttetes Material in Behältern sammeln. Reste sorgfältig sammeln. An sicheren Ort bringen.

R-Sätze Betriebsanweisung:

R33:Gefahr kumulativer Wirkungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Methionine is an α-amino acid with the chemical formula HO2CCH(NH2)CH2CH2SCH3. This essential amino acid is classified as nonpolar. This amino-acid is coded by the initiation codon AUG which indicates mRNA's coding region where translation into protein begins.

Chemische Eigenschaften

White, crystalline platelets or powder having a characteristic odor. One g dissolves in about 30 mL of water. It is soluble in dilute acids and in solutions of alkali hydroxides. It is very slightly soluble in alcohol, and practically insoluble in ether. It is optically inactive. The pH of a 1 in 100 solution is between 5.6 and 6.1. This substance may be prepared by addition of methanethiol to acrolein; by chemical conversion of methylthiopropionic aldehyde.

Chemische Eigenschaften

d,l-Methionine has a characteristic odor. It is an essential amino acid and is also used as a nutrient and dietary supplement.

Chemische Eigenschaften

White crystalline powder

Occurrence

High levels of methionine can be found in eggs, sesame seeds, Brazil nuts, fish, meats and some other plant seeds; methionine is also found in cereal grains. Most fruits and vegetables contain very little of it. Most legumes are also low in methionine. Racemic methionine is sometimes added as an ingredient to pet foods.

Verwenden

An essential nonpolar amino acid with oxidative stress defense properties

Verwenden

DL-Methionine is sometimes given as a supplement to dogs; it helps keep dogs from damaging grass by reducing the pH of the urine.
Methionine is allowed as a supplement to organic poultry feed under the US certified organic program.

synthetische

By addition of methanethiol to acrolein; by chemical conversion of methylthiopropionic aldehyde.

Definition

ChEBI: A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.

Trademarks

Pedameth (Forest).

Biosynthese

As an essential amino acid, methionine is not synthesized de novo in humans, who must ingest methionine or methioninecontaining proteins. In plants and microorganisms, methionine is synthesized via a pathway that uses both aspartic acid and cysteine. First, aspartic acid is converted via β-aspartyl-semialdehyde into homoserine, introducing the pair of contiguous methylene groups. Homoserine converts to O-succinyl homoserine, which then reacts with cysteine to produce cystathionine, which is cleaved to yield homocysteine. Subsequent methylation of the thiol group by folates affords methionine. Both cystathionine-γ-synthase and cystathionine- β-lyase require pyridoxyl-5′-phosphate as a cofactor, whereas homocysteine methyltransferase requires vitamin B12 as a cofactor.

Biotechnologische Produktion

DL-Methionine is the second amino acid that is almost exclusively manufactured by chemical synthesis. The process used today was originally developed by Werner Schwarze at Degussa in the 1940s, and has been continually improved and refined since. Today DL-methionine is manufactured in several plants, each with a capacity of more than 100,000 tonnes. To operate the process on an industrial scale also requires back-integration into the key hazardous raw materials acrolein, methyl mercaptan, and hydrogen cyanide. After the formation of the hydantoin, the key step is alkaline hydrolysis of the hydantoin, to produce methionine directly in up to 95 % yield based on acrolein.

Biologische Funktion

Together with cysteine, methionine is one of two sulfurcontaining proteinogenic amino acids. Its derivative S-adenosyl methionine (SAM) serves as a methyl donor. Methionine is an intermediate in the biosynthesis of cysteine, carnitine, taurine, lecithin, phosphatidylcholine, and other phospholipids. Improper conversion of methionine can lead to atherosclerosis.
This amino acid is also used by plants for synthesis of ethylene. The process is known as the Yang Cycle or the methionine cycle.
Methionine is one of only two amino acids encoded by a single codon (AUG) in the standard genetic code (tryptophan, encoded by UGG, is the other). The codon AUG is also the most common eukaryote "Start" message for a ribosome that signals the initiation of protein translation from mRNA when the AUG codon is in a Kozak consensus sequence. As a consequence, methionine is often incorporated into the N-terminal position of proteins in eukaryotes and archaea during translation, although it can be removed by post-translational modification. In bacteria, the derivative Nformylmethionine is used as the initial amino acid.

Sicherheitsprofil

Moderately toxic by ingestion and other routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx. See also 1-METHIONINE.

läuterung methode

Crystallise it from hot water or EtOH. Also purify it by dissolving it in H2O and passing through an Amberlite IR-120 resin (NH4+ form). The eluate is concentrated and then passed through Amberlite IR-4B resin, and this eluate is evaporated to dryness. The residue is washed with EtOH, then Me2CO, dried and recrystallised from aqueous EtOH (colourless plates) [Baddiley & Jamieson J Chem Soc 4283 1954]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2125 1961, Beilstein 4 IV 3190.]

Other biochemical pathways

Although mammals cannot synthesize methionine, they can still use it in a variety of biochemical pathways:
Generation of homocysteine Methionine is converted to S-adenosyl methionine (SAM) by (1) methionine adenosyltransferase.
SAM serves as a methyl-donor in many (2) methyl transferase reactions, and is converted to S-adenosylhomocysteine (SAH).
(3) Adenosyl homocysteinase converts SAH to homocysteine.
There are two fates of homocysteine: it can be used to regenerate methionine, or to form cysteine.
Regeneration of methionine
Methionine can be regenerated from homocysteine via methionine synthase in a reaction that requires Vitamin B12 as a cofactor.
Homocysteine can also be remethylated using glycine betaine (NNN-trimethyl glycine, TMG) to methionine via the enzyme betainehomocysteine methyltransferase (E.C.2.1.1.5, BHMT). BHMT makes up to 1.5% of all the soluble protein of the liver, and recent evidence suggests that it may have a greater influence on methionine and homocysteine homeostasis than methionine synthase.

DL-Methionin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


DL-Methionin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 454)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21701 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1852 55

59-51-8(DL-Methionin)Verwandte Suche:


  • 4-Methylmercapto-2-aminobutyricacid
  • alpha-Amino-gamma-methylmercaptobutyric acid
  • Amurex
  • Banthionine
  • butanoicacid,2-amino-4-(methylthio)-,DL-
  • Cynaron
  • DL-2-Amino-3-methylthiobuttersαure
  • Dyprin
  • L-CH3SCH2CH2CH(NH2)COOH
  • Lobamine
  • Meonine
  • Mertionin
  • Methilanin
  • Methilonin
  • Methionine (NF XIV)
  • Methionine dl-form
  • -Methylmercapto-aminobutyricacid
  • Metion
  • L-2-AMINO-4-METHYLMERCAPTOBUTYRIC ACID
  • L-2-AMINO-4-(METHYLTHIO)BUTANOIC ACID
  • acimetion
  • AKOS AUF2097
  • 2-AMINO-4-METHYLMERCAPTOBUTYRIC ACID
  • 2-AMINO-4-METHYLSULFANYL-BUTYRIC ACID
  • 2-AMINO-4(METHYLTHIO)BUTYRIC ACID
  • (S)-(+)-METHIONINE
  • (S)-2-AMINO-4-(METHYLMERCAPTO)BUTYRIC ACID
  • RACEMETHIONINE
  • (+/-)-2-Amino-4-(methylthio)butyric acid~H-DL-Met-OH
  • DL-Methoionine
  • DL METHIONINE FEED GRADE
  • DL-METHIONINE FEED GRADE / POULTRY
  • DL- MATHIONINE
  • DL-METHIONINE CELL CULTURE TESTED
  • DL-METHIONINE 98.5+% FCC
  • DL-Methionine FCC
  • DL-LETHIONINE
  • Dl-MethionineForBiochemistry99+%
  • DL-METHIONINE FOR BIOCHEMISTRY
  • DL-Methionine,99%
  • METHIONINUM
  • (n)-2-amino-4-(methylthio)butyric acid
  • DL-Methionine、AciMeti
  • DL-Methinonine
  • DL-Methionine(F
  • DL-Methionine Vetec(TM) reagent grade, 98%
  • BUFFER PH10 (20°C) AVS TITRINORM
  • BUFFER SOLUTION PH 4 AVS TITRINORM BOM
  • Kochia seed extract
  • DL-METHIONINE (METHYL-13C)
  • DL-METHIONINE (13C5,D8,15N)
  • DL-Met-OH
  • 200-432-1
  • Kochia fruit extract (10:1)
  • (RS)-Methionine
  • DL-Methionine≥ 99% (Titration)
  • H-DL-Met
  • FRUCTUS KOCHIAE
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