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Levoglutamid Produkt Beschreibung

L-Glutamine Struktur
56-85-9
CAS-Nr.
56-85-9
Bezeichnung:
Levoglutamid
Englisch Name:
L-Glutamine
Synonyma:
GLN;L-G;L-GLN;Glumin;Miglu-P;Saforis;utamine;abs9141;H-GLN-OH;L-Gln-OH
CBNumber:
CB6280105
Summenformel:
C5H10N2O3
Molgewicht:
146.14
MOL-Datei:
56-85-9.mol

Levoglutamid Eigenschaften

Schmelzpunkt:
185 °C (dec.) (lit.)
Siedepunkt:
265.74°C (rough estimate)
alpha 
32.25 º (c=10, 2 N HCl)
Dichte
1.47 g/cm3 (20℃)
Brechungsindex
6.8 ° (C=4, H2O)
FEMA 
3684 | L-GLUTAMINE
Flammpunkt:
185°C
storage temp. 
Store below +30°C.
Löslichkeit
H2O: 25 mg/mL
Aggregatzustand
solution
pka
2.17(at 25℃)
Farbe
White
PH
5.0-6.0 (25℃, 0.1M in H2O)
Optische Aktivität
[α]20/D +33.0±1°, c = 5% in 5 M HCl
Wasserlöslichkeit
Soluble in water, dimethyl sulfoxide and ethanol. Insoluble in methanol, ether, benzene, acetone, ethyl acetate and chloroform.
Decomposition 
185 ºC
maximale Wellenlänge (λmax)
λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
JECFA Number
1430
Merck 
14,4471
BRN 
1723797
Stabilität:
Stability Moisture and light sensitive. Incompatible with moisture, strong oxidizing agents.
InChIKey
ZDXPYRJPNDTMRX-VKHMYHEASA-N
CAS Datenbank
56-85-9(CAS DataBase Reference)
NIST chemische Informationen
L-Glutamine(56-85-9)
EPA chemische Informationen
L-Glutamine (56-85-9)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 36-36/37/38
S-Sätze: 26-24/25-36/37/39-27
WGK Germany  2
RTECS-Nr. MA2275100
TSCA  Yes
HS Code  29241900
Giftige Stoffe Daten 56-85-9(Hazardous Substances Data)
Toxizität LD50 orally in Rabbit: 7500 mg/kg

Levoglutamid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.

Beschreibung

Glutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders.Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500–900 μmol / l .

Chemische Eigenschaften

White, odorless crystals or crystalline powder having a slightly sweet taste. It is soluble in water and practically insoluble in alcohol and in ether. Its solutions are acid to litmus. It melts with decomposition at about 185°C.

Chemische Eigenschaften

L-glutamine is odorless, but has a slightly sweet taste L-glutamine performs a major role in DNA synthesis and sup- ports the immune system by means of glutathione synthesis.

Chemische Eigenschaften

White crystalline powder

Occurrence

Occurrences in nature
Glutamine is the most abundant naturally occurring, nonessential amino acid in the human body, and one of the few amino acids that can directly cross the blood-brain barrier.In the body, it is found circulating in the blood, as well as stored in the skeletal muscles. It becomes conditionally essential (requiring intake from food or supplements) in states of illness or injury.Dietary sources
Dietary sources of L-glutamine include beef, chicken, fish, eggs, milk, dairy products, wheat, cabbage, beets, beans, spinach, and parsley. Small amounts of free L-glutamine are also found in vegetable juices.
Aiding gastrointestinal functionGlutamine-enriched diets have been linked with maintenance of gut barrier function and cell differentiation, suggesting glutamine may help to protect the lining of the gastrointestinal tract or mucosa. People who have inflammatory bowel disease (ulcerative colitis and Crohn' s disease) may not have enough glutamine, but two clinical trials found taking glutamine supplements did not improve symptoms of Crohn' s disease.

Verwenden

L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.

Verwenden

L-Glutamine is one of the 20 amino acids encoded by the standard genetic code. Its codons are CAA and CAG. Glutamine is a substance naturally produced in the body to help regulate cell growth and function. There may also be man-made versions of these subs

Verwenden

amine protecting agent

Definition

ChEBI: An optically active form of glutamine having L-configuration.

synthetische

By isolation from sugar beet juice.

Trademarks

Nutrestore (Nutritional Restart).

Biologische Funktion

Glutamine plays a role in a variety of biochemical functions, including :
Protein synthesis, as any other of the 20 proteinogenic amino acids
Regulation of acid-base balance in the kidney by producing ammonium
Cellular energy, as a source, next to glucose
Nitrogen donation for many anabolic processes, including the synthesis of purines
Carbon donation , as a source , refilling the citric acid cycle
Nontoxic transporter of ammonia in the blood circulation.

Synthesis Reference(s)

Tetrahedron: Asymmetry, 17, p. 245, 2006 DOI: 10.1016/j.tetasy.2005.12.023
Journal of the Chemical Society, p. 3315, 1949 DOI: 10.1039/JR9490003315

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-glutamine is the most abundant amino acid in the body. It is essential for the synthesis of L-asparagine. It also helps in muscle growth through protein synthesis and increased growth hormone levels.

Biochem/physiol Actions

L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.

Sicherheitsprofil

Mddly toxic by ingestion. Human systemic effects: euphoria. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Glutamine has been used as a GI protectant and in an attempt to enhance GI healing in conditions where GI epithelium is damaged (Parvo enteritis, chemotherapy, etc.).
A study that evaluated the efficacy of glutamine supplementation in cats with methotrexate-induced enteritis found no difference between cats supplemented with glutamine and those that were not. (Marks, Cook et al. 1999)

läuterung methode

Likely impurities are glutamic acid, ammonium pyroglutamate, tyrosine, asparagine, isoglutamine, arginine. Crystallise it from water or aqueous EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1929-1925 1961, Beilstein 4 IV 3038.]

Producing and consuming organs

Producers
Glutamine is synthesized by the enzyme glutamine synthetase from glutamate and ammonia. The most relevant glutamine-producing tissue is the muscle mass, accounting for about 90% of all glutamine synthesized. Glutamine is also released, in small amounts, by the lung and the brain. Although the liver is capable of relevant glutamine synthesis, its role in glutamine metabolism is more regulatory than producing, since the liver takes up large amounts of glutamine derived from the gut.
Consumers
The most eager consumers of glutamine are the cells of intestines, the kidney cells for the acid - base balance, activated immune cells, and many cancer cells. In respect to the last point mentioned, different glutamine analogues, such as DON, Azaserine or Acivicin, are tested as anticancer drugs.
Examples for the usage of glutamine
In catabolic states of injury and illness, glutamine becomes conditionally essential (requiring intake from food or supplements). Glutamine has been studied extensively over the past 10–15 years, and has been shown to be useful in treatment of injuries, trauma, burns, and treatment - related side effects of cancer, as well as in wound healing for postoperative patients. Glutamine is also marketed as a supplement used for muscle growth in weight lifting , body building, endurance, and other sports. Evidence indicates glutamine, when orally loaded, may increase plasma HGH levels by stimulating the anterior pituitary gland. In biological research, L-glutamine is commonly added to the media in cell culture. However, the high level of glutamine in the culture media may inhibit other amino acid transport activities.

Levoglutamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Levoglutamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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56-85-9(Levoglutamid)Verwandte Suche:


  • 2,5-Diamino-5-oxpentanoicacid
  • LEVOGLUTAMIDE
  • L(+)-GLUTAMINE
  • L-GLUTAMINE
  • L(+)-GLUTAMIC ACID-5-AMIDE
  • L-GLUTAMIC ACID 5-AMIDE
  • L-GLUTAMIC ACID AMIDE
  • L-GLN
  • L-ALPHA-AMINOGLUTAMIC ACID
  • L-2-AMINOGLUTARAMIC ACID
  • 2-aminoglutaramic acid
  • 2-AMINOGLUTARIC ACID-3-MONOAMIDE
  • Miglu-P
  • Pentanoic acid, 2,5-diamino-5-oxo-, (S)-
  • Stimulina
  • H-L-GLN-OH
  • H-GLN-OH
  • GLUTAMINE
  • GLUTAMINE, L-
  • FEMA 3684
  • GLN
  • (S)-2,5-DIAMINO-5-OXOPENTANOIC ACID
  • (S)-(+)-GLUTAMINE
  • (S)-2,5-Diamino-5-oxopentanoic
  • (S)-2,5-Diamino-5-oxopentanoic acid, L-Glutamic acid 5-amide
  • (S)-2,5-Diamino-5-oxopentanoic acid, L-Glutamic acid 5-amide, L-Glutamine
  • L-Glutamine Powder
  • Concentrated Soy Protein
  • Glycine, Pyrogen-Free
  • H-Gln-OH ,≥99%
  • L-Glutamine (H-Gln-OH)
  • L-Glutamine,(S)-2,5-Diamino-5-oxopentanoic acid, L-Glutamic acid 5-amide
  • L-Glutamine, extra pure
  • Glutamine (100 mg)
  • L-GLUTAMINE, USP
  • L-GlutaMine base
  • L-GLUTAMINERESEARCH GRADE
  • MultiPharM (TM) L-GlutaMine, USP
  • L-GLUTAMINE (3,4-13C2)
  • L-GLUTAMINE (2,3,3,4,4-D5, 15N2)
  • L-Gln-OH
  • L-Glutamine, Animal-Free
  • alpha-glutamine
  • L-GLUTAMINE BIOTECHNOLOGY PERFORMANC
  • L-Glutamine≥ 99% (anhydrous assay)
  • L-Glutamine USP from non-animal source99.0-101.0% (Titration: anhydrous basis)
  • L-Glutamine, 99-100%
  • L-Glutamin
  • L-Glutamine,Liquid(200mM)
  • α-Aminoglutamic acid
  • L-Glutamine, FCC Grade L-2-Aminoglutaramic acid, FCC Grade
  • L-Glutaminee
  • L-GLUTAMINE 200 MM SOLUTION HYBRI-MAX
  • L-GLUTAMINE 98.5+% FCC
  • L-GLUTAMINE, REAGENTPLUS TM, >= 99%
  • L-GLUTAMINE BIOTECHNOLOGY PERFORMANCE &
  • L-GLUTAMINE GAMMA-IRRADIATED CELL*CULTUR E TESTED
  • GLUTAMINE (L) 200 MM
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